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GLP-1 drugs: An economic disruptor? (2024)

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Re: GLP-1 drugs: An economic disruptor? (2024)

#541

Post by codr7 »

dghlsakjg wrote: post #137
codr7 wrote: post #22

Earlier quoted context omitted.

I realize obesity a major issue for a lot of people. But is it worth giving up your impulses? I mean all of them. I have no proof that's how it works long term, but I do feel the question should be asked before we dive in head first.

Anecdotally, it isn’t really giving up impulses. It blunts the desire for a lot of the ones that are related to consumption. I can still get a wild idea at 9 pm and lose myself in code. I still see flowers and buy them form my wife without planning. I still have a bowl of ice cream before bed sometimes. The best way to describe it is that you still have the impulse, but you are able to rationally consider it.

But how does the drug differentiate between consumption and other impulses?

If that's where your most powerful impulses are, that's where you're going to notice the difference.

Re: GLP-1 drugs: An economic disruptor? (2024)

#542

Post by aenis »

maxerickson wrote: post #531
aenis wrote: post #475

Earlier quoted context omitted.

No, I eat a lot less in general and a whole lot of veggies. I followed the same routine 4 years ago, then I stopped and when I started eating carbs my vo2max recovered overnight . I think one cant have it all - either you run on stored energy which caps the power to weight ratio - or on readily available glucose and glycogen. Its fine, I am not an athlete, I do sports to feel good. I dont see an impact on raw strengt…

Do you mean aerobic performance in the last sentence?

Anaerobic - i feel more or less normal while under aerobic load, and i can sustain significantly less anaerobic load - i used to be able to maintain 1600W for about 30 seconds (equivalent to a sprint to a finish line at pro-cyclist level). I can barely touch 1000W while on fast/low carb diet. I did a few experiments, and after carb loading I get an immediate increase in anaerobic perf.

Re: GLP-1 drugs: An economic disruptor? (2024)

#543

Post by toomuchtodo »

akutlay wrote: post #508
toomuchtodo wrote: post #368

Earlier quoted context omitted.

https://data.worldobesity.org/rankings/ https://www.who.int/activities/controlling-the-global-obesit... The US isn’t even the top 9. Obesity is a global epidemic of Western disease. The food isn’t the cause, it’s the symptom of the brain chemistry. If it isn’t available, yes, the disease may not present. But if available, due to hormones causing the drive , it presents. Like cigarettes (nicotine), like cocaine, like…

All the countries above US have less than 1M population and generally poor countries. Saying that obesity is not related to the underlying social problems in the US showing this data is ridiculous.

https://www.bloomberg.com/news/articles/2025-03-03/china-ind... | https://archive.today/UeI7X

https://www.thelancet.com/journals/lancet/article/PIIS0140-6...

> Rates of overweight and obesity increased at the global and regional levels, and in all nations, between 1990 and 2021. In 2021, an estimated 1·00 billion (95% uncertainty interval [UI] 0·989–1·01) adult males and 1·11 billion (1·10–1·12) adult females had overweight and obesity. China had the largest population of adults with overweight and obesity (402 million [397–407] individuals), followed by India (180 million [167–194]) and the USA (172 million [169–174]). The highest age-standardised prevalence of overweight and obesity was observed in countries in Oceania and north Africa and the Middle East, with many of these countries reporting prevalence of more than 80% in adults. Compared with 1990, the global prevalence of obesity had increased by 155·1% (149·8–160·3) in males and 104·9% (95% UI 100·9–108·8) in females. The most rapid rise in obesity prevalence was observed in the north Africa and the Middle East super-region, where age-standardised prevalence rates in males more than tripled and in females more than doubled. Assuming the continuation of historical trends, by 2050, we forecast that the total number of adults living with overweight and obesity will reach 3·80 billion (95% UI 3·39–4·04), over half of the likely global adult population at that time. While China, India, and the USA will continue to constitute a large proportion of the global population with overweight and obesity, the number in the sub-Saharan Africa super-region is forecasted to increase by 254·8% (234·4–269·5). In Nigeria specifically, the number of adults with overweight and obesity is forecasted to rise to 141 million (121–162) by 2050, making it the country with the fourth-largest population with overweight and obesity.

Re: GLP-1 drugs: An economic disruptor? (2024)

#544

Post by sfpotter »

lurk2 wrote: post #259
sfpotter wrote: post #156

Earlier quoted context omitted.

??? They're going to be trying to get on a weight loss drug, not an "impulse control drug". And I don't see why you would assume there's little overlap between people who desperately want to lose weight and people who drive drunk.

From the article: "We're not just talking about weight loss. We're discussing the first medication that effectively regulates human impulse control. Think about that." > I don't see why you would assume there's little overlap between people who desperately want to lose weight and people who drive drunk. This is only a hunch, but I would guess that drunk driving is associated with low conscientiousness and that the so…

The way ozempic is currently marketed is as a weight loss drug. People can be overweight for many reasons. Impulse control might be one of them.

Drunk driving is associated with low impulse control due to being drunk. Being drunk might be associated with the kind of lack of impulse control that ozempic targets.

Re: GLP-1 drugs: An economic disruptor? (2024)

#545

Post by walleeee »

crazygringo wrote: post #373
walleeee wrote: post #282

Earlier quoted context omitted.

Does grandma have a profit motive? Does grandma care about your wellbeing? Is grandma a vast conglomerate of strangers who couldn't give two flying fucks about you on a good day? Is plain old sugar, animal fat, and salt unhealthy in large quantities? Of course, but eating grandma's mashed potatoes and cherry pie once a week will not materially affect your health. Meanwhile you pass 8 taco bells on your way home from…

Right. But that's my whole point, you're agreeing with me. It's not the food itself. The food isn't being "manipulated" in some sinister, unnatural way. It's not about supposedly addictive "dopamine pathways". It's other things, whether convenience or advertising or whatever.

No, I don't think I am.

> > Big food corporations profit from ultra-processed foods that manipulate our natural systems.

> I've just never bought this

Yours is a rather strange reading if you truly mean to absolve the food of sinister intent. Clearly it has none.

Nor must the corporate entity producing it. That's the nature of moloch. You get bad outcomes even without outright villainy on anyone's part.

The food is being "manipulated" in the same way Grandma manipulates it, sure. Grandma bakes a pie from whole ingredients, sourced perhaps from an area farm or maybe even her backyard, with her bare hands. Show me how a Twinkie is made. The naturalistic fallacy is irrelevant.

It is simply wrong, not to mention naive, to think companies do not optimize their products to maximize impulse/repeat consumption. They are most certainly aware of dopamine pathways. This is one, and indeed a big one, of those

> other things

you mention. Convenience and advertising are big ones too. Why do we need so much convenience, and see so much advertising? Perhaps it has to do with the ordering of our lives around the very sort of institutions that sell us ultra-processed foods.

Re: GLP-1 drugs: An economic disruptor? (2024)

#546

Post by HDThoreaun »

otterley wrote: post #266
crazygringo wrote: post #260

Earlier quoted context omitted.

Oh, I'm familiar with it. And you know what? They mostly are doing what grandma does. Just in vastly larger ovens etc. Even if you want to talk about corn syrup, what do you think grandma made her pecan pie with? And the things that are different -- emulsifiers, stabilizers, natural/artifical flavors, etc. -- aren't actually making the product unhealthy, at least not in any way that causes weight gain. Those aren't s…

I don’t know if it’s the nature of the products themselves, or if it’s because they’re vastly cheaper and more accessible. There’s a natural limit to the number of cookies to be had from Grandma before she says “that’s enough,” vs being able to get 64 at the local market anytime you want for a pittance.

Really just feels to me like youre blaming the wrong entity here. Why is it too much to expect adults to act like adults and make decisions for themselves? If the companies were selling directly to kids sure but why is it their fault that people cant control themselves?

Re: GLP-1 drugs: An economic disruptor? (2024)

#547

Post by HDThoreaun »

walleeee wrote: post #545
crazygringo wrote: post #373

Earlier quoted context omitted.

Right. But that's my whole point, you're agreeing with me. It's not the food itself. The food isn't being "manipulated" in some sinister, unnatural way. It's not about supposedly addictive "dopamine pathways". It's other things, whether convenience or advertising or whatever.

No, I don't think I am. > > Big food corporations profit from ultra-processed foods that manipulate our natural systems. > I've just never bought this Yours is a rather strange reading if you truly mean to absolve the food of sinister intent. Clearly it has none. Nor must the corporate entity producing it. That's the nature of moloch. You get bad outcomes even without outright villainy on anyone's part. The food is b…

Food companies maximizing the utility we get from eating their food is a good thing actaully. Im very grateful for all the delicious food on the market. Not the companies fault that some people never learned to consume in moderation.

Re: GLP-1 drugs: An economic disruptor? (2024)

#548

Post by WaxProlix »

esseph wrote: post #485
WaxProlix wrote: post #414

Earlier quoted context omitted.

What side effects/problems are you referring to?

Non-stop nausea and uncontrollable vomiting every day since. She's been to numerous doctors and even got her stomach scoped. https://time.com/7130456/ozempic-side-effects-wegovy-mounjar...

That sounds awful :( sorry yall are going through that.

Re: GLP-1 drugs: An economic disruptor? (2024)

#549

Post by otterley »

HDThoreaun wrote: post #546
otterley wrote: post #266

Earlier quoted context omitted.

I don’t know if it’s the nature of the products themselves, or if it’s because they’re vastly cheaper and more accessible. There’s a natural limit to the number of cookies to be had from Grandma before she says “that’s enough,” vs being able to get 64 at the local market anytime you want for a pittance.

Really just feels to me like youre blaming the wrong entity here. Why is it too much to expect adults to act like adults and make decisions for themselves? If the companies were selling directly to kids sure but why is it their fault that people cant control themselves?

> Why is it too much to expect adults to act like adults and make decisions for themselves?

Because people don't act rationally. The model of a human as a rational actor who deeply considers all of the potential impacts of their decisions is a fiction that has been proven flawed by countless studies. Those actions can have externalities and consequences for which the public bears the cost, not just the actor.

> why is it their fault that people cant control themselves

Nobody's ascribing fault here; rather, we're trying to understand the bigger picture.

Re: GLP-1 drugs: An economic disruptor? (2024)

#550

Post by HDThoreaun »

otterley wrote: post #549
HDThoreaun wrote: post #546

Earlier quoted context omitted.

Really just feels to me like youre blaming the wrong entity here. Why is it too much to expect adults to act like adults and make decisions for themselves? If the companies were selling directly to kids sure but why is it their fault that people cant control themselves?

> Why is it too much to expect adults to act like adults and make decisions for themselves? Because people don't act rationally. The model of a human as a rational actor who deeply considers all of the potential impacts of their decisions is a fiction that has been proven flawed by countless studies. Those actions can have externalities and consequences for which the public bears the cost, not just the actor. > why i…

> Those actions can have externalities

I dont believe that people who eat unhealthy food have any doubts about the effect of the food. They just dont care that its unhealthy, that isnt an externality.

> Nobody's ascribing fault here; rather, we're trying to understand the bigger picture.

The bigger picture is that more products that people enjoy is a good thing, and if some people cant handle that its not societys fault.

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