Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Ozempic will disrupt big tobacco, candy companies, and alcohol brands

curingaddiction.substack.com

Post reply on HN
Print view View original

51–60 of 214 posts

Re: Ozempic will disrupt big tobacco, candy companies, and alcohol brands

#51

Post by PierceJoy »

spirit557 wrote: post #36
akgoel wrote: post #7

Earlier quoted context omitted.

When I was on Ozempic, I just didn't want the milkshake. It rewires all reward centers.

You cant take these drugs forever afaik. Do they have permanent effects? It's just absurd to me the world has come to the point that we need these drugs in the first place but it makes total sense when you look at America for example. Awash in hyperpalatable processed "food" and corrupt food guidelines, a medical industry that "manages" chronic metabolic preventable disease but never cures it when probably 99% of cas…

On the contrary, most weight loss doctors consider these drugs to be like statins. You take them for the rest of your life. The number of people who maintain healthy habits after stopping them is shockingly low.

Re: Ozempic will disrupt big tobacco, candy companies, and alcohol brands

#52

Post by galangalalgol »

odiroot wrote: post #38
akgoel wrote: post #7

Earlier quoted context omitted.

When I was on Ozempic, I just didn't want the milkshake. It rewires all reward centers.

If they invent something like this but for procrastination, they'd get a Nobel prize.

It is called dexamphetamine. Or more more commonly these days, lysdexamphetamine.

Re: Ozempic will disrupt big tobacco, candy companies, and alcohol brands

#53

Post by JumpCrisscross »

spirit557 wrote: post #36
akgoel wrote: post #7

Earlier quoted context omitted.

When I was on Ozempic, I just didn't want the milkshake. It rewires all reward centers.

You cant take these drugs forever afaik. Do they have permanent effects? It's just absurd to me the world has come to the point that we need these drugs in the first place but it makes total sense when you look at America for example. Awash in hyperpalatable processed "food" and corrupt food guidelines, a medical industry that "manages" chronic metabolic preventable disease but never cures it when probably 99% of cas…

> absurd to me the world has come to the point that we need these drugs in the first place

GLP-1 looks increasingly like a miracle drug. We see problems of addiction and obesity skyrocketing across the developing world. It’s not cost free, but it’s a hell of a lot better than the majority of America, China and India becoming potatoes.

When vitamins were discovered, there was similar moralising about there being no free lunch. With the benefit of hindsight those concerns were misfounded. Perhaps Ozempic has terrible side effects that haven’t been noticed since 2005. Given that timeline, however, we can confidently say someone obese taking the drug is better off with it.

> never cures it

I have friends who took it, lost weight and then stopped. The rebound was real but nowhere close to what they lost. (The lifestyle changes also mostly stuck.) For all practical purposes, their fatness was cured.

> when probably 99% of cases could be reversed naturally

Scientifically unfounded.

Re: Ozempic will disrupt big tobacco, candy companies, and alcohol brands

#54

Post by kgwgk »

jakub_g wrote: post #30
raziel2701 wrote: post #17

Ozempic costs $1000/month (in the US) but $5/month to manufacture [0]. I think if this drug and others are to have a significant anti-consumption effect on other companies it needs to be vastly more accessible, which first requires more accessible healthcare in the US, which is unlikely to happen. Also it's an injection, which raises the barrier. If drugs like these become orally administered and over-the-counter, th…

In worst case, Ozempic patents expire in 2031, which is not that far.

The worst case is worse than that: in addition to composition of matter patents there are dosage patents that can be invoked.

https://www.fiercepharma.com/pharma/novo-nordisk-patent-sema...

Re: Ozempic will disrupt big tobacco, candy companies, and alcohol brands

#55

Post by kelseyfrog »

chpatrick wrote: post #34
akgoel wrote: post #7

Earlier quoted context omitted.

When I was on Ozempic, I just didn't want the milkshake. It rewires all reward centers.

But it still doesn't sound like a sustainable lifetime solution. I think it makes great sense if you're badly out of shape, you fix it, and then you can maintain a healthy weight. But going on ozempic every few years sounds really bad.

"Sounds really bad" is orthogonal to "is really bad".

There's a heuristic that goes, "Shortcuts will catch up to people eventually," but I'm ok with letting the evidence bear that out.

Re: Ozempic will disrupt big tobacco, candy companies, and alcohol brands

#56

Post by EugeneOZ »

raziel2701 wrote: post #17

Ozempic costs $1000/month (in the US) but $5/month to manufacture [0]. I think if this drug and others are to have a significant anti-consumption effect on other companies it needs to be vastly more accessible, which first requires more accessible healthcare in the US, which is unlikely to happen. Also it's an injection, which raises the barrier. If drugs like these become orally administered and over-the-counter, th…

Rybelsus is available in tablets and costs €130 in Spain.

Re: Ozempic will disrupt big tobacco, candy companies, and alcohol brands

#57

Post by glp1guide »

Xenoamorphous wrote: post #9

I'm not very familiar with the approval process for new drugs, but as far as I know it involves some initial step where the safety is assessed, and then the effectiveness. But I don't think either of those are actually long term processes (like, longer than 5 years). So it scares me a bit when something like Ozepmic pops up and tons of people jump on it, without knowing the long term effects that might appear. I read…

Hey don't worry, your fears are mostly unfounded -- GLP1 Receptor Agonists have been an effective treatment method for type 2 diabetes for a very long time. They're well studied, researched and trialed, at this point, and many side effects are known.

I'm a bit biased of course (I do a lot of trying to keep up with the research and effects of GLP1 drugs), but I honestly don't think the weight loss scene has seen something so effective and safe for a very long time.

Re: Ozempic will disrupt big tobacco, candy companies, and alcohol brands

#58

Post by [deleted] »

fyt2024 wrote: post #35
Xenoamorphous wrote: post #9

I'm not very familiar with the approval process for new drugs, but as far as I know it involves some initial step where the safety is assessed, and then the effectiveness. But I don't think either of those are actually long term processes (like, longer than 5 years). So it scares me a bit when something like Ozepmic pops up and tons of people jump on it, without knowing the long term effects that might appear. I read…

Yes. I am very worried about the long term effects of this. While I have no need for this drug, I worries me for the broad population. There are problems known already (cancer). I understand that it is a trade off if you are obese. A buddy of mine died with 43 bc a combination of obesity and COVID. Yes, it might be justified for high risk patients but currently it looks like it will become a life style drug like Viag…

[deleted]

Re: Ozempic will disrupt big tobacco, candy companies, and alcohol brands

#59

Post by a1445c8b »

Xenoamorphous wrote: post #9

I'm not very familiar with the approval process for new drugs, but as far as I know it involves some initial step where the safety is assessed, and then the effectiveness. But I don't think either of those are actually long term processes (like, longer than 5 years). So it scares me a bit when something like Ozepmic pops up and tons of people jump on it, without knowing the long term effects that might appear. I read…

> So it scares me a bit when something like Ozepmic pops up and tons of people jump on it, without knowing the long term effects that might appear.

Test in production. YOLO!

Re: Ozempic will disrupt big tobacco, candy companies, and alcohol brands

#60

Post by cactusplant7374 »

When I took Ozempic I had these side effects:

* Low libido and erectile dysfunction * Constipation, diarrhea, and extreme bloating (burping all night long) * Often difficulty sleeping. Waking up a lot. Very restless.

We need a drug that doesn't slow digestion but decreases hunger and increases satiety.

Post reply on HN