Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Ozempic shows anti-aging effects in trial

trial.medpath.com

Post reply on HN
Print view View original

531–540 of 868 posts

Re: Ozempic shows anti-aging effects in trial

#531

Post by skeezyboy »

komali2 wrote: post #514
skeezyboy wrote: post #510

Earlier quoted context omitted.

go out and get some exercise, run around, why is this never an option?

Because it isn't, so oh well. I'm continually frustrated with the four thousand year old history of people being surprised that other people "don't just ${something good for you} and don't just stop ${something bad for you}." Great, we've tried the "Acting surprised people do unhealthy or bad things" strategy and the "scolding people for doing unhealthy things" strategy for a couple millennia and people still do the…

youre distant ancestors chased every meal they ate. your more recent centuries old ancestors probably worked 6.5 day weeks, 12 hour shifts, and had to have all the children working as well, for a pittance. YOU on the other hand have no problem finding any kind of out-of-season food and probably drive everywhere, barely lifting a finger in comparison. THIS IS THE DIFFERENCE.

Why were there no obese (poor) people 100 years ago?

Re: Ozempic shows anti-aging effects in trial

#532

Post by AngryData »

strken wrote: post #358
some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

"No free lunch" is a reasonable question to ask when evaluating medication, if it would improve the evolutionary fitness of the majority of people. I think this is behind some of the skepticism. If Ozempic is so great then how come our bodies don't just produce more GLP-1? How come we aren't like chimps, with eternally shredded bodies and cheese grater abs, provided we get the protein to support them? I would guess t…

I agree with you overall, but humans atrophying muscle away so rapidly, and also building muscle so quickly, is fairly unique to humans so im not sure there has to be a downside to being shredded all the time like a gorilla through some sort of medical treatment in the future. We certainly haven't figured that out now, but I wouldn't be surprised if some gene therapy and chemical cocktail couldn't allow it safely someday. From everything ive seen it seems to be just a calorie saving adaptation so more energy can go to the brain. And perhaps make more varied and specialized living strategies, made possible thanks to our brain, more efficient by not supporting large muscle groups we don't always need.

Of course maybe its not possible, but it is the default for pretty much every other animal so its not like it is trying something completely outrageous like trying to eliminate sleep.

Re: Ozempic shows anti-aging effects in trial

#534

Post by niklasbuschmann »

ap99 wrote: post #503

This, like much of the pharmaceutical approach to well-being, is treating symptoms and not the problem. Metabolic dysfunction? Fix the metabolism. Poor understanding of nutrition? Fix the understanding. Lack of emotional or self-control? Fix the discipline. Obesity is largely NOT an acute symptom and does not need an acute solution. If you don't fix the underlying problem you will have weight issues your whole life (…

You really believe that skinny people are just more disciplined than obese? I would highly doubt that most skinny people actively try to keep their weight down, it‘s just how they are.

Re: Ozempic shows anti-aging effects in trial

#535

Post by komali2 »

op00to wrote: post #204
throwawaylaptop wrote: post #193

Earlier quoted context omitted.

[flagged]

You’re a fool. “Pull out” does not protect against pregnancy or STDs. Pre-ejaculate can have viable sperm in it.

Pull out method is a less viable method of preventing pregnancy, and especially less viable at preventing STDs. However, it's still considered a contraceptive strategy.

https://www.plannedparenthood.org/learn/birth-control/withdr...

For every 100 people who use pull out method perfectly, within a year, 4 will get pregnant. Since not everyone does a great job doing it, in reality 22 get pregnant every year.

Here's a great overview page: https://www.plannedparenthood.org/learn/birth-control in summary, condoms are 87% effective at preventing pregnancy, and withdrawal is 78% effective.

For a going-steady couple that isn't worried about STDs, keeps an emergency contraceptive ('morning after pill') ready for oopsie mistakes, and live in a country that grants women bodily autonomy (or have discussed and accepted that a mistake might lead to a child), pullout is a perfectly valid contraceptive mechanism. There are better, but considering that basically every method except a condom/internal condom can cause extreme discomfort or bad side effects to the woman in the relationship, I think it's totally fine to choose pull-out.

Re: Ozempic shows anti-aging effects in trial

#536

Post by lo_zamoyski »

guerrilla wrote: post #527
sjw987 wrote: post #511

Earlier quoted context omitted.

It's an important discussion. We should all be aiming to do better. Instead we're just lowering the standards for everything. Only the morbidly obese should be using these drugs to get down to a healthy enough (overweight) level to lose the rest with sensible discipline, healthy/less eating (mostly this), and exercise (less this, but important for the mind, strength and cardio). Discipline and basic understanding of…

Nah man. I'm overweight and despite trying everything I possibly can for most of my adult life, I still can't win. I do everything you're supposed to do but it's just not possible to maintain long-term. It's a constant struggle. You don't have discipline. It's just easier for you. That's all. I still won't use this drug but don't try to tell me I failed because of a lack of effort, understanding, exercise, "disciplin…

What is the source of difficulty in your case? Are you comparing your situation to that of someone with a predisposition for alcoholism?

Re: Ozempic shows anti-aging effects in trial

#537

Post by sjw987 »

guerrilla wrote: post #527
sjw987 wrote: post #511

Earlier quoted context omitted.

It's an important discussion. We should all be aiming to do better. Instead we're just lowering the standards for everything. Only the morbidly obese should be using these drugs to get down to a healthy enough (overweight) level to lose the rest with sensible discipline, healthy/less eating (mostly this), and exercise (less this, but important for the mind, strength and cardio). Discipline and basic understanding of…

Nah man. I'm overweight and despite trying everything I possibly can for most of my adult life, I still can't win. I do everything you're supposed to do but it's just not possible to maintain long-term. It's a constant struggle. You don't have discipline. It's just easier for you. That's all. I still won't use this drug but don't try to tell me I failed because of a lack of effort, understanding, exercise, "disciplin…

You just haven't got there yet. You haven't failed.

It really just comes down to eating less and healthier. Some people have metabolic differences either side, but they don't amount to a great deal.

Weight loss drugs suppressing your appetite literally shows this to be true. You just need to do it yourself without the drug. Eventually you'd want to come off the drug, right? When that happens, you would need to do just this.

Every time I've heard somebody say they've tried everything, they usually haven't. It's not a failing, it's an opportunity to keep trying and get it right.

Re: Ozempic shows anti-aging effects in trial

#538

Post by xienze »

guerrilla wrote: post #527
sjw987 wrote: post #511

Earlier quoted context omitted.

It's an important discussion. We should all be aiming to do better. Instead we're just lowering the standards for everything. Only the morbidly obese should be using these drugs to get down to a healthy enough (overweight) level to lose the rest with sensible discipline, healthy/less eating (mostly this), and exercise (less this, but important for the mind, strength and cardio). Discipline and basic understanding of…

Nah man. I'm overweight and despite trying everything I possibly can for most of my adult life, I still can't win. I do everything you're supposed to do but it's just not possible to maintain long-term. It's a constant struggle. You don't have discipline. It's just easier for you. That's all. I still won't use this drug but don't try to tell me I failed because of a lack of effort, understanding, exercise, "disciplin…

> don't try to tell me I failed because of a lack of effort, understanding, exercise, "discipline", etc.

Not to be _too_ rude here, but clearly you missed the mark on at least one of those things. If you're burning more energy than you're consuming, it's impossible to not lose weight. Maybe you underestimated how many calories you were consuming, overestimated how many calories you were burning, didn't do it often enough, didn't do it for a long enough period of time, had a few too many "cheat days", or some combination thereof.

Re: Ozempic shows anti-aging effects in trial

#539

Post by komali2 »

throwawaylaptop wrote: post #183
tuesdaynight wrote: post #174

Earlier quoted context omitted.

Just scale that solution to millions of people and the comparison will be relevant.

If you told millions of people that bread, sugar, pasta and bread are basically killing them, and to flat out stop eating them.. you probably would help people lose weight (and save many lives too). My dad has finally understood that grains are for people that need help maintain weight or gaining weight. No fat person should ever be eating them.

23% of PRC citizens are overweight or obese, compared to 73% of Americans. In the PRC, rice is typically had with every lunch and dinner, and sometimes breakfast as well. Plain old white rice, the worst kind from a glucose perspective.
Post reply on HN