Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Hungry Fat Cells Could Someday Starve Cancer

ucsf.edu

Post reply on HN
Print view View original

51–57 of 57 posts

Re: Hungry Fat Cells Could Someday Starve Cancer

#51

Post by Fire-Dragon-DoL »

_yb2s wrote: post #46
Fire-Dragon-DoL wrote: post #31

Earlier quoted context omitted.

I cannot work when I don't eat, I'm unable to think properly. I'm not sure how people manage fasting

People respond differently to fasting, some are never able to do focused knowledge work during a fast, others can’t at first but can once their bodies get used to fasting. Others can immediately focus better right from the beginning. There is a lot of individual variation.

I literally cannot sleep if hungry. I wake up in the middle of the night if I had dinner and went to bed at midnight. My trick is to eat one apple right before sleep, then I wake up not hungry and can sleep well.

Re: Hungry Fat Cells Could Someday Starve Cancer

#52

Post by [deleted] »

Fire-Dragon-DoL wrote: post #35
sowbug wrote: post #34

Earlier quoted context omitted.

If you can handle the body's switchover to ketosis, the rest of the fast is relatively easy.

I did that before, my breath becomes horrible when that happens, but it's way more manageable. Is there a way to activate ketosis before starting the fasting? That seems like it could solve my problem

[deleted]

Re: Hungry Fat Cells Could Someday Starve Cancer

#53

Post by dustbunny »

_yb2s wrote: post #45
dustbunny wrote: post #29

Earlier quoted context omitted.

How do you create/store the ice?

I have an inflatable ice tub from costco, and a large aquarium chiller. There is no literal ice involved, just a tub of water that is just above freezing temps. You can buy regular bags of ice and put them in a bathtub full of water, but that is a hassle and expensive to do frequently.

So do you keep it chilled 24/7 or do you turn it on manually or with a timer?

Re: Hungry Fat Cells Could Someday Starve Cancer

#54

Post by _yb2s »

dustbunny wrote: post #53
_yb2s wrote: post #45

Earlier quoted context omitted.

I have an inflatable ice tub from costco, and a large aquarium chiller. There is no literal ice involved, just a tub of water that is just above freezing temps. You can buy regular bags of ice and put them in a bathtub full of water, but that is a hassle and expensive to do frequently.

So do you keep it chilled 24/7 or do you turn it on manually or with a timer?

Timer

Re: Hungry Fat Cells Could Someday Starve Cancer

#55

Post by mettamage »

manmal wrote: post #40
mettamage wrote: post #30

For the curious among us, here are articles related to cold exposure in mice and cancer [1, 2, 3]. I briefly skimmed it but seems like a somewhat plausible idea in the realm of: if it doesn’t hurt you, it can perhaps benefit you. Also, I think in some cases you can pair it with the Wim Hof Method to make short extreme cold exposure more bearable. I don’t know what the interaction is with norepinephrine though as doin…

Why would someone do this to themselves? Such a trip doesn’t sound like a lot of fun. Wouldn’t long term sauna have similar effects and be way less straining on the cardiovascular system?

Don't know, haven't looked into it. Do you have any sources I could start reading on?

Re: Hungry Fat Cells Could Someday Starve Cancer

#56

Post by rajnathani »

__natty__ wrote: post #17
sejje wrote: post #2

> Nguyen moved to UT Austin to start his own lab in January 2024 but passed away suddenly in November before he could finish the final experiments. The paper, of which he is the first author, is dedicated to him. That's sad. I hope someone picks up the torch. The research sounds very promising.

And he was only 35. Rest in peace.

Really interesting research. Rest in peace. An aside: The cause of death was a stroke: https://nutrition.utexas.edu/about-us/memoriam

Re: Hungry Fat Cells Could Someday Starve Cancer

#57

Post by sowbug »

_yb2s wrote: post #49
sowbug wrote: post #36

Earlier quoted context omitted.

Ketosis is your body using fat as an energy source when glucose isn't readily available. So if you deprive yourself of dietary glucose (carbs, simple sugars, etc), but keep eating fat and protein, you'll enter ketosis while eating as much sustenance as you want. Use ketone strips to tell when it happens. The breath thing is unavoidable as far as I know.

Apologies in advance for the pedantic response, but the human body can generally make enough glucose from protein to keep you out of ketosis. You usually have to restrict both protein and fat to reliably induce ketosis. You can confirm this for yourself with ketone test strips. Most dieters on so called ketogenic diets are not actually in ketosis. Even more surprising is that fermentable fibers get converted into sho…

I believe you but can't attest from personal experience. Almost any time I've gone low carb and into ketosis, I've also reduced my calorie intake. All you can eat bacon and eggs gets old quick.
Post reply on HN