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Enhancing gut-brain communication reversed cognitive decline in aging mice

med.stanford.edu

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Re: Enhancing gut-brain communication reversed cognitive decline in aging mice

#51

Post by throwawaytea »

y-curious wrote: post #30
zinkem wrote: post #28

Earlier quoted context omitted.

I believe this research is totally true-- I had a lot of memories come back after 1. I stopped drinking heavily and using other drugs, i.e. marijuana 2. managed my diet to avoid heartburn without medication 3. schedule my meals so it was easier to sleep at night (always eat something for breakfast when I wake up) I did not need any "poo infusion" or anything. I had a gal bladder removal that didn't fix the problems t…

What did you do for heartburn? Just looking for ideas. I noticed reducing gluten helped me personally a lot

Im not saying to live this way, but a super restrictive test diet may open your eyes to some thing and then you can add back.

I even once read that someone noticed an issue they tried to clear up for years with doctors went away on day 3 of a water fast. No, he wasn't going to fast forever. But he was shocked the first relief he ever had was that day. From there he solved his problem once his eyes were opened a bit.

I'd personally try all ground beef for a week or two. It won't kill you. Is it ideal? Probably not. But you will not have any problems from that short trial. Then add things slowly until you have a whole good diet you like.

Re: Enhancing gut-brain communication reversed cognitive decline in aging mice

#53

Post by ratg13 »

y-curious wrote: post #30
zinkem wrote: post #28

Earlier quoted context omitted.

I believe this research is totally true-- I had a lot of memories come back after 1. I stopped drinking heavily and using other drugs, i.e. marijuana 2. managed my diet to avoid heartburn without medication 3. schedule my meals so it was easier to sleep at night (always eat something for breakfast when I wake up) I did not need any "poo infusion" or anything. I had a gal bladder removal that didn't fix the problems t…

What did you do for heartburn? Just looking for ideas. I noticed reducing gluten helped me personally a lot

It might not be gluten (protein) that is affecting you, but the fructans (carbohydrates) that are found in wheat, rye, and barely which are high in FODMAPs.

Look into low-FODMAP diets if you haven't already.

Re: Enhancing gut-brain communication reversed cognitive decline in aging mice

#54

Post by BizarroLand »

esperent wrote: post #49
slibhb wrote: post #46

Earlier quoted context omitted.

In my opinion, gut microbiome stuff is massively overhyped. Here's a study that tried fecal transplants to treat mental illness (and found no effect): https://pubmed.ncbi.nlm.nih.gov/41785480/ The pattern with this stuff is that, when a blinded study is carried out, there's usually no effect.

Here's a meta analysis of 12 studies showing that FMT has a significant effect in reducing depression: https://pmc.ncbi.nlm.nih.gov/articles/PMC12536323/ It also found the effect was greater in people with IBS.

I wonder how that study would fare against a double blind where some people get FMT and others do not, but they are both given the same attention and care otherwise over the course of the study?

Re: Enhancing gut-brain communication reversed cognitive decline in aging mice

#55

Post by BizarroLand »

theusus wrote: post #7

Mice mice mice. Tell me when you test on humans

In theory you would never test on humans directly. You would go through various order testing and slowly work your way up to a final verification on human subjects that has almost no chance of going wrong and that the worst possible outcome is that nothing happens.

Re: Enhancing gut-brain communication reversed cognitive decline in aging mice

#56

Post by ratg13 »

y-curious wrote: post #32
hbcondo714 wrote: post #10

Earlier quoted context omitted.

I would recommend the site https://gutbrainaxistherapeutics.com for learning more about Microbiota Transplant Therapy (MTT) and its opportunities, especially for Autism and Pitt-Hopkins Syndrome.

I’ll dig in more but my first question when I see this: who are the donors exactly? Like who decides what the ideal gut microbiome is and that John Doe is the guy to provide his fecal matter to the masses?

You either need a lab to test donor samples first, or when this was more of a craze, a popular source of 'donations' for the DIY crowd was young children.

If you're interested in digging into the people that were doing this, they had a website dedicated to everyone telling their stories of how they went about their own individual journeys.

The website was called thepowerofpoop.com and looks like it's gone now, but is available on the wayback machine including individual articles and images.

I would go back to at least 2022 .. I think they possibly got in legal trouble at some point and started taking things down.

Re: Enhancing gut-brain communication reversed cognitive decline in aging mice

#58

Post by mustaphah »

jrapdx3 wrote: post #38
mustaphah wrote: post #14

Yeah, it's a mouse study, but there are tons of human studies backing the whole gut-brain connection. There are even a bunch of books on it [1][2]. What's really cool is that the paper used low-dose capsaicin (just 5 μg/kg injected), and it completely restored hippocampal FOS activity and memory in older mice. Basically, that's the same stuff you get in cayenne pepper supplements - pretty easy to get your hands on. […

I've long regarded the great variety of chilis as its own distinct food group. But wonderful as they are for flavoring food, quite often in my home, I'm not sure how much of an effect orally consumed capsaicin has on memory functioning. Conceivably parenteral capsaicin has different effects on hippocampal integrity or physiology than achievable with ingestion. I'm not familiar enough with disposition of capsaicin in…

Chili could work [1], but not too much of it [2]

[1] https://pubmed.ncbi.nlm.nih.gov/27079706/

[2] https://pubmed.ncbi.nlm.nih.gov/31137805/

Re: Enhancing gut-brain communication reversed cognitive decline in aging mice

#59

Post by throwawaytwit9 »

y-curious wrote: post #30
zinkem wrote: post #28

Earlier quoted context omitted.

I believe this research is totally true-- I had a lot of memories come back after 1. I stopped drinking heavily and using other drugs, i.e. marijuana 2. managed my diet to avoid heartburn without medication 3. schedule my meals so it was easier to sleep at night (always eat something for breakfast when I wake up) I did not need any "poo infusion" or anything. I had a gal bladder removal that didn't fix the problems t…

What did you do for heartburn? Just looking for ideas. I noticed reducing gluten helped me personally a lot

It may not work for you but I had years of chronic heartburn. While sick with covid in 2020, I stopped consuming coffee and alcohol. It took a few months and for the long covid symptoms to subside, and then no more heartburn. At all. I felt really dumb that I never connected it to coffee before. I didn’t experience direct symptoms from coffee and I didn’t consume an excess amount. But it definitely was the cause.

Re: Enhancing gut-brain communication reversed cognitive decline in aging mice

#60

Post by bitexploder »

inanutshellus wrote: post #9

Everyone's "poo-pooing" the article because the title doesn't mention mice, but, FWIW, stories of gut biota affecting humans behavior have been documented for a while. Memory gain is noteworthy, which is the article's "wow" factor, but everyone's just knee-jerk smirking so ... here's a few random articles to gross you out about the wild world of trading microbiota and, for better or worse, changing your personality:…

Most of the serotonin we produce comes from our gut.
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