This comment section is being heavily censored even for very mild criticisms.
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mRNA vaccines: let's eradicate herpes, cure cancer, and be sick a whole lot less
51–60 of 111 posts
Re: mRNA vaccines: let's eradicate herpes, cure cancer, and be sick a whole lot less
#52This comment section is being heavily censored even for very mild criticisms.
Scary to see this censorship still goes on, even now, at this latter stage, where the studies on myocarditis are numerous and no longer debunked.
The censorship was even worse during the initial rollout of mRNA technology, blocking fair scrutiny of a widespread rollout.
Proper scientific scrutiny and debate is vital around novel technologies. Particularly novel MEDICAL technologies. And particularly where governments are mandating that the technology is administered to whole populations.
Re: mRNA vaccines: let's eradicate herpes, cure cancer, and be sick a whole lot less
#53> RNA is fragile. So, like in the COVID mRNA vaccines, these instructions can be delivered in a protective fatty bubble called a “lipid nanoparticle.” Think of it like a balloon made of fatty acids, with the instructions nestled inside. Once injected, these lipid nanoparticles take the mRNA instructions into cells, where the fatty bubble degrades, mRNA instructions are released, and the cell’s machinery start to prod…
> What makes an mRNA vaccine more appealing than a protein-based one?
Having worked on the same targeting mechanisms for protein based vaccines meant to be personalized cancer therapies, and having followed the mRNA vaccines with envy, the benefits are absolutely massive. But there's not a single alternative. In comparison to each type:
Short peptides injection are worse because: minimal immune stimulation, less of a mechanism to train the immune system on the peptide targets, have not been effective.
Viral delivery of mRNA, that makes proteins, or more exotic methods like yeast with modified genomes: this is a traditional vaccine with a custom viral genome with the peptides of interest added as part of the viral genome. This is not directly a protein virus, but it does make the cells it infects produce the peptides. This requires cell culture to grow the virus, which requires a unique clean room per vaccine, which can be impractical and expensive for a custom virus. It's also very very slow to produce, QC, and make sure it's safe. mRNA production is faster, cleaner, safer, just all around better in every possible way.
As for your other questions, sure they are interesting, but get ready to gear up and read tooooons of literature. Most people don't have any of these questions unless they have a deep distrust of the technology, and don't trust that others have bothered to investigate.
Skepticism is good, and if you are truly curious I really applaud you and encourage you to pick up an immunology text book so that you can also read and understand the papers. But mRNA vaccine skepticism has to be the stupidest "skepticism" and falsehoods I have ever seen of a new technology. As the competitor to what I was working on, I must concede that it's better on all metrics, and I am kind of saddened for humanity that all these lies about mRNA seem to dominate over the true and huge technological advancement that has occurred.
Re: mRNA vaccines: let's eradicate herpes, cure cancer, and be sick a whole lot less
#54> RNA is fragile. So, like in the COVID mRNA vaccines, these instructions can be delivered in a protective fatty bubble called a “lipid nanoparticle.” Think of it like a balloon made of fatty acids, with the instructions nestled inside. Once injected, these lipid nanoparticles take the mRNA instructions into cells, where the fatty bubble degrades, mRNA instructions are released, and the cell’s machinery start to prod…
What makes it more appealing is that you can change the mRNA sequence and change the proteins that are created, meaning you can make arbitrary proteins. Traditional vaccines are far less flexible like that since the process to create proteins has more steps
Re: mRNA vaccines: let's eradicate herpes, cure cancer, and be sick a whole lot less
#55> Why are mRNA vaccines the future? This may well be true, but I’ll be far more likely to believe it when there’s an mRNA vaccine that’s anywhere near as effective as the best old boring vaccines. (I admit that my personal favorite, not-mRNA, HSV vaccine candidate is from a company, X-vax, that appears to have forgotten to renew its domain.) I’m also not entirely clear about the path by which mRNA technology might el…
The covid mRNA vaccines were wildly effective at the original covid strain—95%. But respiratory viruses mutate like crazy.
Re: mRNA vaccines: let's eradicate herpes, cure cancer, and be sick a whole lot less
#56This is about as succinct a summary as it gets re mRNA's potential: "To create an mRNA cancer vaccine, a patient’s tumor is biopsied to identify unique target mutations —> mRNA correlating to mutations is synthesized and injected into the patient —> the patient’s cells create the targeted protein —> the creation of foreign proteins stimulates the immune system and teaches it how to recognize the target protein —> The…
This has a precondition: the existence of targets unique to the cancer cell. That's not necessarily true. In theory you can have cancerous cells that are (at least in the epitope-space) indistinguishable from normal cells. I'm not a doctor, and I guess (and hope) this is an usual case, but finding a truly unique and dissimilar mutation sounds pretty hard, training the immune system to detect it correctly without gene…
It's not that hard, in patients with cancer, it's very common for the immune system to go after the cancer specific mutations, until the cancer learns to express the cell-surface checkpoints that deactivate the immune system.
Its extremely rare (or at least I have not heard of it) to develop auto-immune activity during the course of cancer.
T-cell receptors that recogize HLA-bound epitopes tend to be extremely specific, and rarely go after other parts of the body. There's nothing special about cancer in this regard.
Re: mRNA vaccines: let's eradicate herpes, cure cancer, and be sick a whole lot less
#57Re: mRNA vaccines: let's eradicate herpes, cure cancer, and be sick a whole lot less
#58This comment section is being heavily censored even for very mild criticisms.
Scary to see this censorship still goes on, even now, at this latter stage, where the studies on myocarditis are numerous and no longer debunked. The censorship was even worse during the initial rollout of mRNA technology, blocking fair scrutiny of a widespread rollout. Proper scientific scrutiny and debate is vital around novel technologies. Particularly novel MEDICAL technologies. And particularly where governments…
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Re: mRNA vaccines: let's eradicate herpes, cure cancer, and be sick a whole lot less
#59> Why are mRNA vaccines the future? This may well be true, but I’ll be far more likely to believe it when there’s an mRNA vaccine that’s anywhere near as effective as the best old boring vaccines. (I admit that my personal favorite, not-mRNA, HSV vaccine candidate is from a company, X-vax, that appears to have forgotten to renew its domain.) I’m also not entirely clear about the path by which mRNA technology might el…
The covid mRNA vaccines were wildly effective at the original covid strain—95%. But respiratory viruses mutate like crazy.
They were wildly effective for a few months after being given. We don’t know how well they would continue to work in the absence of mutation.
But it’s worse than that: the revised vaccines appear to be nowhere near as effective even against strains closely related to those which they target. As a somewhat plausible mechanism, repeated doses have been shown to induce IgG4 production, which non-mRNA vaccines don’t seem to do.
Measles and Chickenpox are both airborne, although they’re not respiratory the way Covid is. But their respective vaccines are vastly more effective.
I’m not saying that I know, or have strong evidence, that mRNA vaccines are weak. But I do think it’s fair to say that we have no evidence that they can be comparably effective to earlier vaccine technologies.
Re: mRNA vaccines: let's eradicate herpes, cure cancer, and be sick a whole lot less
#60> RNA is fragile. So, like in the COVID mRNA vaccines, these instructions can be delivered in a protective fatty bubble called a “lipid nanoparticle.” Think of it like a balloon made of fatty acids, with the instructions nestled inside. Once injected, these lipid nanoparticles take the mRNA instructions into cells, where the fatty bubble degrades, mRNA instructions are released, and the cell’s machinery start to prod…
> What makes an mRNA vaccine more appealing than a protein-based one? Having worked on the same targeting mechanisms for protein based vaccines meant to be personalized cancer therapies, and having followed the mRNA vaccines with envy, the benefits are absolutely massive. But there's not a single alternative. In comparison to each type: Short peptides injection are worse because: minimal immune stimulation, less of a…
> Short peptides injection are worse because: minimal immune stimulation, less of a mechanism to train the immune system on the peptide targets, have not been effective.
If the problem of peptide vaccines is weak immune stimulation, then wouldn't the problem of mRNA vaccines be autoimmunity?