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Ozempic shows anti-aging effects in trial

trial.medpath.com

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Re: Ozempic shows anti-aging effects in trial

#551

Post by nkmnz »

kashunstva wrote: post #519
benchly wrote: post #459

Earlier quoted context omitted.

> If Ozempic is so great, how come our bodies don't just... While I agree with your sentiment, your argument here assumes the human body always makes intelligent decisions for itself. My obstructive sleep apnea would like a word. After it's done choking me awake, of course. The body is a marvelous machine, but it is far from a perfect or intelligent design. We are lucky to have what we have, but expect operating mist…

> The body is a marvelous machine, but it is far from a perfect or intelligent design. And I think that we can only expect the process of evolution through natural selection to operate on traits that cause differential survival of individuals before reproduction. All sorts of new traits acquired through random mutation and recombination that only affect individuals after typical reproductive years will exist even whi…

Reducing the reproductive fitness of each individual after a certain life time might even increase the reproductive fitness of the species (or tribe) as a whole, because it might reduce competition between generations and foster cooperative behavior: if parents and their children compete for the same resources – from sexual partners to food needed to raise a new generation – you'd never develop the cultural norms of life long mutual support across multiple generations.

Re: Ozempic shows anti-aging effects in trial

#552

Post by beeforpork »

Just a quick check list for better understanding of the placement of the study: Is this the first study of its kind? The only one? Is it medically and scientifically sound and well-documented? Does it apply to people without (HIV-associated) lipohypertrophy? Is the effect temporary, i.e., what happens when drug use is terminated? Does it cure the lipohypertrophy or is this a life-long disease that needs medication? How are TruDiagnostic and Novo Nordisk related to each other either generally or concerning this study?

Re: Ozempic shows anti-aging effects in trial

#553

Post by satyrun »

ses1984 wrote: post #297
c4ptnjack wrote: post #216

Earlier quoted context omitted.

The zeitgeist has pushed the idea carbs/grains and sugar are terrible over the last 40 years on and off, so that seems to say more about the medical industrial complex, than anything. That's fair, but if that message has been pushed so consistently, why didn't we see a real decrease in the consumption of those things and the associated weight loss?

Because carbs taste great.

It is really more than just taste though.

I am on a GLP-1 level calorie restricted diet right now without a GLP-1 and of course it is just miserable.

I love eating a giant sandwich at night that is more calories than what I am eating all day now but it isn't the taste it is the brain chemical release.

It is an addiction like any other addiction. I have never felt that same craving for chicken breast.

Re: Ozempic shows anti-aging effects in trial

#554

Post by VeejayRampay »

strken wrote: post #358
some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

"No free lunch" is a reasonable question to ask when evaluating medication, if it would improve the evolutionary fitness of the majority of people. I think this is behind some of the skepticism. If Ozempic is so great then how come our bodies don't just produce more GLP-1? How come we aren't like chimps, with eternally shredded bodies and cheese grater abs, provided we get the protein to support them? I would guess t…

that's not why we get fat

we get fat because of the american diet, priori to which people in the world were actually not that fat

the lack of fermented food, the epidemics of ultra-processed, ultra-rich and grotesquely fat and sugary food is why people have gotten fat, which is a relatively recent phenomenon (and which is not as widespread in culture that resist the American diet the most like the French and the Japanese)

Re: Ozempic shows anti-aging effects in trial

#555

Post by wkat4242 »

strken wrote: post #358
some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

"No free lunch" is a reasonable question to ask when evaluating medication, if it would improve the evolutionary fitness of the majority of people. I think this is behind some of the skepticism. If Ozempic is so great then how come our bodies don't just produce more GLP-1? How come we aren't like chimps, with eternally shredded bodies and cheese grater abs, provided we get the protein to support them? I would guess t…

> If Ozempic is so great then how come our bodies don't just produce more GLP-1?

Because our bodies have been tuned to deal with food shortages for hundreds of thousands of years. Now we live in an age of abundance but our bodies still try to harvest each calorie they can get.

If this continues we might evolve to no longer store surplus calories as fat. Though I doubt it because the age people die from overweight related issues is way after the age most people have kids at.

But I imagine that soon we will be able to directly tune some of that evolutionary bagage that no longer applies, by gene modification.

Re: Ozempic shows anti-aging effects in trial

#556

Post by BigJ1211 »

skeezyboy wrote: post #508
WithinReason wrote: post #431

Earlier quoted context omitted.

> If Ozempic is so great then how come our bodies don't just produce more GLP-1? To store calories so you don't starve. This is a failure mode of evolution and there is in fact "free lunch" when we use technology to reoptimise our bodies to calorie abundance

> when we use technology to reoptimise our bodies to calorie abundance replace "calorie abundance" with "sedentary lifestyle" and youre there. its people eating more than they burn off because they dont exert themselves because thats what being an adult means.

Calorie abundance is accurate too, food has never been as cheap and delicious as it is now. Not to mention the ultra-processed high-density foods we have now.

Meaning you can easily overeat with an active lifestyle too. In fact we have entire sports in which it's beneficial to do so.

(Rugby/American Football, Strongman competitions and Sumo wrestling to name a few obvious ones)

Re: Ozempic shows anti-aging effects in trial

#557

Post by wkat4242 »

some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

Yeah they are often the people that don't understand overweight because it's an issue they don't have. They view it as an easy out. Which it is but the harder solution is much more difficult for some people.

It's the same with people without mental illness. They often have this "just don't be depressed" attitude.

Re: Ozempic shows anti-aging effects in trial

#558

Post by tomxor »

some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

I find it amusing that a pretty large group of people need to believe it's some kind of elixir of youth.

Did you read the abstract? It "reduces aging" in a highly selective group of people with accelerated aging from secondary effects of obesity.

> people with HIV-associated lipohypertrophy disease, a condition characterized by excess fat accumulation and accelerated cellular aging

What's next? "Ozempic shows anti-gravity effects in humans"?

Yes it makes you less hungry, no that's not a solution to the underlying issue of economically induced, nationwide shit nutrition and the enevitble overeating and health issues that ensue.. it's a dodgy crutch.

Re: Ozempic shows anti-aging effects in trial

#559

Post by jart »

jjice wrote: post #54
some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

I was kind of scared of these when Ozempic starting picking of steam for weight loss. I was worried that this would be having more negative effects. Turns out, generally speaking, if used with you doctor, these things are pretty safe, especially comparatively to some of the negatives of being overweight. And then I saw some of the stories on HN about how it's changed peoples lives for the better. And then people in m…

It's far from being a miracle. People get fat because they have a broken endocrine system that refuses to burn calories and over aggressively digests food. Ozempic solves that by making your body only desire a few mouthfuls of food each day, but does nothing to actually fix your metabolism. Other better drugs are undergoing trials which will actually do that.

Re: Ozempic shows anti-aging effects in trial

#560

Post by nkmnz »

Nesco wrote: post #437
strken wrote: post #358

Earlier quoted context omitted.

"No free lunch" is a reasonable question to ask when evaluating medication, if it would improve the evolutionary fitness of the majority of people. I think this is behind some of the skepticism. If Ozempic is so great then how come our bodies don't just produce more GLP-1? How come we aren't like chimps, with eternally shredded bodies and cheese grater abs, provided we get the protein to support them? I would guess t…

I am pretty sure uncouplers will make a come back. Just something a little more targeted and safer than good ol’ DNP

looking for this, hu? https://en.wikipedia.org/wiki/HU6
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