Earlier quoted context omitted.
> So here's the key question: How to you best neutralize the threat of that person? Honest question: has assassination ever actually been effective at effecting the political change the assassin wants? It's probably easier now to assassinate someone than it ever has been in human history, but the actual number doesn't seem higher per capita (maybe it is, feel free to correct me on that).
1. The goal of US drone assassinations is not to effect political change but to keep the status quo. That's a different question than one you asked. 2. On a more general level, your question can be rephrased as 'has violence ever been effective at making a (political) difference'. The answer to that is - absolutely. It has actually been the most effective strategy at effecting change throughout history.
2) This is not a valid generalization and represents a leap of logic. I was talking specifically of assassinations.