Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Twice-Yearly HIV Shot Shows 100% Effectiveness in Women

apnews.com

Post reply on HN
Print view View original

51–60 of 163 posts

Re: Twice-Yearly HIV Shot Shows 100% Effectiveness in Women

#51

Post by gadders »

sausagefeet wrote: post #41
gadders wrote: post #39

Earlier quoted context omitted.

>>You, trying to put this on the people, is pretty despicable. To be clear, I am talking about in first world countries where people have more agency and are expected to take responsibility for their own health.

Really? That makes it better? Living in the first world country means you don't make very human mistakes? It means life doesn't get in the way sometimes? Look, your view seems to be "people in first world countries should be acting how I think they should act, and I just can't imagine myself getting into this situation so that means they can't, and thus I'm going to treat them like they did something wrong". You don'…

I think people should take responsibility for themselves. It's not a hard concept to understand. It's part of adulthood.

Re: Twice-Yearly HIV Shot Shows 100% Effectiveness in Women

#52

Post by saagarjha »

gadders wrote: post #51
sausagefeet wrote: post #41

Earlier quoted context omitted.

Really? That makes it better? Living in the first world country means you don't make very human mistakes? It means life doesn't get in the way sometimes? Look, your view seems to be "people in first world countries should be acting how I think they should act, and I just can't imagine myself getting into this situation so that means they can't, and thus I'm going to treat them like they did something wrong". You don'…

I think people should take responsibility for themselves. It's not a hard concept to understand. It's part of adulthood.

Adult living in the first world, among other adults living in the first world. Where I'm from designing for people "not making mistakes" is considered to be unconscionable and negligent. The fact that people (yes, everyone) makes mistakes is well studied and statistically backed, so any solution you have where they just "take responsibility" will not work.

Re: Twice-Yearly HIV Shot Shows 100% Effectiveness in Women

#53

Post by saagarjha »

2Gkashmiri wrote: post #46
t-writescode wrote: post #15

Earlier quoted context omitted.

You need to be in the same place, at the same time, every day, and always have them with you, continually. You also need to keep them dry and at room temperature all the time, so no leaving them in your car. Here's another example of a pill that needs to be taken every day, at approximately the same time of day: https://www.plannedparenthood.org/learn/birth-control/birth-... From this article on that pill, > But peop…

https://en.m.wikipedia.org/wiki/Directly_observed_treatment,... This is already possible by DOTS. In India it did wonders

> Directly observed treatment

For a sexually transmitted disease? Harder than you'd expect, considering people are reticent about their private lives.

> short-course

This needs to be continued forever, as far as I understand.

Re: Twice-Yearly HIV Shot Shows 100% Effectiveness in Women

#54

Post by fennecbutt »

thaumasiotes wrote: post #11
t-writescode wrote: post #2

This is incredibly exciting! The main method available for PrEP, in the United States, at least, is a daily pill. I think (I don't know) there is a monthly shot, too. Daily pills take a lot of time investment; monthly shots are better; but once every 6 months is awesome! Especially in circumstances where it might be difficult to guarantee a daily pill or even a monthly shot.

> Daily pills take a lot of time investment; monthly shots are better That is a matter of opinion. How much time do you think it takes to swallow a pill?

As someone who takes prep what a silly question.

Of course it's easier to get a shot than to take individual pills, I think people would universally agree on that.

Also with prep, since you have to continue dosing 2 days after last activity you get awkward situations where you left it at home or get distracted by life events.

I think this is more common because most people do event based dosing rather than continuous (which would form a habit of taking it every day).

Re: Twice-Yearly HIV Shot Shows 100% Effectiveness in Women

#55

Post by thaumasiotes »

n4r9 wrote: post #44
b112 wrote: post #26

Earlier quoted context omitted.

Interesting. Such variance in humans. I find such things inordinately simple. I wake, stretch, urinate, go take my vitamins and drink two glasses of water. A third follows me to my current home office, where I process emails, alerts, whatever may be. I find the best time to triage overnight emails is when I'm not quite awake yet to realise I'm doing it. Less pain that way. The key is it being part of a routine, and t…

How do you ensure that you always have a sufficient stock of vitamins either you, despite being in a different part of the world on a weekly basis? Do you have kids, if so how do you deal with frequent disruptions to the morning routine? Do you not have days where you just need to get up and go e.g. to catch a flight, get to a meeting, take a kid to school, or because you stayed up late and got drunk, etc... and taki…

> Do you have kids, if so how do you deal with frequent disruptions to the morning routine? Do you not have days where you just need to get up and go e.g. to catch a flight, get to a meeting, take a kid to school, or because you stayed up late and got drunk, etc... and taking vitamins took a back seat?

This is crazy. You deal with the morning routine by taking your pills when the alarm goes off, because there's nothing the kids can be doing that won't wait for that.

Flying, driving, and driving are exactly the same. Take your pill when the alarm goes off.

If you drank so much that it rendered you unconscious through the time you needed to take your pill, the solution is "don't do that". That's not exactly an unavoidable necessity of life.

Re: Twice-Yearly HIV Shot Shows 100% Effectiveness in Women

#56

Post by b112 »

n4r9 wrote: post #44
b112 wrote: post #26

Earlier quoted context omitted.

Interesting. Such variance in humans. I find such things inordinately simple. I wake, stretch, urinate, go take my vitamins and drink two glasses of water. A third follows me to my current home office, where I process emails, alerts, whatever may be. I find the best time to triage overnight emails is when I'm not quite awake yet to realise I'm doing it. Less pain that way. The key is it being part of a routine, and t…

How do you ensure that you always have a sufficient stock of vitamins either you, despite being in a different part of the world on a weekly basis? Do you have kids, if so how do you deal with frequent disruptions to the morning routine? Do you not have days where you just need to get up and go e.g. to catch a flight, get to a meeting, take a kid to school, or because you stayed up late and got drunk, etc... and taki…

I don't have much issue with buying vitamins, because I take them with me. Just as I take toothpaste, etc. If I am there long enough to need more vitamins, it is in the same category as needing more toothpaste, and you resupply as you would at home.

No kids. I do have emergency paging and downed server / PROD to deal with 24/7, not the same as kids, but wake-disrupting all the same.

There is rarely something urgent enough to prevent urinating in the morning, and being thirsty after waking up is typcially a no go either. If prod is down maybe I'll eval first, but humans need out and in of water. I'm not going to urinate on the floor, and I'm not going to sit dehydrated and parched mouth for long either.

So wake, urinate, drink and vitamins are in that too.

My vitamins are in the bathroom, and it takes less than 10 seconds to consume them.

Re: Twice-Yearly HIV Shot Shows 100% Effectiveness in Women

#57

Post by kolinko »

n4r9 wrote: post #44
b112 wrote: post #26

Earlier quoted context omitted.

Interesting. Such variance in humans. I find such things inordinately simple. I wake, stretch, urinate, go take my vitamins and drink two glasses of water. A third follows me to my current home office, where I process emails, alerts, whatever may be. I find the best time to triage overnight emails is when I'm not quite awake yet to realise I'm doing it. Less pain that way. The key is it being part of a routine, and t…

How do you ensure that you always have a sufficient stock of vitamins either you, despite being in a different part of the world on a weekly basis? Do you have kids, if so how do you deal with frequent disruptions to the morning routine? Do you not have days where you just need to get up and go e.g. to catch a flight, get to a meeting, take a kid to school, or because you stayed up late and got drunk, etc... and taki…

Not vitamins but vrious meds in my case. And a very chaotic lifestyle at times.

The meds are always next to bed, and a pouch with meds for when I travel, plus a set of them in my backpack in case I sleep out of home.

When I was in a relationship and we lived separately, I had two sets - one on my place, another in my gf’s place.

It’s a bit like “how do you manage to brush your teeth daily if you have a chaotic routine”.

Re: Twice-Yearly HIV Shot Shows 100% Effectiveness in Women

#58

Post by dbbk »

fennecbutt wrote: post #54
thaumasiotes wrote: post #11

Earlier quoted context omitted.

> Daily pills take a lot of time investment; monthly shots are better That is a matter of opinion. How much time do you think it takes to swallow a pill?

As someone who takes prep what a silly question. Of course it's easier to get a shot than to take individual pills, I think people would universally agree on that. Also with prep, since you have to continue dosing 2 days after last activity you get awkward situations where you left it at home or get distracted by life events. I think this is more common because most people do event based dosing rather than continuous…

I mean broadly yes but not universally. Some people have fears of needles etc.

Re: Twice-Yearly HIV Shot Shows 100% Effectiveness in Women

#59

Post by viraptor »

thaumasiotes wrote: post #55
n4r9 wrote: post #44

Earlier quoted context omitted.

How do you ensure that you always have a sufficient stock of vitamins either you, despite being in a different part of the world on a weekly basis? Do you have kids, if so how do you deal with frequent disruptions to the morning routine? Do you not have days where you just need to get up and go e.g. to catch a flight, get to a meeting, take a kid to school, or because you stayed up late and got drunk, etc... and taki…

> Do you have kids, if so how do you deal with frequent disruptions to the morning routine? Do you not have days where you just need to get up and go e.g. to catch a flight, get to a meeting, take a kid to school, or because you stayed up late and got drunk, etc... and taking vitamins took a back seat? This is crazy. You deal with the morning routine by taking your pills when the alarm goes off, because there's nothi…

> because there's nothing the kids can be doing that won't wait for that.

I feel you don't have young kids then. Jumping on you, bleeding, having a nightmare, making possibly-chocking-sounds, running away with your pills, vomiting on the floor, etc. will definitely take priority over whatever you thought you were going to do after waking up. And that doesn't even touch on people with executive functions issues. Or the 1-2yo period where the time you officially wake up may be often a very fuzzy concept. (You mean the 5am wake-up, the 5.45 one, or the getting up after not falling asleep)

Re: Twice-Yearly HIV Shot Shows 100% Effectiveness in Women

#60

Post by mike_hearn »

Fomite wrote: post #12
Aardwolf wrote: post #3

> and results published Wednesday show it worked nearly as well in men. So not as well? Is there a biological reason for this? Also, is it typical to do such studies on single genders rather than on a mix of humans?

A few reasons: - Women and girls make up the majority of HIV cases, especially in the developing world - If you're estimating the effect in both men and women, you're reducing your power to detect an effect in either group. If you have a limited budget, it's going to be hard to recruit, etc., you may well be better off powering your study for the group you think is going to be the most impactful, then going back. We…

That's inaccurate. The vast majority of all cases are in men. For instance in America only 22% of HIV+ people are women. Our World In Data has a map that shows this visually:

https://ourworldindata.org/hiv-aids

The only place this isn't true is sub-Saharan Africa. As there's no biological explanation for that discrepancy it's been hypothesized that it's because in Africa a lot of reported HIV cases are fraudulent, due to the large amount of AIDS/women specific foreign aid money and weak auditing standards.

Post reply on HN