Scientists improve anti-tumor power of CAR-T cells • Hacker News Board

Post by starchild_3001 » Fri, Sep 29, 2023, 1:08 AM UTC

alexey-salmin wrote: post #30

starchild_3001 wrote: post #27

Earlier quoted context omitted.

Diet and exercise are universally failed interventions to stop major diseases (CVD, cancer...). People who have a vested interest in them promote them (e.g. exercise specialists, keto experts, vegan gurus, your favorite TV Dr, harvard nutrition dept whose livelihood depends on the effectiveness of "optimal diet" etc), but the results in intervention trials have been extremely disappointing. 1) The best diet studies w…

> Exercise is even worse. It has virtually zero effect on CVD outcomes, mortality outcomes in trials where participants were asked to change their behaviors. This is simply not true and you jump through some curious hoops to make it look credible. The paragraph you cite basically says "if you start after 60 it's too late". Is then proceeds to add that a few weeks of exercise are not enough, and a few months of follow…

This is biased reading at its worst. I was simply stating what the authors concluded based on their analysis of 10-20 studies (not just one). This is what they say in the abstract: "The results show that exercise does not reduce all-cause mortality and incident CVD in older adults or in people with chronic conditions, based on RCTs comprising ∼50,000 participants."

One study with 500 people doesn't prove a point.

Of the top of my head I know at least one other study where mid-life lifestyle intervention didn't reduce mortality (it slightly increased it in a statistically non-significant manner). 21 yrs follow up. ~3000 people. https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.0...