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Prozac 'no better than placebo' for treating children with depression, experts

theguardian.com

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Re: Prozac 'no better than placebo' for treating children with depression, experts

#511

Earlier quoted context omitted.

the alternative is depression. brain altering drugs seem preferrable

The dichotomy of such mental illness is people with more constitutional resilience just say "power through?" and they are absolutely correct, it is something they can power through. Mentally ill folk literally cant, not in em. There are right answers to help them, but that's not the right one. It's kind of like telling someone who is color blind to squint real hard, won't ever help. Myself, I'm someone very much in t…

There are many mentally ill people who "power through", though. Some call it high-functioning depression.

There are different severities - a small depressive episode, a multi-year dysthymia or mixed (manic + depressive) episode.

I've been managing OK without meds, but maybe simply depression wasn't as severe as that of other folk. It's still a mental illness.

However, the effectiveness of Mindfulness based stress reduction and acceptance & commitment therapy show that those who can distance themselves from their thoughts have developed "mental resilience"

Re: Prozac 'no better than placebo' for treating children with depression, experts

#512
post #172

My own experience with SSRIs was very unpleasant. Sure, it worked to reduce my anxiety problems while I was on them for years. The first year I was off of them was the worst though. I didn't have that bad anxiety ever, as in constant panic and feeking of impeding doom. This made me realize that they aren't really an option of me. So began my long therapy journey. After 7 years of weekly therapy, a healthy work-life b…

I hear this story over and over again and it makes me sad. Medication for depression, anxiety, or adhd should be used to enable the work with a therapist, not to make life bearable without working on the underlying problems. Been there, done that. Wasted a couple of otherwise good years on not doing the work.

Re: Prozac 'no better than placebo' for treating children with depression, experts

#513

Earlier quoted context omitted.

Is that the only alternative?

Therapy is effective, but not always. sometimes, especially with children, there is no root cause in life to the depression beyond "genetics". Additional, therapy may simply be useless and unproductive without medication being used concurrently. There's also simply death. I didn't feel like mentioning it, but I think its worth pointing out that without treatment, death is a very real possibility.

>sometimes, especially with children, there is no root cause in life to the depression beyond "genetics".

I find this hard to believe. People in the past weren't depressed nearly as much, so whatever is causing it has to be environmental.

Re: Prozac 'no better than placebo' for treating children with depression, experts

#514
Its not just children, its adults too. Because of the FOIA we have seen the studies these drug companies made disappear and this applies to probably every single antidepressants. Keep in mind the placebo effect happens in about 30% of people which are the people that think it works and then eventually stops working.

Re: Prozac 'no better than placebo' for treating children with depression, experts

#515

Earlier quoted context omitted.

This all started with someone asking for their sources, and the person hasn't given any except to say to Google... which means for all we know the person who then googled ended up in a situation with lots of conspiracy theories. Google famously gives personalized results to an extreme degree especially when you add in differences in search terms. I will say if you search for "chemical imbalance debunked" as discussed…

[flagged]

Yeah, the person making the claim never responded. But I was more responding to your comments, specifically:

"Just searching 'chemical imbalance debunked' yields a wide array of sources. So why ask?", and "One of the first search results for me was a paper published in Nature. Other top results were from respected institutions like the NIH and Harvard University. Hardly grifters or crazies."

Those both trivialize the process of finding sources and interpreting them. I picked my top result which was from nih.gov and gave an example of why it's hard for a lay-person to interpret journal entries because it uses field specific terms that come across as wrong or conspiratorial. Heck the paper itself references other papers on other journals that appear legitimate that argue for the chemical imbalance theory, eg an article from JAMA (Journal of the American Medical Association) from 1993. Just because the source has NIH in it or is in a journal does not guarantee correctness or reliability because time passes and new science is done. The link in question was of a paper from 2006, which we are now further from than the 2006 paper was from the 1993 paper.

I am not claiming to be a scientific luminary and even agree that the chemical imbalance theory that was espoused for years was probably incorrect for many issues. I was just arguing against thinking it's easy to investigate and source claims. It's much easier for the person who is making the claim to provide their sources, and preferably they have a large body of evidence behind them and are recent or even better a source that has done that leg work of reviewing it and distilling it down.

Re: Prozac 'no better than placebo' for treating children with depression, experts

#516

Earlier quoted context omitted.

I have seen no studies that suggest such a thing. Hoards of studies suggest religion is good for mental health. I can be persuaded, though. Can you show research?

For whose mental health? My point is that religion brings its own shared of issues. And by religion here I mean organised religion. Religions that don't involve rituals or gatherings with other people in hierarchical settings are different (but I assume most people are after rituals and gatherings with other people in well defined settings imo rather than the actual metaphysical beliefs). - If you look at highly reli…

Thank you for the conversation.

The first 3 links you’ve provided discuss mental health as it relates to geography, not religion. To be sure, religion is associated with those geographic areas, but so are numerous other factors like race, income, etc etc.

The next links are closer to target, they talk about religious objections to medical treatments and the adverse affects upon kids. Nobody should deny this is a real problem, but fortunately it is a very small problem. ( One of the studies found only 172 fatalities over 20 years, and even estimated 10% of the kids may have died anyway.). So I’ll grant that is a real problem, but not one that affects many people. With luck, perhaps it will get better over time.

The next study is interesting, but again very limited. It has 6k subjects, but these are only with religious mothers and only in the UK. This study cites prior study that concluded “ an individual's religiosity is consistently, positively related to their own mental health in US samples”.

The next study associated suicidal tendencies with a very narrow aspect of religion, and even then self reported: “We recruited a relatively small sample that was geographically, racially, and socioeconomically homogenous. We also relied solely on self-report data.”

The next study does not seem to help your argument. It deals with religious beliefs in cancer patients and says “Higher levels of religiosity and spirituality are associated with reduced risk of suicidality and suicidal behaviors [29–31], including in advanced cancer patients “

The final link is just a case study about a single suicidal pastor. It concludes with a paragraph that says “Although there are studies showing that religious people are less prone to suicide…”

So I can’t say all that changes the findings of the many studies that conclude religion is good for mental health.

Re: Prozac 'no better than placebo' for treating children with depression, experts

#517
post #361

Earlier quoted context omitted.

And several of your comments before that were upvoted. Are we to regard those as suspicious? Of the recent downvoted comments, one was a complaint about moderation that anyone who has paid attention to dang's track record here over more than a decade knows is baseless. (And if you think the top comment on any thread is a bad one, you can always choose to be a helpful contributor to the community and email us to let u…

> when things don't go your way, You're a ridiculous person. > or alternatively to keep using HN for political/ideological battle Which ones? The one about ML and programming languages? Or the one about asking a genuine question about an experience with childhood depression? Or the one observing that you and dang unevenly apply moderation rules? Or the one commenting about how you can't say the word for the literal d…

I've scanned your full list of comments and can find plenty that have an ideological flavor to them, and others that are in the flamewar style, but are not so clearly related to politics/ideology. I'm not interested in getting into an argument about which of your comments are ideological or not. That's not the issue. What is the issue is the hostile and inflammatory style of commenting towards other community members and HN as a whole.

It's notable in this instance:

- You posted a series of comments about controversial topics, having established a history of participating on HN with this persona of being a brave combatant for, I don't know, some worldview or philosophy that you seem to be fighting for;

- When a handful of your comments receive even a solitary downvote, you call in "the cops" (dang) to come to your aid, with a claim of "brigading";

- When we investigated and found that, no, there's no "brigading", some of those comments are not even net-downvoted anymore, and that any downvotes you're getting are to be expected given your combative style of commenting, you've responded with these incoherent attacks on moderation/moderators.

Whether we all agree that many of your flamewar-style comments really are, in fact, political/ideological, is not the point and seems to be a way for you to deflect from being held to account for your conduct.

What I'm saying to you is that people who care about making HN better have all kinds of ways of showing it, and it begins with making an effort to observe the guidelines, and it also involves engaging respectfully with other community members and the moderation system. We are always, always working to make HN better and our moderation approaches better, and we always welcome and engage with feedback, as dang has been doing with you in another subthread today. But we've both been doing this job long enough to sense when someone isn't really wanting to help make HN better at all.

Re: Prozac 'no better than placebo' for treating children with depression, experts

#519

Earlier quoted context omitted.

Murder is a very successful cure to a lot of ailments.

I feel like you're not getting the very obvious implied point in that no one thinks lobotomy was good practice in retrospect

The guy I replied to seemed to, after I mentioned lobotomies as an example of physical treatments for "feeling sad" that are now seen as barbaric.

Re: Prozac 'no better than placebo' for treating children with depression, experts

#520
post #507

Earlier quoted context omitted.

Note that the black box warning has nothing to do with long-term effects of the medication. It was added specifically because kids were killing themselves within weeks of starting the medication. > This is one of the most shocking things I have ever read. Good grief. I hope you're exaggerating for effect.

> Note that the black box warning has nothing to do with long-term effects of the medication What are the long-term effects of suicide? A 7-year-old kid doesn't understand what suicide really means. Putting them on something that encourages a behavior that they don't understand and has completely catastrophic results isn't a risk I would take with my children.

I respectfully submit you might feel differently about it if your child were suicidal. When someone has to be watching them 24/7 already for fear they'll hurt themselves, the black box warning is a lot less worrisome. SSRIs prevent more suicides by far than they cause. It's that first few weeks where they can have a paradoxical effect.
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