Earlier quoted context omitted.
Don't you just intercept traffic to well know recursive resolvers? And then drop packets to ports other than 53?
That's the beauty of DoH - you don't have to pick a resolver which uses a dedicated IP. You can even stand your own up behind a CDN and blocking it would mean blocking HTTPS traffic to the CDN.
If I really do need to get that last bit, there's always other analysis to be done (request/response size/cadence, always talks to host X before making connections to other hosts, etc)