In the future they may find two antagonistic vulnerabilities. Evolving resistance to one vulnerability makes you more vulnerable to the other.
Dual action antibiotic could make bacterial resistance nearly impossible
51–60 of 87 posts
Re: Dual action antibiotic could make bacterial resistance nearly impossible
#52Re: Dual action antibiotic could make bacterial resistance nearly impossible
#53It’s unclear why the same benefit couldn’t be achieved by mixing two traditional antibiotics with different mechanisms of action. Maybe the combined dosage would stress the liver too much?
Trimethoprim/sulfamethoxazole is a widely used such combination antibiotic. "Trimethoprim/sulfamethoxazole, sold under the brand name Bactrim among others, is a fixed-dose combination antibiotic medication used to treat a variety of bacterial infections." https://en.wikipedia.org/wiki/Trimethoprim/sulfamethoxazole
To rephrase didgeoridoo :
What are the advantage/drawbacks of the article method over Bactrim method ?
Re: Dual action antibiotic could make bacterial resistance nearly impossible
#54> 100 million times do you know how many bacteria, all mutating and swapping genes, there are out there? also, dual therapy, particularly for TB has been used for years, but TB is still with us.
But drug resistance is already really hard to develop. As you say, there are an almost unfathomable number of -- let's say staph -- bacteria running around, infecting millions of people per year, and still it's taken most of a century to develop MRSA. 100 million times might make MRSA v2 take millennia to arrive.
As we see an exponential grow or the human population, shouldn’t your estimation for v2 be pondered compared to v1 development?
Re: Dual action antibiotic could make bacterial resistance nearly impossible
#55[flagged]
Yes. He mentioned the controversy and the arguments (and his biases) but refrains from preaching or privileging one side over the other, instead electing to express joy and wonder.
I was pretty impressed with his approach, so I'll link the relevant section below (last ~3m). I'd argue abstaining from viewing (and commenting as much) is evangelizing more than Destin here.
Re: Dual action antibiotic could make bacterial resistance nearly impossible
#56Earlier quoted context omitted.
> mostly plants. This is in general good advice, but in the context of healing the liver plants are generally the type of poison your liver exists to filter in the first place, so a meat heavy diet is likely better. Of course you are trading longer term cardiovascular health for short term liver healing so don't do this for long, but if your liver is very damaged avoid plants as well for a short term.
That may seem logical, but actual testing shows a largely plant based diet is actually better for the liver. Enterohepatic Recirculation is heavily influenced by diet which is why fiber and specifically leafy greens seem to be helpful for liver heath. https://en.wikipedia.org/wiki/Enterohepatic_circulation This is also one of the reasons activated charcoal is useful after ingesting a wide range of harmful substances.
> This is also one of the reasons activated charcoal is useful after ingesting a wide range of harmful substances.
I don't see the connection to what you wrote before it; would you mind to explain?
Re: Dual action antibiotic could make bacterial resistance nearly impossible
#57Earlier quoted context omitted.
That may seem logical, but actual testing shows a largely plant based diet is actually better for the liver. Enterohepatic Recirculation is heavily influenced by diet which is why fiber and specifically leafy greens seem to be helpful for liver heath. https://en.wikipedia.org/wiki/Enterohepatic_circulation This is also one of the reasons activated charcoal is useful after ingesting a wide range of harmful substances.
> This is also one of the reasons activated charcoal is useful after ingesting a wide range of harmful substances. I don't see the connection to what you wrote before it; would you mind to explain?
The primary method of action for activated charcoal is to bind to a substance in the digestive system and prevent its absorption into the body.
Unfortunately there can be a significant delay between ingesting the toxin and activated charcoal. However, substances can pass in both directions. So by lowering the concentration in the intestine it also increases the amount that diffuses back into the intestines after having entered the bloodstream.
Re: Dual action antibiotic could make bacterial resistance nearly impossible
#58Earlier quoted context omitted.
Trimethoprim/sulfamethoxazole is a widely used such combination antibiotic. "Trimethoprim/sulfamethoxazole, sold under the brand name Bactrim among others, is a fixed-dose combination antibiotic medication used to treat a variety of bacterial infections." https://en.wikipedia.org/wiki/Trimethoprim/sulfamethoxazole
To rephrase didgeoridoo : What are the advantage/drawbacks of the article method over Bactrim method ?
i think with combination antibiotics, you can’t guarantee that nobody in the world is using one of them on their own
Re: Dual action antibiotic could make bacterial resistance nearly impossible
#59Earlier quoted context omitted.
But drug resistance is already really hard to develop. As you say, there are an almost unfathomable number of -- let's say staph -- bacteria running around, infecting millions of people per year, and still it's taken most of a century to develop MRSA. 100 million times might make MRSA v2 take millennia to arrive.
As we see an exponential grow or the human population, shouldn’t your estimation for v2 be pondered compared to v1 development?
I dont think you understand the word exponential.
Re: Dual action antibiotic could make bacterial resistance nearly impossible
#60Earlier quoted context omitted.
> This is also one of the reasons activated charcoal is useful after ingesting a wide range of harmful substances. I don't see the connection to what you wrote before it; would you mind to explain?
The primary method of action for activated charcoal is to bind to a substance in the digestive system and prevent its absorption into the body. Unfortunately there can be a significant delay between ingesting the toxin and activated charcoal. However, substances can pass in both directions. So by lowering the concentration in the intestine it also increases the amount that diffuses back into the intestines after havi…
Thanks, now I understand.