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Scientists may have found a way to eliminate chromosome linked to Down syndrome

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Re: Scientists may have found a way to eliminate chromosome linked to Down syndrome

#501

Earlier quoted context omitted.

> One way to define a human is any living entity that is either an adult human, or will/would grow into an adult human as long as no problem has happened or will happen to the entity. A few posts back you complained about "tail-wagging-the-dog" thinking, where one reasons backwards from the conclusions one wishes to reach. Your definition is obviously a product of that style of thinking: instead of clarifying what is…

>But if an unfertilized egg dies due to not being fertilized, I'm sure you would argue that "not being fertilized" doesn't count as a problem; or alternatively, that the fertilized egg is a different entity from the unfertilized egg. But none of this follows naturally from the definition, it requires our notions of "problem" and "entity" to be perfectly aligned to begin with. And you will pick your understanding of "…

> I think there's a clear biological difference between an entity receiving nutrition, and 2 entities, each with half of a set of DNA, coming together to make a single entity with a full set of DNA.

The difference is "clear" to you because you are reasoning backwards from a desired conclusion. You want to claim that the zygote is a person and the unfertilized egg is not, so of course the merger of DNA is the "clear" boundary between entities to you.

But this boundary just doesn't work very well. To begin with you ignored the "child with deadly mutation" challenge I presented: the only way the child reaches adulthood is if we modify its genes, which you seem to imply makes it a different entity.

And if we dig a bit deeper, the criterion by which you disqualify the unfertilized egg from being considered human also disqualifies the fertilized egg. It too is an entity which can meld with other entities to form a single entity (chimerism, as we discussed), and it can even do the opposite: identical twins start as one zygote that splits at a later point in its development.

I'm not sure even adult humans would qualify for being human in your worldview, come to think of it. Some people have had their brain halves separated during their lifetime, and this seems to lead to two separate persons locked in one body, at least in some cases (https://en.wikipedia.org/wiki/Split-brain).

At this point, you can start overfitting your definition to draw an absurdly jagged boundary exactly around these counterexamples, but at that point I'd appreciate if you just admit that personhood starting at fertilization is just an axiom for you and everything else follows from it.

> What you're saying seems to be that it's ok for the state to mandate citizens protect the state, but not ok for the state to mandate citizens protect the people in the state.

That is very much not what I am saying, but I wasn't very explicit about the point I was making, so I shall clarify.

Two people can disagree about what they think the law should say, but one thing that all decent people would agree on, is that the law should be consistent. We want it to apply evenly to all, without strange exceptions. We don't want any laws that say "everyone is free, except people born in May, they have to do slave labor in the mines."

I was not making an argument about what the law should be, I was arguing that abortion laws make the law inconsistent, as there is no other case where the state violates the bodily autonomy of one person to force them to care for another. For example, if we are in a remote area and I get badly injured, and you are the only person with a compatible blood type nearby, the state can't force you to donate your blood to me.

My point was that it's inconsistent to say that the state can violate one person's bodily autonomy to keep another alive specifically in the case of pregnancy. If you want to make this consistent, you need to allow the state to do this in all cases, implying among other things forced blood transfusions and forced kidney donations. Perhaps you agree that the state should be able to force people to donate blood or a kidney, and in that case your opinion is consistent.

I wasn't expressing agreement or disagreement with the draft. I was stating that it is irrelevant as a counterexample. That's because the justification for the draft rests on a moral principle that's distinct from the one that justifies abortion laws (ie "citizens' bodily autonomy can be violated to defend the state" vs "citizens' bodily autonomy can be violated to save any individual's life"). Again, I deliberately offer no opinion on whether the draft is justified; for my purposes it's enough to show that it is not relevant as a counterexample.

Re: Scientists may have found a way to eliminate chromosome linked to Down syndrome

#502

Earlier quoted context omitted.

I'm wary of classifying any group as partial people. That's been used as a justification throughout history for causing harm to groups of people. >We don’t initially, as infants, know the difference between our body and the world. Does this make infants not people? No, not legally or morally, but in some sense they lack aspects we’d associate with personhood. I agree. I think this supports my view, that someone can b…

In my opinion, they’re legally and morally treated as a person because it works in society, not because it expresses something fundamental about child development. It’s not an argument against abortion. >I'm wary of classifying any group as partial people. I think you need to in certain areas if you want to understand the world better is all. A braindead person isn’t the same as a non-braindead person, and there’s li…

>In my opinion, they’re legally and morally treated as a person because it works in society, not because it expresses something fundamental about child development. It’s not an argument against abortion.

Maybe I'm misunderstanding. You seem to be agreeing there's not much difference between a fetus and an infant. But you're saying that this isn't an argument against abortion, because... are you saying killing a born infant is ok?

Re: Scientists may have found a way to eliminate chromosome linked to Down syndrome

#503

Earlier quoted context omitted.

>But if an unfertilized egg dies due to not being fertilized, I'm sure you would argue that "not being fertilized" doesn't count as a problem; or alternatively, that the fertilized egg is a different entity from the unfertilized egg. But none of this follows naturally from the definition, it requires our notions of "problem" and "entity" to be perfectly aligned to begin with. And you will pick your understanding of "…

> I think there's a clear biological difference between an entity receiving nutrition, and 2 entities, each with half of a set of DNA, coming together to make a single entity with a full set of DNA. The difference is "clear" to you because you are reasoning backwards from a desired conclusion. You want to claim that the zygote is a person and the unfertilized egg is not, so of course the merger of DNA is the "clear"…

>The difference is "clear" to you because you are reasoning backwards from a desired conclusion. You want to claim that the zygote is a person and the unfertilized egg is not, so of course the merger of DNA is the "clear" boundary between entities to you.

I'm not making up this boundary. This is the scientific definition of an organism.

>To begin with you ignored the "child with deadly mutation" challenge I presented:

The deadly mutation would be the "problem [that] has happened or will happen to the entity." So it doesn't contradict my previous definition. Regardless of whether the deadly mutation could be fixed by gene modification or not, the child is still a person.

>if we modify its genes, which you seem to imply makes it a different entity.

I don't think I said that.

>And if we dig a bit deeper, the criterion by which you disqualify the unfertilized egg from being considered human also disqualifies the fertilized egg. It too is an entity which can meld with other entities to form a single entity (chimerism, as we discussed), and it can even do the opposite: identical twins start as one zygote that splits at a later point in its development.

I'm not sure either of those contradict my previous definition. The chimerism can be considered a problem that will happen. Regarding identical twins, we could argue whether "grow into an adult human" covers "grow into 2 adult humans" or not.

We can modify the definition slightly to avoid these ambiguities: "Any living entity that is either an adult human, or will/would grow into an adult human as long as no problem has happened or will happen to the entity and the typical development process proceeds."

>I'm not sure even adult humans would qualify for being human in your worldview, come to think of it. Some people have had their brain halves separated during their lifetime, and this seems to lead to two separate persons locked in one body, at least in some cases (https://en.wikipedia.org/wiki/Split-brain).

I'm not sure how that situation in any way would lead to a strange interaction with my definition (old or new definitions). My definition would classify that person as a person.

>but at that point I'd appreciate if you just admit that personhood starting at fertilization is just an axiom for you and everything else follows from it.

The axiom for me is that there's no such thing as a partial person. From that axiom, the only logical conclusion I can see is that personhood begins at fertilization.

>as there is no other case where the state violates the bodily autonomy of one person to force them to care for another.

What about child neglect laws? Those restrict the parents' autonomy.

>For example, if we are in a remote area and I get badly injured, and you are the only person with a compatible blood type nearby, the state can't force you to donate your blood to me.

Generally the state's laws forbid one person from taking actions that would violate the rights of another person. For example, if I'm dying and need a kidney, it's not legal for me to forcefully take a kidney from someone else, even if that's the only way to preserve my bodily rights (avoiding death).

I think that is consistent to the state making it not legal for a mother to kill a fetus (assuming the state views the fetus as a person), even if that's the only way for the mother to preserve her bodily rights.

Re: Scientists may have found a way to eliminate chromosome linked to Down syndrome

#504

Earlier quoted context omitted.

In my opinion, they’re legally and morally treated as a person because it works in society, not because it expresses something fundamental about child development. It’s not an argument against abortion. >I'm wary of classifying any group as partial people. I think you need to in certain areas if you want to understand the world better is all. A braindead person isn’t the same as a non-braindead person, and there’s li…

>In my opinion, they’re legally and morally treated as a person because it works in society, not because it expresses something fundamental about child development. It’s not an argument against abortion. Maybe I'm misunderstanding. You seem to be agreeing there's not much difference between a fetus and an infant. But you're saying that this isn't an argument against abortion, because... are you saying killing a born…

Nope, you’re reading way too far into it. Given that born infants almost certainly possess a kind of “partial personhood,” the reason we assign them full personhood isn’t out of recognition of observable fact, but out of practicality and necessity. It wouldn’t make sense to structure society in such a way that newborns weren’t people, and would likely result in lots of moral harm. The idea of partial personhood doesn’t work in law or politics, even if its biologically founded, so we should choose a cutoff point that makes the most sense and prevents the most harm before which we don’t consider fetuses people, and after which we do.

Re: Scientists may have found a way to eliminate chromosome linked to Down syndrome

#505

Earlier quoted context omitted.

>In my opinion, they’re legally and morally treated as a person because it works in society, not because it expresses something fundamental about child development. It’s not an argument against abortion. Maybe I'm misunderstanding. You seem to be agreeing there's not much difference between a fetus and an infant. But you're saying that this isn't an argument against abortion, because... are you saying killing a born…

Nope, you’re reading way too far into it. Given that born infants almost certainly possess a kind of “partial personhood,” the reason we assign them full personhood isn’t out of recognition of observable fact, but out of practicality and necessity. It wouldn’t make sense to structure society in such a way that newborns weren’t people, and would likely result in lots of moral harm. The idea of partial personhood doesn…

My worry is that if infants are only partial people, then people might come up with arguments that it's ok to kill them in some situations. And it opens the door to start classifying other people as partial people (e.g. disabled people). Which is why I say there's no such thing as a partial people.

Re: Scientists may have found a way to eliminate chromosome linked to Down syndrome

#506

Earlier quoted context omitted.

> I think there's a clear biological difference between an entity receiving nutrition, and 2 entities, each with half of a set of DNA, coming together to make a single entity with a full set of DNA. The difference is "clear" to you because you are reasoning backwards from a desired conclusion. You want to claim that the zygote is a person and the unfertilized egg is not, so of course the merger of DNA is the "clear"…

>The difference is "clear" to you because you are reasoning backwards from a desired conclusion. You want to claim that the zygote is a person and the unfertilized egg is not, so of course the merger of DNA is the "clear" boundary between entities to you. I'm not making up this boundary. This is the scientific definition of an organism. >To begin with you ignored the "child with deadly mutation" challenge I presented…

> I'm not making up this boundary. This is the scientific definition of an organism.

To begin with, you did not volunteer a definition for the term "organism"; you limited yourself to attempting defining "human". This was rhetorically a good move, because defining the term "organism" is significantly harder.

You keep repeating that your definition is scientific, but offer no evidence of this. I argue that no such definition exists. The wikipedia page for the term "organism" starts as follows:

> An organism is any living thing that functions as an individual. Such a definition raises more problems than it solves, not least because the concept of an individual is also difficult. Several criteria, few of which are widely accepted, have been proposed to define what constitutes an organism.

> > if we modify its genes, which you seem to imply makes it a different entity.

> I don't think I said that.

> >And if we dig a bit deeper, the criterion by which you disqualify the unfertilized egg from being considered human also disqualifies the fertilized egg. It too is an entity which can meld with other entities to form a single entity (chimerism, as we discussed), and it can even do the opposite: identical twins start as one zygote that splits at a later point in its development.

> I'm not sure either of those contradict my previous definition. The chimerism can be considered a problem that will happen. Regarding identical twins, we could argue whether "grow into an adult human" covers "grow into 2 adult humans" or not.

You forget that my statement was a reply to something you said after you stated your definition. You argued that an unfertilized egg cannot be considered a person because it is "clearly" a different entity from the fertilized egg. That does not follow from your definition, because you don't define the term "entity" anywhere.

All my counterexamples were further attempts to divine what you mean by "entity" (which is an absolutely load-bearing concept in your definition which, again, you leave undefined). If you object to the unfertilized egg being the same entity as the fertilized egg, my hypotheses about your understanding of "entity" are that either changing the genome means that it becomes a different entity (generating the deadly mutation challenge), or merging two entities makes them a distinct entity from either original (generating the chimerism example).

My reasoning was a bit loose regarding the identical twins and split-brain examples: I implicitly generalized your potential objection to mergers to an objection to changes in cardinality. I personally don't see why one would reject mergers but accept splits, but that's not an inconsistent position.

At the moment I still don't know why you believe the unfertilized egg is necessarily a different entity from the zygote. Your response to the chimerism example provides no clarification on this: I was clearly challenging your notion of entity, but you responded only with that it "can be considered a problem that can happen".

> The axiom for me is that there's no such thing as a partial person. From that axiom, the only logical conclusion I can see is that personhood begins at fertilization.

I strongly disagree with this axiom. At some point in the distant past, our ancestors were non-human (and, possibly but not necessarily at the same time, not persons). The logical conclusion from your axiom is that there was, at some point, a hard boundary where an entirely nonperson animal gave birth to a "full person" human (and that first human then presumably had to reproduce through bestiality, unless through some amazing fortune another full 100% human being was born and fertile during their fertile years).

This seems to me a significantly less reasonable reading of reality than describing this as a gradual process towards personhood/humanity, where each successive generation is "more personlike". I find this also a more moral reading of reality: to me clearly an ape or an octopus is more personlike than a cockroach, which is in turn a bit more personlike than a jellyfish, which is a tiny tiny bit more personlike than a sea sponge.

> What about child neglect laws? Those restrict the parents' autonomy.

Correct. But it does not restrict their bodily autonomy. I don't think parents can be forced to donate blood or organs to their offspring. Of course most would without a second thought, but not because it is obligated by law.

> Generally the state's laws forbid one person from taking actions that would violate the rights of another person [...] I think that is consistent to the state making it not legal for a mother to kill a fetus [...]

There's a contrived "standard thought experiment" that responds to this: suppose A kidnaps B, ties them down, and connects B's bloodstream to an entirely innocent C with kidney failure, so that B's kidneys process C's blood. Disconnecting B from C will result in the death of C (assume there is no way around this). In this case the status quo is that B is keeping C alive, and it requires active intervention to change this situation. Does B now have a moral duty to remain physically connected to C at all times? Does B "kill" C if they disconnect the bloodstreams?

If you believe that it is, your opinion is consistent. If it's not, then you must at least permit abortion in the case of rape, even if the fetus is a person.

Re: Scientists may have found a way to eliminate chromosome linked to Down syndrome

#507

Earlier quoted context omitted.

Nope, you’re reading way too far into it. Given that born infants almost certainly possess a kind of “partial personhood,” the reason we assign them full personhood isn’t out of recognition of observable fact, but out of practicality and necessity. It wouldn’t make sense to structure society in such a way that newborns weren’t people, and would likely result in lots of moral harm. The idea of partial personhood doesn…

My worry is that if infants are only partial people, then people might come up with arguments that it's ok to kill them in some situations. And it opens the door to start classifying other people as partial people (e.g. disabled people). Which is why I say there's no such thing as a partial people.

But that was precisely my point. We shouldn’t classify anyone as partial people, which means we need to draw an intelligently chosen line separating the two. Choosing fertilization as this point seems irrational to me, and the consequence of this irrational choice harms an enormous number of women.

Re: Scientists may have found a way to eliminate chromosome linked to Down syndrome

#509

Earlier quoted context omitted.

>The difference is "clear" to you because you are reasoning backwards from a desired conclusion. You want to claim that the zygote is a person and the unfertilized egg is not, so of course the merger of DNA is the "clear" boundary between entities to you. I'm not making up this boundary. This is the scientific definition of an organism. >To begin with you ignored the "child with deadly mutation" challenge I presented…

> I'm not making up this boundary. This is the scientific definition of an organism. To begin with, you did not volunteer a definition for the term "organism"; you limited yourself to attempting defining "human". This was rhetorically a good move, because defining the term "organism" is significantly harder. You keep repeating that your definition is scientific, but offer no evidence of this. I argue that no such def…

> Such a definition raises more problems than it solves,

That's a good point. However, none of the examples of situations where the definition is debatable apply to humans. The page lists viruses, colonial organisms, zooids, and collaboration organisms. I think for humans (which I think is the most widely studied organism), scientists can clearly define what is an organism and what isn't.

I think if you were to survey biologists, the vast majority (95%+) would agree with me on all the cases ("is this specific thing a human organism") you listed.

>"entity" (which is an absolutely load-bearing concept in your definition which, again, you leave undefined)

Ok. Let's define it as "a cell or group of cells that are joined together and acting together".

>You argued that an unfertilized egg cannot be considered a person because it is "clearly" a different entity from the fertilized egg.

I said "I think there's a clear biological difference between an entity receiving nutrition, and 2 entities, each with half of a set of DNA, coming together to make a single entity with a full set of DNA."

My point was that there's a clear difference between receiving nutrition and 2 entities with half a set of DNA coming together. My point wasn't that the unfertilized egg and fertilized egg are clearly different entities (as you've pointed out, that's not exactly clear, and depends on the definition entity).

My definition doesn't hinge on the unfertilized egg and fertilized egg being different entities. An unfertilized egg won't typically grow into an adult human. A fertilized egg will typically grow into an adult human.

>At some point in the distant past, our ancestors were non-human (and, possibly but not necessarily at the same time, not persons). The logical conclusion from your axiom is that there was, at some point, a hard boundary where an entirely nonperson animal gave birth to a "full person" human (and that first human then presumably had to reproduce through bestiality, unless through some amazing fortune another full 100% human being was born and fertile during their fertile years).

That's a good point. One thing though is that our actions today can't impact people in the past. So from an ethics point of view, we don't need to worry about the past, only the present and future. And as you say, we don't 100% know what happened in the past.

With the partial people view, someone might conclude today a person with a certain genetic disorder is similar to an ape, and thus a partial person, and thus doesn't need rights. By saying "no partial people today", we avoid that problem.

>If you believe that it is, your opinion is consistent. If it's not, then you must at least permit abortion in the case of rape, even if the fetus is a person.

I would say the way to resolve this is by defining what is the standard care that each person deserves.

If someone needs an exotic treatment that costs $1B/day to survive each day, and a hospital has the treatment in stock, is the hospital obligated to provide it to someone who can't pay? I would say no. It's within the hospital's rights to not give the person the treatment, or cease treatment if already provided in previous days.

However, is it within the hospital's rights to cease providing the person food and water against the person's will? (Let's avoid the euthanasia discussion and say the person is fully responsive but is quadriplegic.) I would say no. Food and water are standard care, and cannot be denied.

Food and water are standard care. The $1B treatment isn't.

2 people being attached permanently for the purpose of blood processing of a failed kidney isn't standard care.

A mother's womb is standard care for a fetus.

(Another thing to consider is what direct action is taken. In a D&E abortion, the fetus is cut into pieces with a scissors, which is the cause of death. So in the specific case of a D&E abortion, there's a second clear difference from the blood treatment case, in that it's a direct physical attack on the fetus that kills the fetus. E.g. in the kidney failure case, would it be ok to cut the person into pieces with a chainsaw? No, even if the person already is going to die of kidney failure. Other types of abortion are not as direct though, so this argument can't be as clearly used to condemn all types of abortion.)

Re: Scientists may have found a way to eliminate chromosome linked to Down syndrome

#510

Earlier quoted context omitted.

My worry is that if infants are only partial people, then people might come up with arguments that it's ok to kill them in some situations. And it opens the door to start classifying other people as partial people (e.g. disabled people). Which is why I say there's no such thing as a partial people.

But that was precisely my point. We shouldn’t classify anyone as partial people, which means we need to draw an intelligently chosen line separating the two. Choosing fertilization as this point seems irrational to me, and the consequence of this irrational choice harms an enormous number of women.

My point is that there isn't any point that can be chosen except fertilization, due to the continuum of development.
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