This is one of the reasons I like Ableton Live ( http://www.ableton.com/suite-8 ): it has a simple, consistent user interface elements and the entire user interface happens to be vector based. Not only is it easy to navigate and understand, but the fact that it is vector based allows it to have a resolution-independent interface that can be zoomed in/out. Which addresses another problem with music production software: they tend to use tiny fonts and other UI elements which makes it hard to read when used with a high-PPI monitor and/or when the monitor is far enough away from the user (which seems to often be case in many studio setups). And once you've done a highly graphical skeuomorphic interface that uses lots of bitmaps, scaling doesn't always happen smoothly.
On the other hand, many people like skeuomorphic interfaces when they've had past experience with actual audio hardware. Reason ( http://www.propellerheads.se/products/reason/ ) is one such example where the interface is so skeuomorphic that is often considered a hardware simulator. People who have past experience with such hardware often love Reason because they are able to draw upon past experience to understand the interface. I suppose in this case, this is a very appropriate use of skeuomorphism.
People like me who don't have experience with such hardware aren't necessarily going to appreciate this, though some people will enjoy it even without past experience with hardware because some people simply enjoy visually appealing graphical interfaces. So it's a tough call which group of people is in the majority and who you want to cater to. Personally I like music/audio software to focus on it's core task of being a music creation tool, and less on being graphically impressive; but that's just me.