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Ask HN: What startup/technology is on your 'to watch' list?

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Re: Ask HN: What startup/technology is on your 'to watch' list?

#571

Was bitcoin or blockchain mentioned on HN back when it wasn't on many radars?

It was being talked about as early as 2010: https://news.ycombinator.com/item?id=1704924 I remember a lot of discussion in 2011 on it.

I don't remember exact dates, but I can confirm this. I heard about bitcoin fairly early on from this site.

Re: Ask HN: What startup/technology is on your 'to watch' list?

#572
post #546
post #266

Earlier quoted context omitted.

Some feedback. I think I stumbled upon Zerotier a while back and didn't really get what it is. IIRC it felt like something that is only useful for big companies, exactly what I felt today. I think the website could do a better job showcasing how it's used. Hope my feedback is helpful and wish all the best!

Our web site kind of sucks. We're going to be working with a design/marketing firm to re-do it soon. It's kind of hard to explain ZeroTier sometimes. Its so simple (to the user) people have a hard time getting it. "You just make a network and connect stuff." Huh? People have been conditioned to think networking is hard because 90% of networking software is crap.

Thanks for ZeroTier! Managed to convert a few friends from using Hamachi for LAN games, which was always a pain to setup previously. It simply just works for my needs.

Re: Ask HN: What startup/technology is on your 'to watch' list?

#574
post #550

www.CloudNC.com Basically, 1) bringing down the cost of CNC machined parts down to their marginal cost through automation, 2) reducing that marginal cost through higher machine utilisation rates, and 3) reducing turn around times and accuracy of parts to clients.

ProtoLabs is already successful in this space. I wonder what competitive advantage CloudNC has?

Re: Ask HN: What startup/technology is on your 'to watch' list?

#575
post #221

Earlier quoted context omitted.

I'm kinda sad for you - I've been using and advocating zerotier for a while (it's amazing and indispensable)...but in my circles the word 'wireguard' has got people excited, which (anecdotally) is benefitting tailscale and generating more hype around them than zerotier ever got. Hopefully a rising tide will lift all ships and you find a way to capitalise on it :) (I prefer device-based zerotier-style access rather th…

We are doing fine and V2 is coming soon with a ton of improvements. I just have to occasionally point out our existence again. The pulldown showing other devices on a network does look spiffy but that wont scale. We have users with thousands of devices on a virtual LAN and the protocol will scale far larger. Not only will that not fit in a menu but any system that relies on a master list will fall down. That list and…

Really happy to hear it's all going well, and I've been excited about V2 since I read the blog post about it - your product is awesome and solves a genuine need, and I really want you to succeed.

Re: Ask HN: What startup/technology is on your 'to watch' list?

#576
post #492

Earlier quoted context omitted.

Are you referring to written notation? Calling that geometry is a bit of a stretch. There's also nothing geometric about maths encoded in computer code, or many types of mathematical thoughts, so I think you are just incorrect.

> Are you referring to written notation? Calling that geometry is a bit of a stretch. Can you write without shape? > There's also nothing geometric about maths encoded in computer code Look at a computer chip under a microscope: nothing but geometry. > or many types of mathematical thoughts In re: math itself, perhaps there is such a thing as a mathematics of the formless (I doubt it but cannot rule it out) but to co…

> and it is intrinsically a geometric act.

Why? Can't you have distinction without geometry? It's not only position which can be distinct, you can have other properties.

Two digits in different position on paper can be both different - 0 and 1 - and the same - 5 and 5. You can encode them not by shape, but, say, by kind of particle?

And in general, our physical world has space - but how would you prove a world without space as we understand it can't have math?

Re: Ask HN: What startup/technology is on your 'to watch' list?

#577
post #486

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Looks like I found that "home server" to replace my over-use of cloud resources that I've been looking for!

Well, let me recomend something else, check asrock mini-itx motherboards with on-board cpu. You can get those for ~150 euros, throw in some ram (~60 euros) and some disk (100euro) + some chasis (Phenom mini-itx for instance, ~100euros). For home server this will work great :) I am running home server (100% self hosted including emails) with J1900-itx motherboard with 20Tb of disk space (zraid) for years. No need to b…

Well, your described bundle would be over 400€ then you can purchase used PS4 at least half that price and even cheaper.

Re: Ask HN: What startup/technology is on your 'to watch' list?

#578

Earlier quoted context omitted.

Can this be used to make faster corona virus tests ? If so maybe this is the time to Manhattan project this technology.

The Oxford Nanopore people announced that they are in the 'advanced stages' of developing their own Covid-19 test called LamPORE https://twitter.com/nanopore/status/1263711292868694021 Press release: https://nanoporetech.com/about-us/news/oxford-nanopore-techn... 'Oxford Nanopore is planning to deploy LamPORE for COVID-19 in a regulated setting initially on GridION and soon after on the portable MinION Mk1C.' The Gri…

Thanks for those links! I knew it was only a matter of time

There are lots of folks working on LAMP in the DIYbio community. The kinda cool thing is that you can just have a colormetric read-out, so you don't even need Nanopore sequencing. I'm guessing that the reason Nanopore is nice there is to eliminate false positives. I'm more a fan of this approach -

https://www.genomeweb.com/business-news/clear-labs-raises-18...

Because you can recover full genomes as a by-product of diagnostic tests (which is useful for tracing infection, for example https://nextstrain.org/)

Re: Ask HN: What startup/technology is on your 'to watch' list?

#579
post #508
post #181

Earlier quoted context omitted.

Generally, yes absolutely. I’ve been doing a project called “NanoSavSeq” (Nanopore Saliva Sequencing) in my free time. It’s published on dat right now since the raw files for Nanopore are really big (got too big for hashbase). There is one company doing it as well, but my version is completely open source and I’ve optimized it for affordable automation. To give you a sense, you can buy one for 1k and do as much detec…

Is this with multiplexing? Or are you extending the flowcell life?

Multiplexing. I use barcoded primers to amplify the sample, then pool and sequence

Re: Ask HN: What startup/technology is on your 'to watch' list?

#580
post #367

Earlier quoted context omitted.

I’m a little surprised that there aren’t any mentions of Obsidian, while there are at least two mentions of Roam. To all Roam lovers, and to all intellectuals in general, I’d recommend you to check out Obsidian [1] from the makers of Dynalist. It’s also a tool made mainly for Zettelkasten Just so you know, I consider myself probably a fairly typical HN user. Got my own little daily tech concerns, but keep a toe in th…

the other thing is https://roamresearch.com/ It's a text based wiki or outliner (collapsible text) thought a step further, with auto backlinks etc. Feels to me like a weaker org-mode, online with better cross-links/embeds (something that is indeed uncool in org. things can't live in two places at once)

There is org-roam, and it's getting better by the day: https://github.com/org-roam/org-roam
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