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Cinnamon can reverse changes in the brains of mice with Parkinsons

rush.edu

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Re: Cinnamon can reverse changes in the brains of mice with Parkinsons

#52

It's sort of gimmicky to say that Cinnamon does this, because it's known to be sodium benzoate that causes this effect. In 2012 they discovered that sodium benzoate has an effect on Parkinson's disease proteins: http://www.ncbi.nlm.nih.gov/pubmed/21701815 . This new study is, at least, a confirmation of the older study, and is also an attempt to use it to treat the disease.

weelllll the effect is supported in mice; likely after absorption. that is, starting with sodium benzoate may not survive the digestion process sufficiently before arrival at the target tissue (possibly the substantia nigra)

besides: cinnamon rolls! (with the more cinnamon the better)

Re: Cinnamon can reverse changes in the brains of mice with Parkinsons

#55
post #48
post #32

Earlier quoted context omitted.

Nicotine is sort of a mixed bag, but it isn't really the bad part of tobacco products. Cigarettes are generally bad for you because of all of the other things in them besides nicotine. The bad part of nicotine is that it is so highly addictive, but it's health benefits for things like ulcerative colitis and other afflictions are becoming better studied.

Radioactive polonium is the really worry with tobacco use.

Not sure why I was downvoted, look here: http://en.m.wikipedia.org/wiki/Polonium#Tobacco

Edit: I stand corrected. Thank you

Re: Cinnamon can reverse changes in the brains of mice with Parkinsons

#56
post #55
post #48

Earlier quoted context omitted.

Radioactive polonium is the really worry with tobacco use.

Not sure why I was downvoted, look here: http://en.m.wikipedia.org/wiki/Polonium#Tobacco Edit: I stand corrected. Thank you

Compare the 12,000 at the Wikipedia link to the 1.6 million here:

http://www.who.int/cancer/prevention/en/

From those numbers, the polonium is not a primary concern.

Re: Cinnamon can reverse changes in the brains of mice with Parkinsons

#57
post #20

It's sort of gimmicky to say that Cinnamon does this, because it's known to be sodium benzoate that causes this effect. In 2012 they discovered that sodium benzoate has an effect on Parkinson's disease proteins: http://www.ncbi.nlm.nih.gov/pubmed/21701815 . This new study is, at least, a confirmation of the older study, and is also an attempt to use it to treat the disease.

I don't think it's gimmicky. Cinnamon is cheap and easy to make and easy to deliver to the patient. Those practical implications are lost if it's only referred to as sodium benzoate. I don't know if this research is done with the same grants as the MS/Cinnamon study from the NIH, but it sounds like it: http://www.rush.edu/webapps/MEDREL/servlet/NewsRelease?id=15...

and i can put cinnamon on my oatmeal but sodium benzoate sounds disgusting

Re: Cinnamon can reverse changes in the brains of mice with Parkinsons

#58
post #30
post #27

Earlier quoted context omitted.

I doubt that cinnamon is cheaper than sodium benzoate.

Hey, we can use actually data for this! http://www.alibaba.com/showroom/price-of-sodium-benzoate.htm... http://www.alibaba.com/showroom/cinnamon-price.html Looks like the prices are surprisingly similar, though cinnamon is, if anything, more expensive. Additionally, I'd imagine that if sodium benzoate is the active ingredient, you'd need less of it to get the job done.

I'm not sure if you can assume this. I'm not sure myself, but the path that sodium benzoate finds its way into the bloodstream (or wherever it needs to be) is a bit more complicated than just "eat this pure sodium benzoate".

Apparently, cinnamon can be used as a vehicle for moving sodium benzoate to wherever it needs to be.

Re: Cinnamon can reverse changes in the brains of mice with Parkinsons

#59
post #55
post #48

Earlier quoted context omitted.

Radioactive polonium is the really worry with tobacco use.

Not sure why I was downvoted, look here: http://en.m.wikipedia.org/wiki/Polonium#Tobacco Edit: I stand corrected. Thank you

It's not entirely true. Even though the vast majority of tobacco-related cancer deaths may be caused by polonium, cancer deaths are still only around a third (iirc) of total tobacco deaths.

Re: Cinnamon can reverse changes in the brains of mice with Parkinsons

#60
Because it's clear there isn't a lot of expertise in this thread, I'd like to make clear that nobody should be doing the cinnamon challenge based on these results, or the results of the authors' previous study on the topic. So far, the authors have some interesting data from cell lines and now a mouse model of PD. Specifically, the mouse model is generated by chemical intoxication with a molecule called MPTP, which results in damage to dopaminergic cells in the substantia nigra, the region of the brain whose degeneration is predominantly implicated in the etiology of PD. There is good reason to be skeptical about whether this animal model of the disease is clinically relevant to sporadic PD seen in patients. Furthermore, dramatic results seen in a very obscure journal (i.e. not a mainline journal for neurodegenerative research) should generally result in knee-jerk skepticism until others repeat the work and a more significant review process has taken place. It should go without saying that there have been many compounds in the past two decades to show some interesting results at a preclinical stage that have not passed muster when moving to real patients.
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