Yup, it's true there are pathological cases.
Problems with HOL blocking can be reduced significantly with good caching though. 50 blocking requests aren't much of an issue if they're all going to return small "304 Not Modified" responses straight out of the web servers file cache.
And don't forget you can still get HOL blocking over HTTP/2... at the end of the day the browser has to start parsing HTML before it knows what else it needs to request. The only alternative is teaching your web server HTML or a set of heuristics and doing PUSH. And PUSH actually counter-acts the good in caching because when I load your index.html the web server has no idea whether I have jquery or your blogs stylesheet cached or not.
What I really want when I visit a URL is for my browser to tell the web server when I last visited, and then for the web server to give me a complete list of all dependent resources and sub-resources that have changed since that visit.... basically a set of HEAD responses that constitute a diff. My browser can then just say "hmm, ok, I needed these last time, and they've changed, so while I'm downloading index.html I'll just go ahead and request this and this and this even though I have no idea how I'm going to load them yet".
Basically, imho, all webpages should be cached as git repos ;)