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A first look at my microbiome
51–60 of 71 posts
Re: A first look at my microbiome
#52The difference is well within the variation you'd expect from multiple samples, extraction, PCR, sequencing, day-to-day. Also, you're probably better off trying to alter your gut microbiome through ingestion of probiotics. Source: I am a PhD student research the human gut microbiome in connection with autoimmunity and have processed thousands of these samples using the exact same methodology as uBiome.
Do we know specific pro-biotic species that have been found to be significantly more beneficial than the rest? How do we know? Does "pro-biotic" refer only to beneficial prokaryotic organisms or are there known beneficial "pro-biotic" foreign eukaryotes?
Lots of correlations and associations but no Koch's Postulate as far as I know.
Re: A first look at my microbiome
#53Hacker news: where your DIY at home poop transplant only upsets people because of an incorrect claim of statistical significance.
Re: A first look at my microbiome
#54Ok in the interest of harm reduction and informed consent, please please read the following two links if you are thinking about undergoing FMT:
http://thepowerofpoop.com/epatients/fecal-transplant-faqs/
http://thepowerofpoop.com/epatients/is-fecal-transplant-for-...
The biggest medical risk of the procedure involves contracting an illness from your donor, so it is paramount that you properly screen your donor with appropriate tests. (I really, really hope OP did this; otherwise he might have put himself in substantial risk.)
Also note that the effectiveness of FMT for autoimmune disorders has so far been anecdotal and not nearly as robust as for C. difficile infection and, to a lesser extent, IBD/Crohn's disease. Be very aware of the risks and the conjectural/unclear nature of the claimed benefits. As of now clinics in the US only administer the procedure except for C. difficile infection, which is why some patients have resorted to at-home DIY transplantation. Please see the links above for specific guidelines on how to follow the procedure safely, should you decide to proceed.
Also as other posters have repeatedly pointed, the microbiome changes you report are well within variation/assay error and perhaps not as informative as you might expect.
Re: A first look at my microbiome
#55This is probably an unpopular opinion but it seems to me that "SV culture" has taken to fetishizing "health hacking" with little to no medical training/background or support. See the recent SV craze with "health informatics hacking". They're putting a shiny, appealing veneer over what amounts to homeopathy and random self-experimentation. Someone is going to say, "but they have all this data, like this guy from µBiom…
OP: I'm not from uBiome. I'm a uBiome customer. I've had little interaction with the uBiome staff to date.
Re: A first look at my microbiome
#56Earlier quoted context omitted.
OP: Thanks, removed the word "significant". I can't make any claims about the results yet. The donor sample is coming in soon so I will be able to make that comparison.
You need to know standard deviations: the standard error of the measuring device (from Biome), the standard deviation within a subject (i.e. between measurements on different places, different times in one person) and between subjects. Until you know those, you will be unable to conclude anything from these numbers.
I pulled all the language that attempted to draw conclusions. I had removed the entire article but I received several emails from people who weren't interested in my results, just wanted to know what I did.
Re: A first look at my microbiome
#57OP: Sorry all. I had hoped to raise awareness and encourage discussion, but I think there's a bigger danger that the way I presented this "experiment" will do more harm than good for the perception of FMT and at home microbiome exploration. I will consider revisiting once I've got my ducks in a row.
After receiving several emails protesting the removal of the article, I reposted it after editing out the parts that attempted to draw conclusions. There's also a disclaimer at the top that warns about the danger of FMT.
Re: A first look at my microbiome
#58I'm going to create a Kickstarter to sell shit. Pledge $5 or more: FMT Hall of Fame Receive a used wipe, suitable for bragging or framing (plus S&H). Pledge $100 or more: [EARLY BIRD] DIY kit: You'll get everything needed for a basic FMT, PLUS a single type 1 Bristol stool from one of our lead engineers.(plus S&H) Pledge $500 or more: FMT Classroom Educational Package Join us for a PRIVATE squatting ceremony at a loc…
I'm so proud of my university.
Re: A first look at my microbiome
#59Goodness me. I have seen it all now. I do hope peer-to-peer poo sharing finds its way into an episode of that new HBO Silicon Valley series.
Re: A first look at my microbiome
#60So basically he took another persons feces and put it in himself. Cause he had read about it in a completely different context. and it had almost no effect.