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How long til we're all on Ozempic?

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Re: How long til we're all on Ozempic?

#541

Post by rootusrootus »

vundercind wrote: post #265
dfxm12 wrote: post #170

Instead of a system that makes these drug available for purchase, I'd rather live in a system that promotes healthy food and active behavior. Unfortunately, I have to drive everywhere, work too many hours to have free time for recreation and have no idea which government subsidy is going to help big ag likely at the expense of my health. All things being equal, I'd prefer to spend less money on prescriptions and have…

It’s been studied pretty well. Possible effective solutions to the US obesity epidemic are pretty much limited to: 1) Radically alter aspects of food culture, work culture, social policy, and business regulation. 2) Magic pill (/injection) There appears to be no imminent progress on the many parts of #1 that need serious work, so if we want a big turn-around in the next half-century, #2 has suddenly and surprisingly…

> Possible effective solutions to the US obesity epidemic

Just wanted to mention that this is not a US problem, and framing it as such won't help find solutions. Even in southeast Asia the rates over obesity are steadily increasing. Europe is already much fatter than southeast Asia. This is a worldwide phenomenon.

Re: How long til we're all on Ozempic?

#542

Post by asadhaider »

colordrops wrote: post #518
robohydrate wrote: post #299

I've been on tirzepatide (Mounjaro) for 4 months now. I'm down 13% of my body weight. I realized that frequent cannabis consumption interferes with the weight loss, so I've kicked the habit from daily to occasionally on weekends. I've started walking 2-3 miles a day, 2-3 days a week regularly, in addition to eating less and being more motivated to calorie count. All this to say, this drug has been life changing for m…

Did you notice that cannabis consumption interferes with weight loss due to interfering with motivation to stick to your health goals? Or did it interfere with your metabolism in some way?

I can answer this, I've been on Ozempic in the past and prescribed Mounjaro (Tirzepatide) currently (month 3).

I've had a medical cannabis prescription for many years and vaporise up to 3g a day which is quite a bit. It definitely interferes with my cravings for food, as you know the common 'munchies' effect, making me eat when I'm not really hungry or binge snacks.

I gave up on Semaglutide (Ozempic) after a few months, but Tirzepatide is working a lot more effectively and has been better.

Cannabis also helps a lot with the nausea side effect for me which can be particularly bad the first few days going up a dosage every month. It takes six months to titrate from the starter dose to full strength, if necessary.

Also the downside a lot of people don't talk about is that most people need to be on these drugs for life. They also aren't cheap.

Re: How long til we're all on Ozempic?

#543

Post by spondylosaurus »

apwell23 wrote: post #429
robohydrate wrote: post #299

I've been on tirzepatide (Mounjaro) for 4 months now. I'm down 13% of my body weight. I realized that frequent cannabis consumption interferes with the weight loss, so I've kicked the habit from daily to occasionally on weekends. I've started walking 2-3 miles a day, 2-3 days a week regularly, in addition to eating less and being more motivated to calorie count. All this to say, this drug has been life changing for m…

Have you noticed any effect on gastric emptying. As someone with 'tummy issues' ( ibs/gerd ect) i am apprehensive of messing with my digestive systems.

If your IBS is the "stuff moves too fast" variety (so, IBS-D) GLP-1s seem to help a lot since they slow things down. If your problems already stem from things moving too slow... maybe not so much :P

Re: How long til we're all on Ozempic?

#544

Post by mrshadowgoose »

OptionOfT wrote: post #420

As someone who struggled with their weight his whole life, this medication is a god send. My wife and I cook every evening. We never eat food made in a factory. We buy raw products and spend a good amount of time every day cooking them. Every morning I wake up and go on a 5 mile hike. And still weight kept on coming on. Worse yet, I am on ADHD medication, which are amphetamines and actually make you lose weight. Yet.…

> Why do we find it acceptable to help people who struggle with alcohol abuse, or nicotine addiction, or opioid addiction, but not to help people who struggle with food abuse?

"Getting fit and staying fit" is a form of social capital, because it's extremely hard and only within reach of a small portion of the population. "Being fit" is strongly aligned with "being attractive" which confers all sorts of cross-cutting social benefits.

Some people feel cheated when medication allows others to "effortlessly" join this social club, and then become vile and hateful in response.

Re: How long til we're all on Ozempic?

#545

Post by knowitnone »

itronitron wrote: post #450
dfxm12 wrote: post #170

Instead of a system that makes these drug available for purchase, I'd rather live in a system that promotes healthy food and active behavior. Unfortunately, I have to drive everywhere, work too many hours to have free time for recreation and have no idea which government subsidy is going to help big ag likely at the expense of my health. All things being equal, I'd prefer to spend less money on prescriptions and have…

It would be interesting to run an experiment where everyone in first world countries was able to (and had to) walk to the grocery store to buy their groceries. It seems like that would promote useful exercise while self regulating consumption.

I walk to the grocery store all the time. This was part of my weight loss strategy and I chose to walk to a farther grocery store. And yes, I did attain my weight loss goals.

Re: How long til we're all on Ozempic?

#546

Post by swat535 »

Uehreka wrote: post #271
farceSpherule wrote: post #237

A lot of people fail to realize that eating healthy and exercising is not enough for a lot of people who fight with their weight their entire lives. Ozempic and Wegovy are game changes and have real, tangible health benefits. One person told me, "No matter how much I eat or exercise, I have been 'hungry' my entire life. That ended when I started taking these drugs."

I gained about 50 pounds the past decade and the past year I’ve been trying to lose it. I weighed myself at the beginning: 205 lbs I started running 30 minutes per day (heartrate training targeting about 140-150), every day, for 10 months. I kept my diet the same as before (though with a protein bar after the run). Weighed myself every week or two, always within a couple pounds of 205. In March I ramped up my runs to…

Exercising won't work, weight loss happens in the kitchen.. You can do some moderate exercise of course but you should count calories and eat less (don't forget to recalculate your requirements as you lose weight!).

Re: How long til we're all on Ozempic?

#547

Post by bobro »

Uehreka wrote: post #271
farceSpherule wrote: post #237

A lot of people fail to realize that eating healthy and exercising is not enough for a lot of people who fight with their weight their entire lives. Ozempic and Wegovy are game changes and have real, tangible health benefits. One person told me, "No matter how much I eat or exercise, I have been 'hungry' my entire life. That ended when I started taking these drugs."

I gained about 50 pounds the past decade and the past year I’ve been trying to lose it. I weighed myself at the beginning: 205 lbs I started running 30 minutes per day (heartrate training targeting about 140-150), every day, for 10 months. I kept my diet the same as before (though with a protein bar after the run). Weighed myself every week or two, always within a couple pounds of 205. In March I ramped up my runs to…

Running for 30 minutes is maybe 200-400 calories. If you trigger your body to eat more because of that or you are more lazy throughout the day because you’re tired after running, it’s a wash. Exercise is not the route to weight loss. It’s like 80-90% diet.

Re: How long til we're all on Ozempic?

#548

Post by spondylosaurus »

apsec112 wrote: post #8

This compares Ozempic with past drugs, but sales of past drugs are almost always limited by demand. I'm not sure there's much to learn here for a drug that is limited by supply. Also, this part is silly: "The announced investments across both companies total $32 billion. GLP-1s were 71% of Novo’s revenue in 2023, 16% of Lilly’s in 2023, and 26% of Lilly’s in 2024Q1. If these sales are proportional to the manufacturin…

I'm shocked that TFA doesn't mention the (massive, booming) market for compounded semaglutide and tirzepatide. The long-term future is uncertain, but since these drugs have been under shortage status, third-party pharmacies can legally compound them to meet increased demand.

Re: How long til we're all on Ozempic?

#549

Post by rootusrootus »

paulmist wrote: post #249
dfxm12 wrote: post #170

Instead of a system that makes these drug available for purchase, I'd rather live in a system that promotes healthy food and active behavior. Unfortunately, I have to drive everywhere, work too many hours to have free time for recreation and have no idea which government subsidy is going to help big ag likely at the expense of my health. All things being equal, I'd prefer to spend less money on prescriptions and have…

What is a realistic path to this? Being from Europe I visited US last year and was horrified at the quality of your food. You see a lot of documentaries/youtube videos/etc... discussing the problem, but how do you even go about this?

> Being from Europe

Why is the quality of food in Europe so much worse than southeast Asia?

Because you guys are way, way, way fatter than e.g. the Japanese.

Back on topic -- we have excellent food in the US, but regulations allow for highly processed crap to be sold too. Pretty sure most of the crappy processed foods are easily available in Europe, too.

Re: How long til we're all on Ozempic?

#550

Post by cyberax »

ploppyploppy wrote: post #466
cyberax wrote: post #222

Earlier quoted context omitted.

> One thing that it seems we are just starting to talk about with these drugs is the associated muscle and bone density loss. Muscle loss is associated with _any_ kind of weight loss. And GLP-1 drugs _improve_ the bone density: https://academic.oup.com/jcem/article/100/8/2909/2836097 It's likely simply because thinner people naturally move more.

Can these negative effects be countered/offset by continuing weight training? I lift 2-4 days a week.

Certainly, just like with any other diet.

I gained muscle mass by doing strength training 2 times a week while on GLP-1 drugs.

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