In general there is a lot of work on ultrasound stimulation now, some of it is scary in other ways: https://www.nature.com/articles/s41467-025-65080-9 which could imaginably lead to wireheading or something like Niven's "tasp".
Due to some family stuff, this is something I've been investigating. My oncologist has said "this will probably be standard care in a few years". The results and studies around this have been excellent. What this does better than pretty much anything else is it isolates the destruction of cells to just the target. The liver is a VERY "bleedy" organ. It has a ton of blood that flows through it which makes surgery extr…
Pretty pricey, yes. HistoSonics is a microcosm of the truth of healthcare spending: it is an amazing technology made by possible by deep and sophisticated capital markets. But, better health technology seems to explain more than 50% of the growth of healthcare spending since medicare (1965), meaning all of the faster-than-GDP growth people gripe about. When people talk about slowing health spending to something manageable, they are talking about not just govt not paying for things like histotrispy - not paying is a shell game, nobody chooses to not pay to save their life, and hence faster than GDP healthcare spending growth is observed everywhere in the West, not just the US. They are talking about somehow making the technology not happen altogether.
no symptoms. first identified the lesion a few years back and it hadn't changed over a few subsequent appointments. exam this year, it had grown a small amount 5mmx5mm to 6mmx8mm - still considered small, but the change was enough for the Drs to recommend treatment. I have been treated by Dr. Dan Gombos[1] at MD Anderson and received excellent care. [1] https://faculty.mdanderson.org/profiles/dan_gombos.html
Being non-invasive and incredibly precise, this could be a fantastic therapy for brain cancer treatment.
Assuming the costs of the precise powerful machines needed are not too high (this isn't anything like MRI), it could be a therapy for almost any kind of cancer tumor, and even small potential/pre-cancer tumors that are safe to remove without bothering to do a diagnosis.
What are the chances that breaking up a tumor this way seeds cancer elsewhere in the body? 2024 meta analysis of seeding I didn't see ultrasound in there: https://pubmed.ncbi.nlm.nih.gov/39605885/ Here is a study on AEs specifically from this type of ultrasound: https://journals.plos.org/plosone/article?id=10.1371/journal... Quote: "Cavitation detaches cancer cells/emboli from the primary site and thereby releases th…
Chemo post-histrophy would remove any lingering cancer cells effectively. Cancer cells need lots of fuel or they stop replicating, and this is what traditional chemo is great at stopping.
The keto diet is also very good for this because many (but not all) cancer cells can't metabolize ketones. However recent research from Columbia Medical School suggests that it can promote metastasis.
Due to some family stuff, this is something I've been investigating. My oncologist has said "this will probably be standard care in a few years". The results and studies around this have been excellent. What this does better than pretty much anything else is it isolates the destruction of cells to just the target. The liver is a VERY "bleedy" organ. It has a ton of blood that flows through it which makes surgery extr…
We simply won’t know until they do the inevitable phase2/3 RCTs. They will need to show that this method helps people survive longer or with better quality of life than the current standard of care.
HistoSonics has studies published with 50 patients. Their upcoming study with 5000 liver patients obviously will give more information, but we already have some. And with that said, these studies are more relevant than the top of thread linking to a review from 2011 looking at papers from 2005-2006 for ultrasound cavitation causing metastases.
...they also appear to have been acquired by an investment group this past year:
Due to some family stuff, this is something I've been investigating. My oncologist has said "this will probably be standard care in a few years". The results and studies around this have been excellent. What this does better than pretty much anything else is it isolates the destruction of cells to just the target. The liver is a VERY "bleedy" organ. It has a ton of blood that flows through it which makes surgery extr…
I'm unfortunately on the same situation. We made a consultation with people from Baptist Health Miami and it seems like there are several non trivial requirements for such treatment (histotripsy), like the number and location of mets. Hope that this improves in the mear future.