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Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

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Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#51

Post by riskassessment »

jcranmer wrote: post #41
nikkwong wrote: post #30

Earlier quoted context omitted.

That's not true. Monoclonal antibodies are on the market right now which slow the progression of the disease (by removing amyloid).

AIUI, all such results are because the FDA has given up since aduhelm and said "well, if it clears amyloid, that's as good as slowing Alzheimer's, right?" despite the actual results on Alzheimer's progression being largely negative.

For what it's worth, early statins were originally cleared based only on the evidence that they lower cholesterol without longer term studies showing a reduction in mortality. Of course there is now plenty of evidence showing statins improve overall endpoints.

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#54

Post by laserdancepony »

Spivak wrote: post #50
lithocarpus wrote: post #43

Earlier quoted context omitted.

If the doses of cannabis required to cure alzheimers would be high enough doses to destroy the rest of one's brain, it makes this finding not very useful, similar to the idea of curing alzheimers by destroying one's brain/

Synthetic cannaboids were also studied as a possible analgesic and at the doses required it caused brain damage. Which is honestly disappointing because a general purpose pain killer that isn't opioid based would be a miracle.

We have dozens of pain killers which are not opioid based, what do you mean? From the top of my head NSAIDs can be used, and Metamizole for example is as effective as morphium.

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#55

Post by DANmode »

Loughla wrote: post #14
dmorgan81 wrote: post #11

Earlier quoted context omitted.

Have you tried L-theanine? I also get panic attacks with weed, but L-theanine seems to help keep them at bay.

I've tried everything and I still get panic attacks. I used to love smoking a small hitter about an hour before bed. I've always had insomnia and that was the one thing that actually helped me sleep. When it was illegal, I loved it. I would smoke 2 or 3 times a week just for sleep, and I was healthy and happy. . . Because sleep is important, and I never wanted to take sleeping pills because dependency. Now that it's…

How low was the % of THC in the Charlotte’s Web?

Full spectrum hemp (~0%) definitely feels like the answer, here!

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#57

Post by Muvasa »

laserdancepony wrote: post #54
Spivak wrote: post #50

Earlier quoted context omitted.

Synthetic cannaboids were also studied as a possible analgesic and at the doses required it caused brain damage. Which is honestly disappointing because a general purpose pain killer that isn't opioid based would be a miracle.

We have dozens of pain killers which are not opioid based, what do you mean? From the top of my head NSAIDs can be used, and Metamizole for example is as effective as morphium.

you got nsaids, metamizole, acetoaminophen, duolexitine. And you got a couple of more that work for neuropathic pain. The biggest problem with nsaids is that they cause bleeding and kidney failure, ulcers hence can cause stomach cancer.

Here is a site you can use too see how most pharmaco therapy is lacking.

https://pain-calculator.com/calculators/osteoarthritis-pain/

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#58

Post by Muvasa »

nikkwong wrote: post #30
jcranmer wrote: post #26

Too bad we've had like a half-dozen putative Alzheimer's drugs that clear amyloid beta that turn out to do nothing to slow or prevent Alzheimer's. Actually, I think even by 2016 we already had enough phase 3 drug failures that the amyloid hypothesis was severely called into question?

That's not true. Monoclonal antibodies are on the market right now which slow the progression of the disease (by removing amyloid).

~~yes by 4 months. If I had AD i wouldn't bother with those treatments.~~ Sorry I missed the context you are right the fact that they slow AD by 4 months is a proof that amyloid plaques are part of the pathogenesis.

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#59

Post by hermanzegerman »

laserdancepony wrote: post #54
Spivak wrote: post #50

Earlier quoted context omitted.

Synthetic cannaboids were also studied as a possible analgesic and at the doses required it caused brain damage. Which is honestly disappointing because a general purpose pain killer that isn't opioid based would be a miracle.

We have dozens of pain killers which are not opioid based, what do you mean? From the top of my head NSAIDs can be used, and Metamizole for example is as effective as morphium.

Metamizol is banned in the US, so they've robbed themselves of that

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)

#60

Post by SeanAnderson »

farmdawgnation wrote: post #42
mrosett wrote: post #27

Earlier quoted context omitted.

Reminds me of this classic: https://xkcd.com/1217/

There may not be many constants in this life, especially in this day and age, but I do find it humbling that "there is always an xkcd for that" holds true.

...is there an XKCD relevant to the fact there's always a relevant XKCD?
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