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Psilocybin bests SSRI for major depression in first long-term comparison

medscape.com

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Re: Psilocybin bests SSRI for major depression in first long-term comparison

#51

Post by jdietrich »

fullspectrumdev wrote: post #46
dillydogg wrote: post #9

I think a major criticism of how this study is designed is that it is not truly "blinded". I doubt many of the participants were unsure if they received psilocybin vs escitalopram. That being said, there are a number of studies that suggest this is an effective treatment, so I hope this can become more available to those who need it. However, for treatment resistant depression (especially with a catatonia component),…

The doses of psilocybin being used were so low as to be barely perceptible.

The participants received a 25mg dose; I can assure you that such a dose is very much perceptible.

https://www.thelancet.com/journals/eclinm/article/PIIS2589-5...

Re: Psilocybin bests SSRI for major depression in first long-term comparison

#52

Post by [deleted] »

vlabakje90 wrote: post #48
infamouscow wrote: post #36

Earlier quoted context omitted.

Psilocybin tolerance starts building immediately. Even if you microdose (100 mg), it will stop being effective after 3-4 days.

100mg psilocybin is several times a heroic dose, but 100ug is far below a microdose. Do you mean 100mg of dried mushrooms?

[deleted]

Re: Psilocybin bests SSRI for major depression in first long-term comparison

#53

Post by dymk »

vlabakje90 wrote: post #48
infamouscow wrote: post #36

Earlier quoted context omitted.

Psilocybin tolerance starts building immediately. Even if you microdose (100 mg), it will stop being effective after 3-4 days.

100mg psilocybin is several times a heroic dose, but 100ug is far below a microdose. Do you mean 100mg of dried mushrooms?

I think he means 100mg of mushroom body, which might be 1-2mg of psilocybin.

Re: Psilocybin bests SSRI for major depression in first long-term comparison

#54

Post by dymk »

Jerrrrrrry wrote: post #30
awestroke wrote: post #4

I wonder how much of an uphill battle it will be to get psilocybin approved for therapeutic use compared to synthetic psilocybin analogues that are being trialed right now. Psilocybin can't be patented and it's already scheduled as a narcotic everywhere.

The 2018 Hemp Farm bill gave the balls back to the citizens that the 2013 Analag act neutered. Seeing mushroom extracts with all the alkaloids included besides psilocybin at gas stations may be a temporary point of stability until I can go to the "21+" store in 2030 to get my preferred arylcyclohexylamine and phenylethylamine variant.

From what I understand, those “magic mushroom” edibles sold in head shops and gas stations are amanita muscaria derived, which is a completely different psychoactive substance with different alkaloids. Toxic to the liver too, in ways that a cubensis is not.

Re: Psilocybin bests SSRI for major depression in first long-term comparison

#56

Post by cubefox »

Unfortunately it's hardly possible to do proper case control studies with psilocybin, since the psychedelic effects cause unblinding. The participants know whether they are in the treatment or control group.

> Normally the journey is quite inward, so patients do not require active support during the psychedelic experience [around 6 hours]. Sometimes they do require some hand-holding, or helping them to 'let go', or breathing exercises. The important part is the integration work that comes afterwards," Barba added. [...]

> However, [Rucker] noted, it is also possible that the results reflect biased reporting between groups. This is more likely here because studies involving psilocybin tend to attract those with positive preconceptions about psilocybin and negative preconceptions about conventional antidepressants

Re: Psilocybin bests SSRI for major depression in first long-term comparison

#57

Post by dymk »

Muromec wrote: post #17
awestroke wrote: post #4

I wonder how much of an uphill battle it will be to get psilocybin approved for therapeutic use compared to synthetic psilocybin analogues that are being trialed right now. Psilocybin can't be patented and it's already scheduled as a narcotic everywhere.

I doubt about everywhere, as shrooms are sold in shop around here.

In the US, those aren’t from mushrooms that contain psilocybin or related neurotransmitter analogs

Re: Psilocybin bests SSRI for major depression in first long-term comparison

#58

Post by giantg2 »

8b16380d wrote: post #22

Funny, psilocybin has been largely detrimental to the mental health of everyone I know.

"Funny, psilocybin has been largely detrimental to the mental health of everyone I know."

This statemwnt is true for the people I know who have used it in a recreational manner. This statement is also false for the people I who who have self-treated with it in a controlled setting.

Re: Psilocybin bests SSRI for major depression in first long-term comparison

#59

Post by erie »

bitcurious wrote: post #45
ValentinA23 wrote: post #5

https://en.wikipedia.org/wiki/Selective_serotonin_reuptake_i... >Post-SSRI sexual dysfunction (PSSD)[62][63] refers to a set of symptoms reported by some people who have taken SSRIs or other serotonin reuptake-inhibiting (SRI) drugs, in which sexual dysfunction symptoms persist for at least three months[64][65][66] after ceasing to take the drug. The status of PSSD as a legitimate and distinct pathology is contentiou…

Can psilocybin restore the mojo, or are you just commenting on the downside of SSRIs?

One dude recounted how psilocybin helped him have the best experience with the happy ending , as being out of this world, but the timing was perfect, not sure if it was 'How to Change Your Mind | | Netflix, or another one there.

Re: Psilocybin bests SSRI for major depression in first long-term comparison

#60

Post by teaearlgraycold »

cubefox wrote: post #56

Unfortunately it's hardly possible to do proper case control studies with psilocybin, since the psychedelic effects cause unblinding. The participants know whether they are in the treatment or control group. > Normally the journey is quite inward, so patients do not require active support during the psychedelic experience [around 6 hours]. Sometimes they do require some hand-holding, or helping them to 'let go', or b…

You could compare against other psychedelics. I’d be interested in that.
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