I've gotten two remote jobs off the HN "Who's hiring?" thread. It can be a bit frustrating. I applied to every single remote posting on the thread for 2 months in a row. So I guess that's one job per month (maybe I was lucky or unlucky who knows).
Following are some of my impressions but they are subjective and perhaps a bit speculative.
Generally I've found that the attitude of most US companies is that if they are willing to hire remote, they are usually only interested in hiring candidates inside the US - even if they are a native English speaker (I was an American living in Vietnam). This is very different than the attitude that I've gotten talking to a companies in say ... Singapore or Germany.
Another thing that seems to happen is that some companies seem to throw the REMOTE OK tag to their posting without considering whether or not everyone on their engineering team is actually ok with working with a remote employee. I've done several interviews with teams that were REMOTE OK but had no existing remote employees. Usually it only takes one person to veto a hire. That's something to think about if they are looking at both local and remote candidates. Unless there is a really compelling reason to hire remote, usually they will go local (makes sense). You might not even want to work with one of these companies because they aren't set up for remote work... communication takes a bit more work from all team members - not just the remote ones.
Overall I've had a much more positive experience with the HN: "Who's hiring?"" thread than anywhere else. I think this is because the first point of contact is often an engineer and not an HR person. My resume is a bit odd and doesn't have a BRAND_NAME_SILICON_VALLEY_COMPANY or a BRAND_NAME_UNIVERSITY so it bounces right off the HR department. It's very helpful to be able to talk technology with someone in the initial conversation. If I can get a knowledgeable front-end engineer to look at some of my previous work, then I usually get to the coding round.
I had no luck with any of the remote hiring sites: remoteok.io or weworkremotely.com. YMMV
Ultimately getting a remote job seems to come down to:
1. Having some kind of portfolio to demonstrate your competence.
2. Doing as many interiews as possible. Also the more interviews you do the better you get at it.
Good luck!