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Pfizer ended up passing on my GLP-1 work back in the early '90s (2024)

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Re: Pfizer ended up passing on my GLP-1 work back in the early '90s (2024)

#51
post #31
post #14

Earlier quoted context omitted.

Isn't there some long term harm to the skin if you do this often?

Insulin users would have better answers to this question, since they might inject multiple times a day, whereas GLP-1 users typically inject only weekly. But in either case, the answer for subcutaneous injections using needles sized 29g and smaller is no.

I’ve been diabetic for 30 years, and for more than twenty of those I did multiple daily measurements by pricking my fingertips and multiple insulin injections per day. Now I wear a sensor that I replace every two weeks and a catheter (which I change about once a week).

I really don’t understand this phobia of needles at all. After two days with one system or the other, you get used to it—there’s no pain, it’s just a mental issue of “having to make the gesture.”

My friends used to laugh at how normal it was for me to inject insulin outside a restaurant, while walking, chatting, and smoking at the same time.

Re: Pfizer ended up passing on my GLP-1 work back in the early '90s (2024)

#52

This is subscriber-walled, but the full article is available here: https://web.archive.org/web/20240909093450/https://www.statn... The key reason Pfizer passed was that executives didn't think patients would accept a new therapy that required injection to administer: Despite our emerging results, the Pfizer executives in charge of research and external alliances told us the company did not want to develop a new diabe…

Pfizer has been resting on their laurels ever since it struck gold with boner pills and Lipitor. Viagra made it rain beaucoup bucks and rewired the entire firm to prioritize commercial sales and marketing over real scientific clinical development. Pfizer is optimized for sales over research and development. Now they primarily acquire and license a bunch of me-too drugs and late-stage acquisitions vs creating their own homegrown breakthroughs.

Pfizer's strengths are regulatory compliance, M&A and global manufacturing. They suck at research and clinical development. Losing the GLP-1 race was predictable as they simply don't prioritize emerging science compared to other mid-sized and large pharmas.

Re: Pfizer ended up passing on my GLP-1 work back in the early '90s (2024)

#53

Earlier quoted context omitted.

Wait -your angle is that covid vaccination increased people‘s acceptance of injectable pharmaceutics and covid / its vaccine was made up (or blown out of proportion) so people would get more ozempic?

No. Not my angle. That is exactly what happened. Injections are no longer a only-if-absolutely-necessary. The stigma is mitigated.

Flu shots were accepted as a routine thing long before 2020. I don't think the stigma existed in the way you're imagining.

Re: Pfizer ended up passing on my GLP-1 work back in the early '90s (2024)

#54

Earlier quoted context omitted.

No. Not my angle. That is exactly what happened. Injections are no longer a only-if-absolutely-necessary. The stigma is mitigated.

Flu shots were accepted as a routine thing long before 2020. I don't think the stigma existed in the way you're imagining.

Accepted? By who? You’ve misread the room
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