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Ozempic shows anti-aging effects in trial

trial.medpath.com

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Re: Ozempic shows anti-aging effects in trial

#541

Post by lo_zamoyski »

zoeysmithe wrote: post #104
qgin wrote: post #18

Earlier quoted context omitted.

There were even people who felt this way about anesthesia too. To survive in that era, they had to believe that suffering was somehow good for healing (or at least good spiritually) and talked about anesthesia as if it were cheating the natural god-given order.

I think this might be revisionism. A lot of people feared early anesthesia because it was far more dangerous than today. I also notice people will make note that 'eccentrics' from the 1940s-1950s hated air conditioning but it helps to understand it was a dangerous technology that regularly injured and killed people back then, especially in its earlier days the adults of that period were children during. AC didn't get…

Many Europeans still have a fear of AC, drafts, cold drinks, not wearing a scarf on chilly weather, etc.

Re: Ozempic shows anti-aging effects in trial

#542

Post by lo_zamoyski »

strken wrote: post #358
some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

"No free lunch" is a reasonable question to ask when evaluating medication, if it would improve the evolutionary fitness of the majority of people. I think this is behind some of the skepticism. If Ozempic is so great then how come our bodies don't just produce more GLP-1? How come we aren't like chimps, with eternally shredded bodies and cheese grater abs, provided we get the protein to support them? I would guess t…

> cheese grater abs

Washboard abs?

Re: Ozempic shows anti-aging effects in trial

#543

Post by b112 »

cyrillite wrote: post #483
throwup238 wrote: post #364

Earlier quoted context omitted.

> How come we aren't like chimps, with eternally shredded bodies and cheese grater abs, provided we get the protein to support them? There are several reasons: Chimps have a higher density of testosterone receptors with a higher sensitivity than humans. Compared to humans, they are essentially roided out all the time. Humans are also hairless endurance hunters so we naturally have much larger fat reserves (15-25% of…

Not to mention that we really are much more similar to chimps than they’re giving us credit for. If we ate a relatively low calorie, high protein diet, and maintained an active lifestyle, we’d all be pretty damn muscular and lean. Not roided out muscular, but far more so than I think the average person expects. Our body composition is significantly determined by relatively near-zero fitness demands in modern life and…

Yes just 150+ years ago most field work was done by hand, including moving rocks from fields, plowing with an animal (and a lot of human strength too). Just clearing new roads was mostly manual work.

(Sure, you could blow up things, but then you still had to clear the bits and level the road. Yes horses existed, but mostly it was just people.)

Every activity took more physical effort, everything was maintained manually. Even if you were a bookkeeper, it was all hand written, and any math was with a slide rule or on paper, or in your head. It takes more calories to move a slide rule than work a calculator, more to write than type.

And all the while, the muscles of the arm, and the upper body are being used as you press against that paper. Moving over a page meant arm and shoulder and back and more got a bit of workout. Every little bit added up.

Now we often type without moving our upper arms or shoulders. Without a change in back or upper torso movement.

It takes more calories to read than just sit still, more calories to think deeply than not.

Even going to the bathroom meant putting on boots and coat, and walking to the outhouse.

We're immensely lazy today as a peoples.

Re: Ozempic shows anti-aging effects in trial

#544

Post by everfrustrated »

ykonstant wrote: post #411
toomuchtodo wrote: post #326

Earlier quoted context omitted.

Get a GLP-1 under the supervision of a doctor or other licensed medial provider.

As a chronically obese, non-diabetic individual, here in Greece it is impossible to convince a doctor to prescribe anything close to that :(

I find this hard to believe. Wegovy is authorised for sale in the EU for weight loss (IE not Ozempic which is for diabetes. Yes I know it's the same drug). If you can't find someone to prescribe it, that's on you. Find a better doctor or pharmacist. In all seriousness, please do - obesity is no joke and taking ownership of this by at the very least finding a doctor who will support you might be one of the most important and life changing decisions you make.

Re: Ozempic shows anti-aging effects in trial

#545

Post by ben_w »

sjw987 wrote: post #511
dan-robertson wrote: post #505

Earlier quoted context omitted.

Is it possible to avoid having the same discussion every time anything related to Ozempic comes up?

It's an important discussion. We should all be aiming to do better. Instead we're just lowering the standards for everything. Only the morbidly obese should be using these drugs to get down to a healthy enough (overweight) level to lose the rest with sensible discipline, healthy/less eating (mostly this), and exercise (less this, but important for the mind, strength and cardio). Discipline and basic understanding of…

> If people can't be arsed doing that and we give easy shortcuts for everything in life, what's the point in being alive?

Embrace the shortcuts. Life's too short not to.

What's that Plato quote about writing?

  If men learn this, it will implant forgetfulness in their souls. They will cease to exercise memory because they rely on that which is written, calling things to remembrance no longer from within themselves, but by means of external marks.

  What you have discovered is a recipe not for memory, but for reminder. And it is no true wisdom that you offer your disciples, but only the semblance of wisdom, for by telling them of many things without teaching them you will make them seem to know much while for the most part they know nothing.
And yet, here were are, conversing at all only because of writing.

Re: Ozempic shows anti-aging effects in trial

#546

Post by b112 »

glp1guide wrote: post #506
gavinray wrote: post #491

Earlier quoted context omitted.

I've used Retatrutide and wasn't that impressed I used 5mg/wk (Have used Semaglutide, Tirzepatide, and Retatrutide. For Sema/Tirz, I've had both RX and grey market.)

Interesting -- would love to hear anything more you have to share! The research numbers would suggest that Reta was top, results wise. Any other significant differences you felt/noticed? Also, do you find Tirz to be an imiprovement over Sema?

The problem with online is, were all those Reddit posts you saw just astroturfers? And the whole point, to drum up funding for Reta? Or buzz?

One person can easily turf as 1000 too, posting from a few accounts every day over the course of a year.

Re: Ozempic shows anti-aging effects in trial

#547

Post by jart »

strken wrote: post #358
some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

"No free lunch" is a reasonable question to ask when evaluating medication, if it would improve the evolutionary fitness of the majority of people. I think this is behind some of the skepticism. If Ozempic is so great then how come our bodies don't just produce more GLP-1? How come we aren't like chimps, with eternally shredded bodies and cheese grater abs, provided we get the protein to support them? I would guess t…

It only makes sense if you understand that everyone is being poisoned, and this is the cure.

Re: Ozempic shows anti-aging effects in trial

#548

Post by ACCount36 »

y-curious wrote: post #56
some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

I am one of those people to some extent. For me, it's the naturalistic fallacy I can't get over. I drink caffeine daily, but the idea of hijacking my hunger with an injectable induces dread. I would like to believe that there are no long-term side effects, but: 1. We have to trust the data of for-profit pharmaceutical companies and their trials. They are incentivized to produce optimistic results. 2. It's relatively…

I'd trust for-profit pharmaceutical companies before I would trust "all chemicals are evil and bad" Facebook moms.

Re: Ozempic shows anti-aging effects in trial

#549

Post by b112 »

freehorse wrote: post #428
mbac32768 wrote: post #306

Earlier quoted context omitted.

The skepticism people have towards metabolic dysregulation models of obesity is too much. We know for a fact the inverse happens: girl starves herself for years to slim down to become a ballerina, eventually decides it's not worth it and tries to stop being so dangerously thin and... can't. She never feels hungry. Every time she eats she can only stomach a few bites before pushing it away. Just eat ice cream? Instant…

This concept would be hard to grasp for me if I did not know personally a person facing such issue. I don't think most people can understand that "just eat more" does not work in such cases, because most people can eat just fine even if not really hungry.

Just look at people with cancer. Many simply cannot eat. At all. They just cannot do it. It's not depression, loads of other diseases and conditions are depressing, yet people can still eat.

And while the person is clearly sick, every loved one tries to help by hoping to find food they can eat. Yet it just doesn't work. I've personally seen feeding tubes put in, to help in this regard.

There's some mechanism involved, and I've often wondered if the body knows food will also feed the tumor and is attempting to starve it. Regardless, the 'switch' is there.

Re: Ozempic shows anti-aging effects in trial

#550

Post by sjw987 »

ben_w wrote: post #545
sjw987 wrote: post #511

Earlier quoted context omitted.

It's an important discussion. We should all be aiming to do better. Instead we're just lowering the standards for everything. Only the morbidly obese should be using these drugs to get down to a healthy enough (overweight) level to lose the rest with sensible discipline, healthy/less eating (mostly this), and exercise (less this, but important for the mind, strength and cardio). Discipline and basic understanding of…

> If people can't be arsed doing that and we give easy shortcuts for everything in life, what's the point in being alive? Embrace the shortcuts. Life's too short not to. What's that Plato quote about writing? If men learn this, it will implant forgetfulness in their souls. They will cease to exercise memory because they rely on that which is written, calling things to remembrance no longer from within themselves, but…

There's a time and place for shortcuts. Health and fitness shortcuts hold more to lose than they do to gain.

Sometimes the long way is better long term. A healthy attitude towards eating and fitness can, and usually does, elevate your life experience many times over. Taking a shortcut in these erases any personal development and learning experience you could get from finding a sport you love, changing your views on food.

A diatribe about Plato doesn't make the universal argument for taking shortcuts. Do you want the people building your home and infrastructure making shortcuts? Do you want doctors in training to shortcut their studies? Why work out and train longer when you can just take anabolic steroids? Why read (or watch films) if you can just skim the summaries on Wikipedia?

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