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I would wager greatly that it's not that he's grown cynical to people saying he can't do something, but that he's become delusional from people telling him a genius.I've been wary of defending Kanye online lately, but Kanye's influence isn't just "rap / hip hop". Kanye also broke into luxury/high-end fashion quite unexpectedly where he was given the same sort of push back. It started with him interning at Fendi (when he already was one of the largest entertainers on the planet) alongside a group of other eclectic individuals (the other most notable one, Virgil Abloh, who would go on to become creative director of Louis Vuitton).
He captured lightning twice and I can't imagine that developing into a personality into anything other than "everyone else is wrong".
That said, I don't think he's become delusional from people telling him he's a "genius", or from mental illness. Since 2020, I've seen scores of people all fall into the internet misinformation pipeline and I don't think Kanye is any different - he just has the largest platform. He's no more mentally ill than your uncle who believed COVID was a hoax. Everything he is saying is currently "mainstream" conservative ideology, his talking points are lifted directly from Candace Owens who is employed by The Daily Wire, which is run by the most famous conservative personality, Ben Shapiro, (maybe after Tucker Carlson).