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Germany pauses AstraZeneca vaccinations as a 'precaution'

reuters.com

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Re: Germany pauses AstraZeneca vaccinations as a 'precaution'

#531

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Mh, do you really want to play down the possibility of unknown long-term consequences? Check out this: https://www.biorxiv.org/content/10.1101/2021.02.23.432474v1 The Spanish Flu has led to a „sleeping sickness“ epidemic years after it ceased.

There is nothing to play down. More than a year into the pandemic are there is still no evidence of long-term damage except in rare cases. Evidence of inflammation in monkeys does not qualify, before you ask.

CDC reports many kind of long-lasting adverse effects.

https://www.cdc.gov/coronavirus/2019-ncov/long-term-effects....

Re: Germany pauses AstraZeneca vaccinations as a 'precaution'

#532
post #402

Earlier quoted context omitted.

Yes, but herd immunity makes it possible to protect the total population from a disease including the ones that cannot get vaccinated, such as children or those with contraindications.

What's the COVID-induced death rate among children again?

I think it's something like .0000000000000004%

Re: Germany pauses AstraZeneca vaccinations as a 'precaution'

#533

Earlier quoted context omitted.

There is nothing to play down. More than a year into the pandemic are there is still no evidence of long-term damage except in rare cases. Evidence of inflammation in monkeys does not qualify, before you ask.

CDC reports many kind of long-lasting adverse effects. https://www.cdc.gov/coronavirus/2019-ncov/long-term-effects....

That page is useless, it doesn't mention how frequent the effects are.

Re: Germany pauses AstraZeneca vaccinations as a 'precaution'

#534

Earlier quoted context omitted.

I’m curious as to why you find the injection questionable? From my understanding, all of the vaccines approved in the US followed the same path every other vaccine follows. The difference was that Covid is everywhere, so stage 3 went really quickly, where it could normally take many months or years for the requisite amount of people to catch the disease in question. To me, these vaccines have been as rigorously teste…

Not that guy, but I'll give you one viewpoint. >To me, these vaccines have been as rigorously tested as they could be Not for me. The fact is, the vaccines have been pushed through faster than any vaccine before. Anything foreign entering the body should be tested and based on solid evidence. Doesn't matter if it's an artificial heart, stent, prosthetic, or a biological agent like a vaccine. If decades of medical res…

> The risk isn't worth it at this time.

This pandemic was never about the risk to this cohort that continues to be brought up. The point is that taking the vaccines reduces deaths. In places where these vaccines have been deployed widely, you cannot refute that statement. Just because the people who are dying don’t look like you does not diminish the utility of the vaccine.

I’m so tired of hearing that young people shouldn’t take the risk of vaccines because the risk to them of the virus is less. That is not why anyone at all is urging you to get the vaccine, or why we did any of this at all for a year.

A society is built on mutual trust and actions and speech like this shatter it; the selfish arguments seem to know no bounds in this pandemic. I did not sit in my damned house for a year because I was afraid for my own safety!

Furthermore, The article linked claims PCR testing isn’t good enough for efficacy and from what I understood had nothing to do with safety at all. In fact, the title of that submission includes “... REGARDING CONFIRMATION OF EFFICACY” and no mention of safety, but maybe I’m not “well-versed in science” enough to understand it. Thank you for talking down to me though, we would not want me to leave this conversation with a sense of self worth.

It seems to me like you’re unintentionally spreading disinformation. I assume you don’t want to be doing that, so you should probably check your priors here, as they seem to be outdated.

Re: Germany pauses AstraZeneca vaccinations as a 'precaution'

#535
post #530
post #526

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In a few more months everyone will be vaccinated, significantly limiting the spread, slowing mutation. To be clear, we’re talking about the risk of the AZ vaccine specifically. It seems like there might be something specifically wrong with it. Ceding approval authority to bodies like the FDA is how medicine is regulated all over the world. That’s how literal snake oil is blocked from sale. Among other things, it prev…

That's nice, and I suppose everyone entering and leaving the country will need vaccine passports. It's as if everything that we were told would never happen, is going to happen. "A few weeks to flatten the curve", and now we are swallowing the idea of 100% vaccination and associated papers. As for your comments on regulation - yes, that is correct, which is why I was surprised when I got so much flak for pointing out…

I guess I don’t remember things the same. In my state, the most extreme restrictions (basically, everything is closed that isn’t remote or essential work) were lifted after a bit. I don’t recall ever being under the impression that restrictions would ever be completely lifted until the vaccine was rolled out. I recall at the time there being a lot of worry about how long that would take. I also don’t recall anything about vaccine passports, other than China doing it. Maybe I wasn’t paying attention to the rhetoric surrounding that.

There were shortcuts taken in all countries to get the vaccines out. In the US, there is no FDA approved COVID vaccine. Every “approved” vaccine is actually under an emergency use authorization.

Re: Germany pauses AstraZeneca vaccinations as a 'precaution'

#536

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What you said about different strains has never been more than click-bait and conjecture. Please stopping spreading this, people are scared enough already. This is not how t-cell immunity and coronaviruses work [0]. From an article titled "Lab studies suggest Pfizer, Moderna vaccines can protect against coronavirus variant" I quote: "While the blood serum samples produced less neutralizing antibody activity, it was s…

If you have a well functioning immune system the vaccine should likely impart an advantage over no immunity and you have a good chance of fighting off the SARS quicker than without vaccination or immunity. The problem however is those with weak immune systems. In these cases, the vaccine is unlikely to help these people much, and they become breeding grounds for escape variants. It's like taking a quarter dose of an…

I'm not sure why you brought up immunocompromised people. Does that have anything to do with the video you linked? Seems like a wash, they are immunocompromised and anything they catch will have time to live and mutate in them, not just covid19. Maybe this is something separate we should set aside? Or I don't understand the relevance.

I watched enough of the video you sent to see what Dr. Bosche was saying - that vaccination immunity is more specific than natural immunity, and that may present problems down the road with variants. I also found this note/presentation/slides by him [0]. I read some of this to get more detail, video is kind of lame for relating so much information. I'm not a virologist. But I have read a bunch of this stuff. I thought what Dr. Bosche said was interesting. I had a few initial questions. I'd love to see more virologist's opinions on this.

He says "Covid-19, a highly mutable virus, only needs to add another few mutations in its receptor-binding domain". I didn't know that covid19 was considered highly mutable, like the flu. Is he hedging here, saying this might happen? I guess the specific proteins that the vaccines target would need to mutate. I wonder how likely this is. I assume there are lots of things that are "several mutations" away from killing us all. Papers I've seen early on said that left to its own covid19 had a 50/50 chance of mutating to become no more deaadly than the common cold (because it would spread better that way), or settle into something that flares up every few years, like a bad flu season. I took that to mean that there are also pressures to mutate to something less deadly. They think this is what may have happened in 1873 (if memory serves), a new coronavirus came on the scene, it looked like a very bad flu season at the time.

He mentioned several cases of young people dying from covid19 variants, and several cases of people shedding variants. "Several" is not a large number, especially considering how much we don't understand about the immune system. Typhoid Mary was shedding for years, and that had nothing to do with a vaccine. I don't know that I'd consider his several examples to be anything out of the ordinary out of a sample size of how many tens of millions.

He seems to be saying we'd be better off if we didn't proceed with vaccinations and allowed the population to reach natural herd immunity at this point, since covid19 has already spread to so many people. That people who caught it and got better on their own would be better protected. This reminds me of the virologist early on who recommended finding the least deadly variant and spreading that around on purpose.

It's an interesting topic, and I appreciate you bringing it up! I don't mean to argue over it, so much as relay my thoughts and left some of the details of what he's saying.

Do you think most of the people fearful of variants are on the same page with this guy? The news stories I see mentioning problems with vaccines and variants don't ever seem to have solid sources/studies backing them up, I've never heard this guy mentioned before, and he seems to be a relatively lone voice at this point. I'd like to think that the experts have had a chance to hash all this out amongst themselves, but I know things don't always work out that nicely.

[0] https://www.deblauwetijger.com/wp-content/uploads/2021/03/Ge...

Re: Germany pauses AstraZeneca vaccinations as a 'precaution'

#537
post #529

Earlier quoted context omitted.

The problem is that it's starting to look more and more like a production problem and a bad batch, and you shouldn't be vaccinated with a product that probably should have failed QA. It's not bureaucratic ass-covering, it's literally the protocol that's in place and has worked to keep populations safe. >250 miles of driving gives you a one in a million chance of death. This vaccine is safer than that. Again you're mi…

The alternative to a car with bad brakes or a plane with design flaws is another car or another plane. The alternative to a covid vaccine is that you get covid. Even for young and healthy people, that can mean debilitating long-term illness. There is no safe option here. We have to think like we are in war time, not peace time. Allowing people with informed consent to take this vaccine will save far more lives than b…

>The alternative to a covid vaccine is that you get covid. Even for young and healthy people, that can mean debilitating long-term illness.

Well that's arguable, I haven't had covid yet, and I don't plan on getting it. You had plenty of countries that handled covid without vaccines - we are where we are because western governments refused to take specific measures to control de pandemic (but this is another subject). So the alternative would be get a different vaccine.

Neither me EMA, or any regulator are advocating for not being vaccinated, I don't get where you're getting that from. The alternative to this vaccine is other vaccines, in EU alone 4 vaccines are approved and more are to come. Even AZ vaccine isn't excluded what so ever - they are investigating the potential cause.

>Allowing people with informed consent to take this vaccine will save far more lives than banning everyone from taking it.

Thankfully we have regulators that prevent such behavior. If there's a QA issue no one should be vaccinated with the batches affected by that, because proper QA seem to be without any of this reactions.

Re: Germany pauses AstraZeneca vaccinations as a 'precaution'

#538
post #441

Earlier quoted context omitted.

> and consider the fact that these numbers are what we see after a war-sized effort to prevent more damage Which doesn't seem to have worked - infection rates are dropping off all around the world, regardless of the vaccination levels. It looks more like we hit natural herd immunity at about the same time in different places whether or not masks and lockdowns were used.

The war-sized effort includes a lot of other things besides vaccines: lockdowns, masks, drastic reduction of international travel, tankerfuls of hand desinfectant, etc. Yes, then it starts to have an impact; without those, there would have been mayhem.

If all that - which was in place in late spring and summer last year - was the reason, then why did cases start increasing anyway in the fall?

For the two additional things you've mentioned: Limiting travel works to prevent the virus from entering an area, but if it's already there and uncontrolled it wouldn't have an effect. Likewise excessive hand disinfectant doesn't seem to have had an effect, because the virus doesn't really spread through surfaces like that [0] - it was an early precaution that wasn't reexamined.

[0] https://news.ycombinator.com/item?id=26000106

Re: Germany pauses AstraZeneca vaccinations as a 'precaution'

#539
post #433

Earlier quoted context omitted.

> The EMA has said that as of March 10, a total of 30 cases of blood clotting had been reported among close to 5 million people vaccinated with the AstraZeneca shot in the European Economic Area, which links 30 European countries. "The decision today is purely precautionary..." given this level of signal. We don't have details on the age groups involved and the normal rates expected but I can hazard a Fermi Estimate…

It's 0.0015% compared to 4%, so at least a 2.6·1e3 difference. Given less than 0.004% chance to catch the disease in my city, the odds are 10 fold in favour of not getting vaccinated. I'll still get vaccinated regardless, because I am sick and tired of this pandemic and want to go on vacation instead of into an another lockdown this year.

Where are you getting 4% from? It looks to me like like 3 deaths out of 1.2m vaccinated.

(I’m looking at the linked PDF https://www.pei.de/SharedDocs/Downloads/EN/newsroom-en/hp-ne...)

Re: Germany pauses AstraZeneca vaccinations as a 'precaution'

#540
post #190

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I'm set to take the oxford d vaccine, but I could also take the pfizer vaccine. I've had elevated blood markers for clotting during covid-19, and now I hear of this. I'm thinking of taking 75 mg aspirin, before and after the vaccine. On the other hand, the issue is the patients have low platelet count and I understand that this is the way aspirin reduces blod clotting. So, do these patients have low platelet count be…

Talk to your doctor before making decisions. Taking aspirin right before a vaccine might not be a good idea as it can blunt your immune system response, but the whole point of a vaccine is to elicit a strong immune response that builds memory. I know acetaminophen is specifically mentioned as something not to take right before the COVID-19 vaccines (and afterwards, if you can deal with the immune response naturally).

AFIK, the dosage for blood thinning properties is 75mg, anti-inflammatory dosage is much higher.

I'm not worried about blunted immune response because I've taken heaps of asprin when I had COVID-19 (it might be why I got tinnitus for close to 6 months afterwards -- that or the antibiotics) and I mean grams per day and I had very high antibodies levels afterwards.

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