Lots of comments already, but I'll chime on in. I realized this very late in life, but I have a test for when it's time to pay attention to a new technology. It's when technical people look at what seems like a groundbreaking idea, seem unimpressed, and say "couldn't you just _____", were the blank is filled with something a nontechnical person doesn't understand or considers very cumbersome. The web: couldn't you ju…
I didn't pay attention to early Twitter, but I'd wager it probably leaned pretty heavily to the software dev demographic.
There is a bit of a disconnect that a lot of people are casting technical users as if it's the group that you shouldn't listen to. As if you can find single cases and say "See!" and that proves the point [1]. Yet an overwhelming percentage of products in the technology space first saw success among the most technical of all. If you don't get that group, it often is doomed to failure.
[1] - just as an aside, there is a tendency of many to point out some "top" comment on some site like HN as if it therefore is the majority opinion. It doesn't work that way. We all don't have mandatory votes on every comment, and even a tiny amount of clustering can send a minority opinion to the top.