I'm generally not inclined to fully whitelist anyplace because even if everything it loads
today is safe, who's to say what's going to be loaded after the site gets hacked. That said, I tried to go through and do some allowing of requests and scripts for places I recognized, including whitelisting the site in Ghostery to keep it from interfering.
After adding 19 separate exceptions in uMatrix for both whole domains and for types of requests/actions on domains, I still don't see any ads but I do see an ever-increasing list of third-party sites Wired is pulling requests from. Given a choice between throwing up my hands and saying "Fine, f*ckit, do whatever the hell you want" and whitelisting Wired's requests to all of (disqus, optimizely, amazon-adsystem, condenastdigital, demdex, typekit, adobetm, chartbeat, cloudfront, doubleclick, googleadservices, googlesyndication, googletagservices, mediavoice, mookie1, omtrdc, outbrain, parsely, scorecardresearch, yldbt and zqtk) plus whatever others would be pulled in were I actually to whitelist, I guess I'll have to do without Wired.
So far without ever actually loosening things up far enough to see ads that's AT LEAST 21 different top-level domains Wired is pulling from, not counting its own (and yes, I realize it's part of Conde Nast). Most of those top-level domains have at least 2 subdomains being pulled from, sometimes more. My basic reaction to this is that even if I trust Wired and Conde Nast, I don't know that I trust all those other sites like "mookie1," "yldbt," "zqtk" and whatever other obscurely-named domains.
Frankly, were I to see "yldbt" or "zqtk" as a running process or folder name on a system I was working on, I'd immediately rename them and start virus and malware scans.
So I guess my reading of Wired online will suffer much the same fate as my reading of Wired on paper, because while I like seeing occasional items from Wired it's not a daily destination for me, and I'm certainly not coughing up $50+/year for it.