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Human embryo models grown from stem cells

wis-wander.weizmann.ac.il

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Re: Human embryo models grown from stem cells

#51

Post by stanford_labrat »

pvg wrote: post #46
stanford_labrat wrote: post #39

Edit: link to my previous comment with a list of papers from the last time a similar thread was posted for those interested. https://news.ycombinator.com/item?id=37018392 This was a busy summer for developmental biology, full disclosure that I am an author on one of these papers and my thesis work is in embryo models/early development. The Hanna group was unfortunately scooped by some unethical behavior but their mod…

Just link your old comment next time since sometimes threads get merged https://hn.algolia.com/?dateRange=all&page=0&prefix=true&que...

Thank you I wasn't aware, appreciate it.

Re: Human embryo models grown from stem cells

#52

Post by pizzafeelsright »

shadowgovt wrote: post #27
pizzafeelsright wrote: post #12

[flagged]

From an ethical standpoint, there is no reason to assert a human being created from re-embryonized adult stem cells should be any more enslaveable than any child of any parents or the younger of any pair of twins. ... of course, the flip-side of the coin is that for a certain segment of the pro-life movement, using these cells as test subjects will be equivalent to intentionally fertilizing human egg cells and then u…

Ethics have always been fungible when the hunger is strong.

My comment was mostly in jest.

Re: Human embryo models grown from stem cells

#54

Post by TeMPOraL »

abledon wrote: post #20

population collapse: solved {checkmark} warring super-solider arms race: {added to jira board}

Out of all sci-fi/fantasy ideas out there, I'd never have thought Star Wars: Attack of the Clones would show up as a possible future. But as we are making rapid advancements in robotics and AI on one hand, and biotech on the other, and the relevant fields are controlled by different corporate interests, clones fighting droids doesn't seem so out there anymore.

Re: Human embryo models grown from stem cells

#55

Post by jtbayly »

Retric wrote: post #45
jtbayly wrote: post #15

Earlier quoted context omitted.

>"For one thing human embryos would have already been implanted in a womb for a week at that point" At what point? Implantation typically occurs 6-12 days after fertilization. This experiment starts at the equivalent of day 7. IVF is a thing. It sounds like you're just guessing. Edited to add, this article says "It would be illegal to implant them into a patient’s womb" which is a far cry from what you are implying,…

I thought I was repeating what the article said: “This stage corresponds to day 7 of the natural human embryo, around the time it implants itself in the womb.” “The researchers discovered that if the embryo is not enveloped by placenta-forming cells in the right manner at day 3 of the protocol (corresponding to day 10 in natural embryonic development), its internal structures, such as the yolk sac, fail to properly d…

None of your quotes indicate that it would be impossible to implant these. The article is beating around the bush, but essentially it is saying "These could potentially be implanted." That's why people are somewhat up in arms about this. Read the other article I linked.

This research in animals has led to successful implantation, but not live births. Nobody knows why yet.

Re: Human embryo models grown from stem cells

#57

Post by Retric »

jtbayly wrote: post #55
Retric wrote: post #45

Earlier quoted context omitted.

I thought I was repeating what the article said: “This stage corresponds to day 7 of the natural human embryo, around the time it implants itself in the womb.” “The researchers discovered that if the embryo is not enveloped by placenta-forming cells in the right manner at day 3 of the protocol (corresponding to day 10 in natural embryonic development), its internal structures, such as the yolk sac, fail to properly d…

None of your quotes indicate that it would be impossible to implant these. The article is beating around the bush, but essentially it is saying "These could potentially be implanted." That's why people are somewhat up in arms about this. Read the other article I linked. This research in animals has led to successful implantation, but not live births. Nobody knows why yet.

Nothing I said had anything to do with if these were viable or could be made viable, just that they aren’t direct equivalents.

People could be up in arms if hypothetically 50% of these where viable, but the nonviable 50% would still cause errors when compared to human embryos. Alternatively, 100% could be viable and they could still be different in critical ways from natural human embryos resulting in universally late or premature births etc. Or perhaps 0% are viable and people just don’t understand the nuances.

It’s therefore an orthogonal question.

Re: Human embryo models grown from stem cells

#58

Post by areoform »

ed wrote: post #47
areoform wrote: post #41

Earlier quoted context omitted.

Would you be open to giving a talk on the topic?

Given the spectrum of talk opportunities you might want to provide a little context. There’s a big difference between eg “my twitter space” and Ted.

It would be indiscrete of me to say so. But always happy to chat privately! I can be reached on the username areoform via areoform.com

Re: Human embryo models grown from stem cells

#60

Post by thedailymail »

polski-g wrote: post #25

The hard part of children is the womb and available parents, not creating an embryo. The UK needs to finish their artificial womb work.

The lab that published this paper has also been developing an ex vivo environment for growing these kinds of human embryoids by what's called rolling culture. Other groups specializing in extremely premature neonatal care have been pushing the gestational envelope from the other direction.
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