Earlier quoted context omitted.
I fully agree with your analysis of the shortcomings of the academic system, but that's really a lame response and suggests that you didn't think this through. We're not talking about people in their early twenties who can invest some years in crazy experiments without fearing the consequences. Researchers at that stage have invested a substantial chunk of their lives in their careers and many of them have families t…
The world would be a better place if more people took career risks. The evidence is that the majority of interesting stuff was created by people taking big career risks, even though they're a minority of all researchers. So people who take career risks are more likely to create something great. It sucks to lose at a career gamble but, at least in Silicon Valley, most people who fail but keep trying, end up doing pret…
It's easy to say that "more people" should take career risks. It's harder to be the person who's spent their entire life striving toward a Ph.D. in the field of study they love, and face the (very real) possibility that they'll get one shot and that's it.
Even if they can land at a Silicon Valley company (not as likely for biomedical researchers, BTW), that's not their dream. Their dream was to do groundbreaking scientific research. That's why they got their Ph.D. instead of a job in Silicon Valley.
I don't think Sam addressed the commenter's concerns at all.