Certainly they can disintegrate negative connections. Be warned however, they can also do the same with the positive ones. The chemicals used don’t care about the outcome of their use.
I was acquaintanced with a guy who had safely taken significant amounts of shrooms for years (he asserts more therapeutic reasons than recreational), having slowly tested up to ~5grams, so was seemingly in the clear are far as uncovering schizophrenia and the like. Then he took a bit more one day, he estimates about 7grams, and basically his connection with his sense of body and presence in the world became severed. Described it like being dead, but trapped in a body, unable to feel joy or relationships. This persisted for 3 years despite many attempts to resolve it. In the end he committed suicide.
While things like microdosing are definitely intriguing, my own exploration on the topic and reading many accounts has left me with the strong impression that for psilocybin, any dosage above 3grams (of dry Psilocybe cubensis) poses an unacceptable risk of negative outcomes.
As such, I strongly caution against naive exploration, and stay the hell away from higher doses. Especially since those seeking psychedelics as a treatment are much more likely to have multiple issues that increase the likelihood of severely negative outcomes. Users should also be aware that under elevated doses, self harm or harm to others becomes possible. Assaults, murders, and suicides under the influence are a reality that cannot morally just be ignored.
Which brings up another point; in general the psychedelic communities online that I’ve observed do not generally appreciate the mention of bad outcomes, to the point where they actively censor things as anti-psychedelic conspiracy. That coupled with problems in getting accurate medical data make it hard to tell the actual rate of severely negative outcomes. Those who take psychedelics have a vested interest in seeing only the good outcomes.