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GLP-1 drugs: An economic disruptor? (2024)

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Re: GLP-1 drugs: An economic disruptor? (2024)

#501

Post by lm28469 »

cedws wrote: post #376
lm28469 wrote: post #277

Earlier quoted context omitted.

I have the same reasoning but the opposite conclusion, we should seriously reconsider our lifestyle choices, as a society, instead of just throwing a magic pill in the mix and closing our eyes on the fact that we're building a completely insane system in which humans are everything but thriving

Ok cool, let me know how you plan to do that.

I'm doing that at my scale, helping friends and family with willpower and nutrition. So far I helped a dozen of people get control over their life's, including my father in law who lost 40kg and basically cured his health issues in less than a year. He could have taken ozempic but instead of that we taught him about the important of meal timing, how macro nutrients work, the effet of insulin/ghrelin on appetite, calorie counting, the benefits of walking an hour a day, &c.

100% free and he doesn't have to rely on a magic pill now that he understands what's going on.

When people are educated and motivated you can bring them wherever you want. Nutrition has to fit in the greater picture, if you're obese and addicted to shit food you most likely have much bigger problems in life, usually fixing the root causes unlocks the rest.

Re: GLP-1 drugs: An economic disruptor? (2024)

#502

Post by relaxing »

Henchman21 wrote: post #291
no_wizard wrote: post #276

Earlier quoted context omitted.

I’m not going to lie all this sounds like heaven to me. I absolutely hate the way my appetite works. I have a genuine dysfunction with food. It goes back as far as I can remember. My cravings never stop, even after being satiated. It’s an endless cycle of weight gain then loss then gain as my willpower fluctuates for a variety of reasons. My insurance only recently started to cover these weight loss drugs, and I have…

I'm a few months into this drug as well, and I have to say, it doesn't offer control . What it offers is a lack of cravings & appetite . That is different, remarkably so. Control would mean I might still feel hungry. Ever. Or that I could decide to eat heavily at one meal, but I don't and as long as I take the drugs, I won't. That doesn't feel like control, it feels like I've had something removed. I guess it's a mat…

I don’t understand what’s missing. What was the joy?

For me, hunger is misery, and so is feeling over-full. I’d do anything to take that away (well, short of sacrificing my financial security to pay the market rate for the drug.)

Re: GLP-1 drugs: An economic disruptor? (2024)

#503

Post by appleorchard46 »

andbberger wrote: post #477
ascorbic wrote: post #468

Earlier quoted context omitted.

Japan and South Korea. Much of southern Europe. It depends how you define healthy, but most of Europe has obesity rates below 20%. And that's just if you're counting rich countries.

japan https://data.worldobesity.org/country/japan-105/#data_trends south korea https://data.worldobesity.org/country/south-korea-114/#data_... spain https://data.worldobesity.org/country/spain-199/#data_trends greece https://data.worldobesity.org/country/greece-80/#data_trends

The linked data for Greece shows an obesity rate of ~17%, less than half the US' ~42%.

https://data.worldobesity.org/country/united-states-227/#dat...

Re: GLP-1 drugs: An economic disruptor? (2024)

#504

Post by lm28469 »

crazygringo wrote: post #286
lm28469 wrote: post #284

Earlier quoted context omitted.

I guess it's a cultural thing, we always reduce American recipes sugar by 75% or so

I'm very curious what one of your cake recipes is! Because sugar also greatly affects the texture of cake -- it retains moisture, prevents gluten formation, incorporates air... reducing sugar by 75% is going to make for a very dry, tough, and dense cake. I can't even imagine how you're going to make a cake recipe work with 75% less sugar. And it's not an American thing -- it's not like European cakes are any differen…

In that specific case it was a cheese cake. But I've made made fruit cakes with virtually no added sugar, just fruits, and sometimes even that is quite sweet

I can't eat cakes from coffee shops &co because they taste waaaaay too sweet.

Re: GLP-1 drugs: An economic disruptor? (2024)

#505

Post by whamlastxmas »

ReptileMan wrote: post #472
KaiserPro wrote: post #73

I would point out that it isn't unforeseen, given that genz don't drink, go out or do drugs to anywhere near the extent that millennials did at the same age. ( https://www.statista.com/chart/30783/alcohol-consumption-by-... ) I would also gently point out the evidence for tempering alcohol only seems to be evident with people who have high BMI https://www.pulsetoday.co.uk/news/clinical-areas/mental-heal... So yes, it…

>I would point out that it isn't unforeseen, given that genz don't drink, go out or do drugs to anywhere near the extent that millennials did at the same age Kids these days

No dessert until you finish your bong hit, sweetie

Re: GLP-1 drugs: An economic disruptor? (2024)

#506

Post by relaxing »

mac-mc wrote: post #483
ragazzina wrote: post #274

Earlier quoted context omitted.

> But what happens when I eat less and lose weight is that I have trouble concentrating. The glucose my brain needs just isn't there. This is crazy, I have the completely opposite effect. On keto + calorie restriction I feel much more alert and sharp.

It's because people are different, sometimes on a genetic level. What works well for one person does not work well at all for another, like the parent commenter, I do not work well without carbs. Keto puts me in a low-energy, semi-depressed state, while eating +80% of my calories as starch led me to lose about 15lbs of fat and now I'm the lowest body fat % I've ever been in my adult and teen life and my HOMA-IR went…

Can you elaborate on the genetics part? What were the relevant SNPs?

Re: GLP-1 drugs: An economic disruptor? (2024)

#507

Post by mhb »

GZGavinZhao wrote: post #122
mhb wrote: post #85

Earlier quoted context omitted.

How would you feel if you were born with an unusual and detrimental somatic condition that could be fixed with medicine?

Updated, I should clarify that assuming no medical needs.

It's a philosophical argument. There's a great Radiolab about this (if you can tolerate their banter). Man is acting weird and offensive. People treat him as you'd expect. Then it is discovered that he has a tumor that is causing his behavior. Now he receives sympathy and treatment.

The point being that we all have different brain configurations which cause our behavior. Some we call tumors. Others are "normal". Your definition of "medical needs" is where the interesting meta-discussion takes place.

Re: GLP-1 drugs: An economic disruptor? (2024)

#508

Post by akutlay »

toomuchtodo wrote: post #368
atomicnumber3 wrote: post #366

Earlier quoted context omitted.

Suppose a country had very low rates of depression, and another had very high rates. Is that just brain chemistry? Or does maybe one country have problems that cause many people to have depression? Or to push subclinical tendencies into clinical territory? The US is that but for obesity. Yes, absolutely some individuals have brain chemistry that predisposes them to this. But also maybe it's related to the cheapest an…

https://data.worldobesity.org/rankings/ https://www.who.int/activities/controlling-the-global-obesit... The US isn’t even the top 9. Obesity is a global epidemic of Western disease. The food isn’t the cause, it’s the symptom of the brain chemistry. If it isn’t available, yes, the disease may not present. But if available, due to hormones causing the drive , it presents. Like cigarettes (nicotine), like cocaine, like…

All the countries above US have less than 1M population and generally poor countries. Saying that obesity is not related to the underlying social problems in the US showing this data is ridiculous.

Re: GLP-1 drugs: An economic disruptor? (2024)

#509

Post by ben_w »

homebrewer wrote: post #326
TeMPOraL wrote: post #138

Earlier quoted context omitted.

> People who don't need to be chronically medicated should not be. If they're like typical westerners, they already self-medicate with coffee every day, with alcohol occasionally, and a big fraction of them (though much less than couple decades ago) also treat themselves with tobacco smoke - and ironically, weight loss is one of the few benefits some people actually use to defend their smoking. Do they need all that…

That "medication" has been used for millenia and its side effects are well understood by now. Not so much with these relatively new drugs.

The consequences of tobacco are so well known and so negative that they are legally mandated to be graphically depicted on every cigarette packet around here, and the main reason they are not banned is the observed impossibility that undid Prohibition in the USA.

So, sure, we don't know the long term risks of semaglutide ("just" 30 years or so) — but I say let people try it if they want, we let them use things we explicitly know to be dangerous, so why should we stand in the way of something that only might be eventually?

Re: GLP-1 drugs: An economic disruptor? (2024)

#510

Post by abirch »

cyberax wrote: post #355
abirch wrote: post #293

Earlier quoted context omitted.

gastroparesis is a real side effect two, it’s where the food in your digestive tract stops moving. As in 30% of food is present after 4 hours The rate is over 1% which isn’t a lot nor is it nothing https://jamanetwork.com/journals/jama/fullarticle/2810542

It looks like it's mostly caused by having too high doses of GLP-1 too soon.

I’m not about the root cause. I’m on a GLP-1 and while doing a premortem on my medication I saw that this, vomiting, and burps were common.
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