My biggest complaint with gRPC is proto3 making all nested type fields optional while making primitives always present with default values. gRPC is contract based so it makes no sense to me that you can't require a field. This is especially painful from an ergonomics viewpoint. You have to null check every field with a non primitive type.
If I remember correctly the initial version allowed required fields but it caused all sorts of problems when trying to migrate protos because a new required fields breaks all consumers almost by definition. So updating protos in isolation becomes tricky. The problem went away with all optional fields so it was decided the headache wasn't worth it.
I suspect that not having nullable fields, though, is just a case of letting an implementation detail, keeping the message representation compatible with C structs in the core implementation, bleed into the high-level interface. That design decision is just dripping with "C++ programmers getting twitchy about performance concerns" vibes.