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FDA Approves Lilly's Zepbound (Tirzepatide) for Chronic Weight Management

investor.lilly.com

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Re: FDA Approves Lilly's Zepbound (Tirzepatide) for Chronic Weight Management

#51

Post by poopchute »

n8cpdx wrote: post #39
ng12 wrote: post #17

> Research now shows that the body may respond to a calorie-deficit diet by increasing hunger and reducing feelings of fullness Dieting makes you hungry, truly revolutionary research.

It seems obvious but the “just eat less” crowd needs to hear it. Ever try working on a tricky coding project while starving? Take a math test when all you can think about is finding something, anything, to eat? Losing significant amounts of weight the natural way isn’t so much a test of willpower as a test of how well you can function under a constant sense of hunger (or, how good you are at tricking your way out of…

There are quite a few veggies that are low calorie, filling, and are tasty enough to snack on without dip. The ones I eat when I just want to feel full without a bunch of calories are carrots (45 cal/100g), cucumbers (14 cal/100g), sugar snap peas ( 42 cal/100g), and yellow bell pepper (27 cal/100g).

Re: FDA Approves Lilly's Zepbound (Tirzepatide) for Chronic Weight Management

#52

Post by jupp0r »

chimeracoder wrote: post #20
jupp0r wrote: post #13

Earlier quoted context omitted.

From what I understand, Semaglutide is available in compounded form by pharmacies due to a shortage (without end in sight) being declared. https://www.fda.gov/media/173456/download?attachment

> Semaglutide is available in compounded form by pharmacies due to a shortage (without end in sight) being declared. There's much less oversight over the production of compounded drugs, and people who purchase them may not be getting what they expect, with no way to tell the difference. https://www.fda.gov/drugs/postmarket-drug-safety-information...

Absolutely. My comment was more pertaining to patent's being partially suspended, which is not the same as generic fully regulated drugs being available.

Re: FDA Approves Lilly's Zepbound (Tirzepatide) for Chronic Weight Management

#53

Post by belltaco »

rs_rs_rs_rs_rs wrote: post #37
nathanyz wrote: post #16

Earlier quoted context omitted.

This cannot be understated. Obesity is being changed from a willpower problem to a chronic disease that is treatable. The follow-on effects of this are huge.

>Obesity is being changed from a willpower problem to a chronic disease that is treatable It's absolutely a willpower problem. These medications won't fix that for you. You stop taking them and you will gain weight again.

All forms of contraception are also solving a "willpower problem". Food is even more of a basic need compared to sex, so evolution has it made it so that it's really hard to eat less.

Re: FDA Approves Lilly's Zepbound (Tirzepatide) for Chronic Weight Management

#54

Post by molsongolden »

xnx wrote: post #44
candiddevmike wrote: post #19

Earlier quoted context omitted.

What are the side effects? There's never a free lunch with biological systems...

Possibly none. These drugs are bringing our appetite under control in an environmental that is full of readily available, appetizing, easy to digest, high-calorie foods.

I've seen the benefits of these drugs for people close to me but this whole concept still feels a bit dystopian.

Companies selling $500-$1,000/mo drugs to counteract the garbage food and "food products" other companies are producing and marketing to us.

Re: FDA Approves Lilly's Zepbound (Tirzepatide) for Chronic Weight Management

#55

Post by Shekelphile »

molsongolden wrote: post #36

With these drugs, is there any mechanism at work beyond "patients have a lower appetite and eat less food"? I've only read a few papers and articles but what I've seen is that all of the hormone triggering leads to 1) decreased appetite 2) slowed gastric emptying which also decreases appetite. Patients lose weight due to eating less but usually regain the weight when stopping the drug since they then go back to their…

> Are these drugs fixing/replacing a system failure where people don't feel satiated normally? > Can the same effect be replicated by eating a higher fiber and higher fat diet with more whole foods to feel full longer and slow gastric emptying?

I think it simply takes a long time for your body to adjust back to where it should be after a period of extended binging and these drugs make it happen much faster. The only time I consistently lost weight in my life was when I lived in a food desert and had no car and not much money, so I was forced to only buy the cheapest vegetables and meats (usually chicken) and make what I could out of that and make it last for the week. Even then it took more than 6 months before I felt normal eating that way.

Of course, it's extremely easy to fall off the wagon when your body works this way too. Even a day can wipe out weeks of gains and you can always 'relapse' even after months of doing the right thing, and end up stagnating or completely reversing any progress you've made. In a way it seems that food is the most addictive drug of all. You can easily quit alcohol, cigarettes, hard drugs with a couple weeks of willpower (and I have multiple times). You can't ever stop eating food if you want to be around to experience life.

Re: FDA Approves Lilly's Zepbound (Tirzepatide) for Chronic Weight Management

#56

Post by bb88 »

rs_rs_rs_rs_rs wrote: post #37
nathanyz wrote: post #16

Earlier quoted context omitted.

This cannot be understated. Obesity is being changed from a willpower problem to a chronic disease that is treatable. The follow-on effects of this are huge.

>Obesity is being changed from a willpower problem to a chronic disease that is treatable It's absolutely a willpower problem. These medications won't fix that for you. You stop taking them and you will gain weight again.

Hunger is caused by not enough glucagen-like peptides (GLP-1, etc) being distributed to the brain from the gut. Obesity is not so much a food "addiction" as it is the body's failure to properly regulate it's own fullness.

I've heard this called "food noise" by those who are obese. GLP-1 agonists reduce the so called food noise -- that's all it does.

In that light your argument is like trying to tell schizophrenics, "Hey, stop hearing those voices in your head!" I think we tried that for over a century.

Re: FDA Approves Lilly's Zepbound (Tirzepatide) for Chronic Weight Management

#57

Post by bb88 »

molsongolden wrote: post #54
xnx wrote: post #44

Earlier quoted context omitted.

Possibly none. These drugs are bringing our appetite under control in an environmental that is full of readily available, appetizing, easy to digest, high-calorie foods.

I've seen the benefits of these drugs for people close to me but this whole concept still feels a bit dystopian. Companies selling $500-$1,000/mo drugs to counteract the garbage food and "food products" other companies are producing and marketing to us.

Well... when we were like cave men and calories were hard to get, hunger pangs make more sense from an evolutionary standpoint.

But now, through farming technologies, food has never been more abundant. Yes we've saved people from dying of famine, but then the corn producers grew so much more corn that were beyond America's daily dietary need, they then could use much of it for HFCS, say. Or you know, Taco Bell's fourthmeal.

Re: FDA Approves Lilly's Zepbound (Tirzepatide) for Chronic Weight Management

#58

Post by Spooky23 »

molsongolden wrote: post #54
xnx wrote: post #44

Earlier quoted context omitted.

Possibly none. These drugs are bringing our appetite under control in an environmental that is full of readily available, appetizing, easy to digest, high-calorie foods.

I've seen the benefits of these drugs for people close to me but this whole concept still feels a bit dystopian. Companies selling $500-$1,000/mo drugs to counteract the garbage food and "food products" other companies are producing and marketing to us.

In a few years the pill versions will be $40/mo.

Re: FDA Approves Lilly's Zepbound (Tirzepatide) for Chronic Weight Management

#59

Post by aantix »

rs_rs_rs_rs_rs wrote: post #37
nathanyz wrote: post #16

Earlier quoted context omitted.

This cannot be understated. Obesity is being changed from a willpower problem to a chronic disease that is treatable. The follow-on effects of this are huge.

>Obesity is being changed from a willpower problem to a chronic disease that is treatable It's absolutely a willpower problem. These medications won't fix that for you. You stop taking them and you will gain weight again.

Long-term success numbers on 10-year weight loss are abysmal. Everyone gains it back.

Eating right, exercising, taking this medication - if you stop any of these, yes, you will gain back weight.

Re: FDA Approves Lilly's Zepbound (Tirzepatide) for Chronic Weight Management

#60

Post by chownie »

poopchute wrote: post #51
n8cpdx wrote: post #39

Earlier quoted context omitted.

It seems obvious but the “just eat less” crowd needs to hear it. Ever try working on a tricky coding project while starving? Take a math test when all you can think about is finding something, anything, to eat? Losing significant amounts of weight the natural way isn’t so much a test of willpower as a test of how well you can function under a constant sense of hunger (or, how good you are at tricking your way out of…

There are quite a few veggies that are low calorie, filling, and are tasty enough to snack on without dip. The ones I eat when I just want to feel full without a bunch of calories are carrots (45 cal/100g), cucumbers (14 cal/100g), sugar snap peas ( 42 cal/100g), and yellow bell pepper (27 cal/100g).

The caveat being that taste is subjective.

If we're talking raw with no sauce I can't say there's any vegetable I'm keen to snack on, certainly none on your list.

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