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GLP-1 drugs: An economic disruptor? (2024)

wildfirelabs.substack.com

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Re: GLP-1 drugs: An economic disruptor? (2024)

#531

Post by maxerickson »

aenis wrote: post #475
wert7886 wrote: post #469

Earlier quoted context omitted.

That sounds very intriguing, are you a bit concerned about the dropping vo2max ? Do you eat a lot more meat than before?

No, I eat a lot less in general and a whole lot of veggies. I followed the same routine 4 years ago, then I stopped and when I started eating carbs my vo2max recovered overnight . I think one cant have it all - either you run on stored energy which caps the power to weight ratio - or on readily available glucose and glycogen. Its fine, I am not an athlete, I do sports to feel good. I dont see an impact on raw strengt…

Do you mean aerobic performance in the last sentence?

Re: GLP-1 drugs: An economic disruptor? (2024)

#532

Post by mac-mc »

relaxing wrote: post #506
mac-mc wrote: post #483

Earlier quoted context omitted.

It's because people are different, sometimes on a genetic level. What works well for one person does not work well at all for another, like the parent commenter, I do not work well without carbs. Keto puts me in a low-energy, semi-depressed state, while eating +80% of my calories as starch led me to lose about 15lbs of fat and now I'm the lowest body fat % I've ever been in my adult and teen life and my HOMA-IR went…

Can you elaborate on the genetics part? What were the relevant SNPs?

It got a bit complicated; it was a long research project, and it led to me starting my current company, Patchwork. Currently, it's at a few hundred. https://www.patchworkfood.com

Re: GLP-1 drugs: An economic disruptor? (2024)

#533

Post by iheartblocks »

op00to wrote: post #438
galangalalgol wrote: post #310

Earlier quoted context omitted.

Ok I'd been considering it already, but now I'm sold. I have the transit time of a canid.

It’s wild. I’ve never experienced burping food and tasting what I ate earlier, food just kinda rolls right through. Now, I get to really enjoy it a second time.

Who needs an appetite suppressant when they have comments like these?

Re: GLP-1 drugs: An economic disruptor? (2024)

#534

Post by op00to »

iheartblocks wrote: post #533
op00to wrote: post #438

Earlier quoted context omitted.

It’s wild. I’ve never experienced burping food and tasting what I ate earlier, food just kinda rolls right through. Now, I get to really enjoy it a second time.

Who needs an appetite suppressant when they have comments like these?

Let me know when you need a little appetite adjustment. Free of charge!

Re: GLP-1 drugs: An economic disruptor? (2024)

#535

Post by dhfbshfbu4u3 »

slicerdicer2 wrote: post #478
dhfbshfbu4u3 wrote: post #408

Earlier quoted context omitted.

Nope. Just stuff they can use right now. No magic required!

GLP-1s have high quality double blinded placebo controlled RCTs proving them. Does anything else you mentioned?

Couple do, though long term studies on a few are missing.

RCT-Proven: GLP-1 Agonists, mTOR Modulation (Rapamycin), NMDA Modulators (Ketamine), Metformin.

Speculative/Limited Data: Senolytics, Hormones and Peptides, NAD+, Nootropics and Adaptogens.

Keep in mind that the absence of published RCTs does not mean an intervention is ineffective; it may just be proprietary knowledge. Plenty of rich, private labs out there doing that kind of work today.

Re: GLP-1 drugs: An economic disruptor? (2024)

#536

Post by petesergeant »

Henchman21 wrote: post #464
petesergeant wrote: post #452

Earlier quoted context omitted.

Stop moving up the dosage so fast.

I'm under the care of a physician, and my dose is fine, and managed by him, thanks :)

>> [it's] the hardest thing I've ever done for my health ... I've robbed myself of the one joy I had left and now I have none

> [but] my dose is fine [because] I'm under the care of a physician

Get a second medical opinion from a doctor experienced with prescribing these drugs.

Re: GLP-1 drugs: An economic disruptor? (2024)

#537

Post by kobenni »

cj wrote: post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

Interesting, this sounds like my normal state. I cope by only eating tasty calorie-dense meals and snacks, never skipping meals or snacks, and weight lifting to increase my appetite. Otherwise I become significantly underweight.

Re: GLP-1 drugs: An economic disruptor? (2024)

#538

Post by jredwards »

cj wrote: post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

How exactly does one get a prescription for that without any apparent need for it?

Re: GLP-1 drugs: An economic disruptor? (2024)

#539

Post by jredwards »

vjk800 wrote: post #456
cj wrote: post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

It's weird that I've never been overweight and you describe basically how I normally feel. I've never felt hungry in the morning. I've never eaten a lot. When I was younger, I often forced myself to eat more, because I felt bad about how I wasn't "big enough" (which feels silly now as a proper adult). Impulse buying food and snacking is something I only do if I haven't eaten for a long time, i.e. if I'm actually very…

I used to feel that way in my 20s. Things changed a lot when I hit 40.

Re: GLP-1 drugs: An economic disruptor? (2024)

#540

Post by codr7 »

cameronh90 wrote: post #66
nemo wrote: post #21

Earlier quoted context omitted.

My wife's taking GLP-1s for health reasons. The author's ideas about the effects of these things are not evidence based. It isn't a magic drug that makes people ascetics. She eats less, but she still impulse buys clothes and things. The idea that the drug numbs feelings is not at all what I see, while some appetites are diminished, we still both do art, enjoy going out doing all the same stuff as before. She's lost w…

I'm taking GLP-1s and it's absolutely reduced my impulsiveness in ways besides food. Not completely, for sure, and being less interested in food actually means more time to spend on other hobbies. But it's definitely done something to my non-food behaviour, albeit I'm not sure what exactly. It may well be that I was previously trying to satiate my constant desperate hunger for food with other forms of harmful addicti…

Sounds like a good case for keeping a detailed diary of emotional state to me.

The effects don't have to be dramatic to be harmful, subtle over time is arguably worse.

I just hope people keep their eyes open, that's all.

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