The Molecular Basis of Long Covid Brain Fog • Hacker News Board

Re: The Molecular Basis of Long Covid Brain Fog

#51

Post by Nevermark » Sun, Oct 12, 2025, 4:32 AM UTC

relaxing wrote: post #46

Aurornis wrote: post #19

Earlier quoted context omitted.

> It quite specifically doesn’t say “the basis” The headline quite specifically does say: "Uncovering the Molecular Basis of Long COVID Brain Fog" The article also implies that AMPA drugs could address COVID brain fog: > For example, drugs that suppress AMPAR activity could be a viable approach to mitigate brain fog. This was one of the points I was trying to counter. It also claims to have "resolved key uncertaintie…

It does not say “the basis.” It is concerning you don’t understand the discrepancy there. You are welcome to your opinion about what is key, but reading comprehension does not seem to be your strong suit.

> "Uncovering the Molecular Basis [...]"

> "the [...] Basis"

The adjective molecular doesn't narrow "the basis" down much, for a condition which could safely be assumed to be molecular.

Re: The Molecular Basis of Long Covid Brain Fog

#52

Post by devin » Wed, Oct 15, 2025, 4:49 PM UTC

leetrout wrote: post #13

MengerSponge wrote: post #3

There's so much we don't know about this yet. It's great to see new knowledge being generated! I had Covid last February (vaccinated and boosted, thankfully). It was a mild course, but I wound up sensitized to caffeine for three to four months after. I normally drink 100-150mg/day, but I had to cut that back to 50-60mg and only in the morning. It seems to have passed, so I'm back on my drip.

Thank you for sharing. I have the same thing and it is from my first bout with Covid in 2021. I have now had Covid 4 times and the caffeine sensitivity remains along with PVCs and chest pain. Brain fog has been almost debilitating and overall the impact on my career performance is noticeable.

Have you been getting the annual booster? There is no agenda or gotcha coming, I am genuinely just curious.

Re: The Molecular Basis of Long Covid Brain Fog

#53

Post by WalterSear » Fri, Oct 17, 2025, 2:02 AM UTC

Animats wrote: post #28

From the paper's abstract: "A partial least squares model trained on the index of AMPAR density data demonstrated high diagnostic accuracy, achieving 100% sensitivity and 91.2% specificity." That seems to mean there's a diagnostic test now.

There's been more than one way to reliably differentiate CFS patients from controls announced this year. However, there's no clinical diagnostic yet.