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Ozempic shows anti-aging effects in trial

trial.medpath.com

521–530 of 868 posts

Re: Ozempic shows anti-aging effects in trial

#521

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

I don't think it is unequivocally a good thing, but it is probably significantly less bad for you than being morbidly obese.

Re: Ozempic shows anti-aging effects in trial

#522

Earlier quoted context omitted.

Many people (will only speak to America), view being fat as a literal moral failing. Gluttony or overeating are not the sin, but being fat. (From that perspective:)a miracle cure that allows someone to stop being fat is like an indulgence (in the Roman Catholic sense). It’s a cheat, a shortcut that allows the unworthy to reach a state they do not deserve. My opinion is to wait long enough to validate there are no lon…

> Many people (will only speak to America), view being fat as a literal moral failing. Gluttony or overeating are not the sin, but being fat. I feel like I've seen and heard more of the opposite: The trend is to avoiding anything that might make someone feel blame for arriving in their situation. With obesity the trend is to blame some combination of "our food supply", trending science topics like microplastics or th…

Primary source on Yud's weight-loss efforts: https://www.lesswrong.com/posts/udFuYqqNdpdo5ym3f/?commentId...

Re: Ozempic shows anti-aging effects in trial

#523

Earlier quoted context omitted.

I helped my dad lose 50 lbs by finally, after 10 years, getting him to give up bread, sugar, potatoes. It took buying him 2 months of a bluetooth glucose monitor. Once he saw what certain foods do, he believed me finally. At 65 years old, healthier than I remember since he was 40 and I was a teen. It doesn't require some weird injection.

There's anecdotes, and there's science. Individually, there's (previously) been nothing better to suggest than "try harder (and, maybe, smarter)". Statistically it was almost useless, but it's the best we had. It's not bad advice exactly, it's just extremely unlikely to work for long-term, sustained weight loss. It also very much appears to be the case that weight gain and loss are heavily influenced by environmental…

you are taking in more calories than you are burning off, for whatever reason. its that simple

Re: Ozempic shows anti-aging effects in trial

#524

Earlier quoted context omitted.

Honestly, this is essentially BS. I'd say that 95% of healthy weight people stay that weight because their metabolism and appetite works properly. People who stay in shape by paying careful attention to their diet are a tiny minority.

What information do you have to back up this claim?

Eh, most people just wing it at everything. Including diet.

Source: have to do keto diet and be strict to stop food addiction.

Re: Ozempic shows anti-aging effects in trial

#525

Earlier quoted context omitted.

> If Ozempic is so great then how come our bodies don't just produce more GLP-1? To store calories so you don't starve. This is a failure mode of evolution and there is in fact "free lunch" when we use technology to reoptimise our bodies to calorie abundance

> when we use technology to reoptimise our bodies to calorie abundance replace "calorie abundance" with "sedentary lifestyle" and youre there. its people eating more than they burn off because they dont exert themselves because thats what being an adult means.

[deleted]

Re: Ozempic shows anti-aging effects in trial

#526

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

I think it's because their use comes across for many users as lazy. It reflects poorly on peoples state of discipline and willpower. I wouldn't judge somebody morbidly obese using these to get down to a lower weight to healthily exercise and eat less. But I definitely judge people who are taking these who are only marginally overweight or actually normal weight.

Imagine kids that want to eat chicken nuggets and sweets and don't want to do any exercise because it's hard or makes them briefly uncomfortable. Then apply that image to people over the age of 10.

When I started gaining weight in the past, I changed my diet (permanently up to this point) and got set on a fitness path. These things greatly improved my life and improved my outlook on life. Somebody who just grabs an injection isn't getting that same change in outlook. They're just handling the symptoms instead of addressing the root cause.

Re: Ozempic shows anti-aging effects in trial

#527
post #511

Earlier quoted context omitted.

Is it possible to avoid having the same discussion every time anything related to Ozempic comes up?

It's an important discussion. We should all be aiming to do better. Instead we're just lowering the standards for everything. Only the morbidly obese should be using these drugs to get down to a healthy enough (overweight) level to lose the rest with sensible discipline, healthy/less eating (mostly this), and exercise (less this, but important for the mind, strength and cardio). Discipline and basic understanding of…

Nah man. I'm overweight and despite trying everything I possibly can for most of my adult life, I still can't win. I do everything you're supposed to do but it's just not possible to maintain long-term. It's a constant struggle. You don't have discipline. It's just easier for you. That's all. I still won't use this drug but don't try to tell me I failed because of a lack of effort, understanding, exercise, "discipline", etc.

Re: Ozempic shows anti-aging effects in trial

#528
post #503

This, like much of the pharmaceutical approach to well-being, is treating symptoms and not the problem. Metabolic dysfunction? Fix the metabolism. Poor understanding of nutrition? Fix the understanding. Lack of emotional or self-control? Fix the discipline. Obesity is largely NOT an acute symptom and does not need an acute solution. If you don't fix the underlying problem you will have weight issues your whole life (…

Wow, I didn't realize the solution to all my problems is just to fix them. The answer was staring me right in the face the entire time.

While I'm at it, I should also not take ADHD medication and instead just fix my mutated dopamine circuitry.

Re: Ozempic shows anti-aging effects in trial

#529
post #503

This, like much of the pharmaceutical approach to well-being, is treating symptoms and not the problem. Metabolic dysfunction? Fix the metabolism. Poor understanding of nutrition? Fix the understanding. Lack of emotional or self-control? Fix the discipline. Obesity is largely NOT an acute symptom and does not need an acute solution. If you don't fix the underlying problem you will have weight issues your whole life (…

> Metabolic dysfunction? Fix the metabolism.

What specific diagnosis is a "metabolic dysfunction", and how is it fixable?

Re: Ozempic shows anti-aging effects in trial

#530
post #79

Earlier quoted context omitted.

There are lots of miraculous, life-saving drugs that have minimal side effects and aren't snake oil. Metformin, insulin, many vaccines, some statins, and some antibiotics are clearly on that list.

Statins cause uncontrollable anger in some people… but also lower it in other people. eg https://journals.plos.org/plosone/article?id=10.1371/journal... finds it reduces anger in men but increases it in women.

Sure, but most people take statins without side-effects
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