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The first early human eggs from stem cells

conception.bio

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Re: The first early human eggs from stem cells

#51

Post by wossab »

DanielHB wrote: post #45
londons_explore wrote: post #20

I am worried about the long term impact of research involving human conception, IVF, etc. The reason is that genetics/evolution don't yet seem to fully explain how humans exist. A computer genetic algorithm run for a billion generations doesn't lead to anything anywhere near the the complexity of a human. I suspect there are as-yet undiscovered effects which shape the next generation. Whether that be DNA methylation,…

25% of humans died before reaching 5 in 1800s US, today it is We have not ended up with "humans which aren't as strong, aren't as smart, aren't as well adapted to a changing environment, etc."

How would you know?

Re: The first early human eggs from stem cells

#53

Post by qsera »

DanielHB wrote: post #45
londons_explore wrote: post #20

I am worried about the long term impact of research involving human conception, IVF, etc. The reason is that genetics/evolution don't yet seem to fully explain how humans exist. A computer genetic algorithm run for a billion generations doesn't lead to anything anywhere near the the complexity of a human. I suspect there are as-yet undiscovered effects which shape the next generation. Whether that be DNA methylation,…

25% of humans died before reaching 5 in 1800s US, today it is We have not ended up with "humans which aren't as strong, aren't as smart, aren't as well adapted to a changing environment, etc."

> We have not ended up with "humans which aren't as strong, aren't as smart, aren't as well adapted to a changing environment, etc."

Haven't we?

Re: The first early human eggs from stem cells

#54

Post by killerstorm »

londons_explore wrote: post #20

I am worried about the long term impact of research involving human conception, IVF, etc. The reason is that genetics/evolution don't yet seem to fully explain how humans exist. A computer genetic algorithm run for a billion generations doesn't lead to anything anywhere near the the complexity of a human. I suspect there are as-yet undiscovered effects which shape the next generation. Whether that be DNA methylation,…

> A computer genetic algorithm run for a billion generations doesn't lead to anything anywhere near the the complexity of a human.

What?... Our computers can't simulate anything similar to a real world. You're comparing apples to galaxies.

> meaningful loss of fitness

What makes you think we don't have "loss of fitness" already?

150 years ago child mortality was around 30% in the developed world, now it's less than 1%. A lot of kids with weak health survive now. I'm one of them - I got pneumonia when I was ~2 y.o. and probably would have died without antibiotics. Then I had something which required antibiotic treatment pretty much every year. My wife also had a pneumonia in early childhood. And so did my daughter...

Why do we need to talk about some mysterious problem in 10 generations when modern medicine removes a lot of fitness pressure by itself?

Re: The first early human eggs from stem cells

#55

Post by krageon »

wossab wrote: post #51
DanielHB wrote: post #45

Earlier quoted context omitted.

25% of humans died before reaching 5 in 1800s US, today it is We have not ended up with "humans which aren't as strong, aren't as smart, aren't as well adapted to a changing environment, etc."

How would you know?

When you make an outrageous claim the burden of proof is on the claimant. Given that there isn't a real indication of anything to the contrary, it is reasonable to assume reality is still the way it always was and humans are too.

Re: The first early human eggs from stem cells

#56

Post by qsera »

Arodex wrote: post #34
londons_explore wrote: post #20

I am worried about the long term impact of research involving human conception, IVF, etc. The reason is that genetics/evolution don't yet seem to fully explain how humans exist. A computer genetic algorithm run for a billion generations doesn't lead to anything anywhere near the the complexity of a human. I suspect there are as-yet undiscovered effects which shape the next generation. Whether that be DNA methylation,…

>The reason is that genetics/evolution don't yet seem to fully explain how humans exist. A computer genetic algorithm run for a billion generations doesn't lead to anything anywhere near the the complexity of a human. I didn't have "creationism" as the top answer to a HN post in 2026, yet here we are...

How is that creationism? Saying that we don't have a good answer is not the same as suggestion one particular hypothesis.

To me suggesting that sounds pretty anti-intellectual!

Re: The first early human eggs from stem cells

#57

Post by dryarzeg »

Arodex wrote: post #34
londons_explore wrote: post #20

I am worried about the long term impact of research involving human conception, IVF, etc. The reason is that genetics/evolution don't yet seem to fully explain how humans exist. A computer genetic algorithm run for a billion generations doesn't lead to anything anywhere near the the complexity of a human. I suspect there are as-yet undiscovered effects which shape the next generation. Whether that be DNA methylation,…

>The reason is that genetics/evolution don't yet seem to fully explain how humans exist. A computer genetic algorithm run for a billion generations doesn't lead to anything anywhere near the the complexity of a human. I didn't have "creationism" as the top answer to a HN post in 2026, yet here we are...

Have you read the next paragraph?

> I suspect there are as-yet undiscovered effects which shape the next generation. Whether that be DNA methylation, gut bacteria passing from mother to child, selection of the 'correct' egg or sperm out of millions, or something new and un-discovered etc.

I can't see where it mentions "creationism".

Re: The first early human eggs from stem cells

#58

Post by Mistletoe »

DanielHB wrote: post #45
londons_explore wrote: post #20

I am worried about the long term impact of research involving human conception, IVF, etc. The reason is that genetics/evolution don't yet seem to fully explain how humans exist. A computer genetic algorithm run for a billion generations doesn't lead to anything anywhere near the the complexity of a human. I suspect there are as-yet undiscovered effects which shape the next generation. Whether that be DNA methylation,…

25% of humans died before reaching 5 in 1800s US, today it is We have not ended up with "humans which aren't as strong, aren't as smart, aren't as well adapted to a changing environment, etc."

I like the spirit of what you are saying but the smart part isn’t true at all. IQ peaked around the mid 1990s and as someone that lived back then that tracks.

https://www.sciencedirect.com/science/article/pii/S016028962...

Look at Fig. 3. The world seems to be experiencing a reverse Flynn effect.

Re: The first early human eggs from stem cells

#59

Post by XorNot »

londons_explore wrote: post #20

I am worried about the long term impact of research involving human conception, IVF, etc. The reason is that genetics/evolution don't yet seem to fully explain how humans exist. A computer genetic algorithm run for a billion generations doesn't lead to anything anywhere near the the complexity of a human. I suspect there are as-yet undiscovered effects which shape the next generation. Whether that be DNA methylation,…

That's a lot of words to act like a total tool towards people born from IVF and their parents.

Re: The first early human eggs from stem cells

#60

Post by pelagicAustral »

saturn8601 wrote: post #44
londons_explore wrote: post #20

I am worried about the long term impact of research involving human conception, IVF, etc. The reason is that genetics/evolution don't yet seem to fully explain how humans exist. A computer genetic algorithm run for a billion generations doesn't lead to anything anywhere near the the complexity of a human. I suspect there are as-yet undiscovered effects which shape the next generation. Whether that be DNA methylation,…

Very interesting...maybe this is another great filter preventing a species from becoming multi planetary or expanding beyond a type 0 civilization?

I would've thought that generic engineering was the biggest ticket to getting a civilization out of their home planet...
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