At work, I use a single monitor with Windows 10 to avoid a few bugs and annoyances, such as one monitor not returning when unlocking the desktop, or having to rearrange all my windows onto the multiple screens when docking the laptop, or sometimes just when returning from a break.
To compensate for the lack of screen real-estate, I start by being an individual with great eyesight. (Thank you, LASIK from 2005.) I use a high-resolution monitor and zoom everything. I have 2-3 tall-and-thin browser windows open taking ~25% of the screen width and going top-to-bottom. A tall-and-thin console or 3, a tall-and-thin Notepad++ window, and RDCMan set to take ~45% of the screen, for Windows remote desktop sessions. All manually overlapping, so they are just a click away.
At home, I use a single HDTV for my gaming HTPC. I do everything else on the kitchen laptop, an old Lenovo T400. Both also zoomed as needed.