Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes • Hacker News Board

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#51

Post by 93po » Thu, Oct 24, 2024, 6:39 PM UTC

throwaway041207 wrote: post #36

thepasswordis wrote: post #18

Of all things my taxes go to, I would love it the United States Government would buy the patent for this drug and make it freely available to anybody who wants it. The number of things it apparently just cures is staggering.

I have been on compounded GLP-1 for a month, prior to this I was a highly functional alcoholic, basically starting drinking after work every night and going until I passed out. I've drunk well over 50 beers (probably more) a week for the last 20 years. I have not had a drink since going on it. I have been reading obsessively about this drug since going on it. I have been fortunate enough not to suffer side effects on…

do you have adhd, and do you think your drinking is at all related to adhd/lack of executive function? just curious, not implying.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#52

Post by myprotegeai » Thu, Oct 24, 2024, 6:40 PM UTC

EliRivers wrote: post #40

myprotegeai wrote: post #29

Earlier quoted context omitted.

Yeah, what could go wrong with screwing with the neurochemical reward system of the entire population. Surely that will have no unintended side effects. It's literally a free lunch!

what could go wrong with screwing with the neurochemical reward system of the entire population We already know what can go wrong. We already did that decades and decades ago. Sugar, for example. Aside from so many foods being laced with it, you can now simply walk into a store and buy a kilogram of sugar and eat it. So many other examples. That ship sailed a long long time ago. All we can do now is nudge the dial th…

Because you can buy sugar from the store, having the US subsidize ozempic for for the entire population makes logical sense. Got it.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#53

Post by [deleted] » Thu, Oct 24, 2024, 6:41 PM UTC

sandworm101 wrote: post #42

cthalupa wrote: post #32

Earlier quoted context omitted.

I’ll make my usual response: we know that being obese is basically the worst possible thing you can do to yourself, and the longer you are, the worse it is. The side effects are going to be pretty awful just to negate that, much less all the other things they seem to be good for.

>> being obese is basically the worst possible thing you can do to yourself Lol. I can think of dozens of worse things. Drinking. Cocaine addiction. Meth. Winding up in prison for some reason. Riding a motorcycle without a proper helmet. Getting into a plane flown by Harrison Ford. Even simple unprotected sex can lead to massive medical problems. Ever looked up the average life expectancy of professional athletes, es…

[deleted]

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#54

Post by sandworm101 » Thu, Oct 24, 2024, 6:41 PM UTC

thepasswordis wrote: post #18

Of all things my taxes go to, I would love it the United States Government would buy the patent for this drug and make it freely available to anybody who wants it. The number of things it apparently just cures is staggering.

>> The number of things it apparently just cures is staggering.

It cures behavior, not directly disease. I see red flags. Firefly did a movie about a drug that interfered with people's motivations to do things.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#55

Post by Spooky23 » Thu, Oct 24, 2024, 6:41 PM UTC

declan_roberts wrote: post #8

How do you isolate this from the therapeutic benefits of simply losing weight and being skinny?

Omg, you figured it out! Shit.

All we need to do is just tell a few million people to lose weight.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#56

Post by myprotegeai » Thu, Oct 24, 2024, 6:42 PM UTC

keeganpoppen wrote: post #49

myprotegeai wrote: post #29

Earlier quoted context omitted.

Yeah, what could go wrong with screwing with the neurochemical reward system of the entire population. Surely that will have no unintended side effects. It's literally a free lunch!

oh, so i guess you live outside and hunt animals for food? how's your all-natural neurochemical reward system?

If I'm not completely natural, then the entire population should have access to subsidized ozempic. Got it.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#57

Post by lawrenceyan » Thu, Oct 24, 2024, 6:42 PM UTC

Why not just lose weight by eating less? I know that sounds like a dumb question.

But genuinely, aren’t you just paying money to… not spend the money on food instead?

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#58

Post by bearjaws » Thu, Oct 24, 2024, 6:43 PM UTC

loeg wrote: post #30

thepasswordis wrote: post #18

Of all things my taxes go to, I would love it the United States Government would buy the patent for this drug and make it freely available to anybody who wants it. The number of things it apparently just cures is staggering.

Novo Nordisk's market cap is $500 B, mostly on the basis of GLP-1 drug profits, and the US' entire discretionary budget is $1,700 B. Even if Denmark would allow the sale, and even if somehow the US did not need to pay a premium to shareholders (typical in acquisitions), that would still be a very substantial expenditure.

This ignores the fact that the patents expire in 5-7 years, GLP1 is (relatively) trivial to produce and will be a $100 generic by 2032.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#59

Post by tombert » Thu, Oct 24, 2024, 6:44 PM UTC

sandworm101 wrote: post #54

thepasswordis wrote: post #18

Of all things my taxes go to, I would love it the United States Government would buy the patent for this drug and make it freely available to anybody who wants it. The number of things it apparently just cures is staggering.

>> The number of things it apparently just cures is staggering. It cures behavior, not directly disease. I see red flags. Firefly did a movie about a drug that interfered with people's motivations to do things.

Are you seriously suggesting that Ozempic might lead to the Reavers from Firefly?

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#60

Post by Someone1234 » Thu, Oct 24, 2024, 6:44 PM UTC

nordsieck wrote: post #31

Someone1234 wrote: post #7

Earlier quoted context omitted.

With the constant stream of positive news around GLP-1s, and ever-growing list of things they treat, we may all wind up on some dose with only the dose varying depending on what illness they're targeting.

> With the constant stream of positive news around GLP-1s, and ever-growing list of things they treat, we may all wind up on some dose with only the dose varying depending on what illness they're targeting. So far, I haven't seen much evidence that GLP-1s have a positive effect on people who aren't overweight. And while I'll be the first to admit that the proportion of people who could benefit from these drugs is qui…

> So far, I haven't seen much evidence that GLP-1s have a positive effect on people who aren't overweight.

It is licensed, tested, and sold as a Type-2 Diabetes medication. Are you claiming it is ineffective for that purpose? Or if you're under the impression that no healthy weight T2 Diabetics exist, I have some news for you...

It is also being studied for: opioid addiction, alcoholism, Alzheimer's/Parkinson’s, Cardiovascular Disease, NASH, and PCOS.

"So far, I haven't seen evidence" may be more related to what you have read than what is available for you to read.