The only caveat being this assumes all your data can fit on a single machine, and all your processing can fit on one machine. You can get a a u-24tb1.112xlarge with 448 vcores, 24TB RAM for 255/hour and attach 64TB of EBS -- that's a lot of runway.
> The only caveat being this assumes all your data can fit on a single machine Does my data fit in RAM? https://yourdatafitsinram.net/ Not sure using EC2/AWS/Amazon is a good example here, if you're squeezing for large single-node performance you most certainly go for dedicated servers, or at least avoid vCPUs like a plague.
So yeah, easily.