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Metformin shown to prevent long Covid

cidrap.umn.edu

51–60 of 195 posts

Re: Metformin shown to prevent long Covid

#51
post #21

Earlier quoted context omitted.

It's continuous. Mean make sperm constantly, and the sperm die constantly. What the study shows is that if there's an effect it would have to be in the short time between the sperm developing and dying

TL; DR Do not take if you're trying to impregnate someone. (Is that the right term? Get pregnant?)

"impregnate" is not wrong per-se, but it is weird in placing the emphasis on only one of the two people required. Usually you'd say something like "trying for a child", I believe.

Re: Metformin shown to prevent long Covid

#52
>Now that we're in 2023, and pretty much everyone is either multiply-vaccinated or has had COVID

I'm a facilitator for a men's mental health talking group in my county. Sample size is small and not indicative, but there are a few people who are anti-vaccination, have continued to eschew popular science in favour of their trusted researchers, and are now assigning blame to almost any other person's illnesses as caused by "the vaccine".

Edit: I'm getting downvoted, so I should clarify -- I'm not agreeing with this person at all, I'm vaccinated and boosted.

Aside: one of the (anti-vaccination, anti-establishment) attendees has said that his (anti-vaccination, anti-establishment) trusted expert told him "the banks will collapse" on June 27th (he mentioned Santander specifically). So, now you know.

Re: Metformin shown to prevent long Covid

#55

Does it help those with long Covid?

Only in obese and overweight patients (that is the group the drug was tested on).

And yet they have the clickbait headline. Overweight and obese people already have their body in a constant state of inflammation, and their blood sugar control probably isn't great either. I wonder if they controlled for insulin resistance and prediabetes, which is related to obesity.

Re: Metformin shown to prevent long Covid

#56

TLDR: > By day 300 of follow-up, 93 (8.3%) of 1,126 participants said they had received a diagnosis of long COVID by a provider. The cumulative incidence of long COVID by day 300 in those who took a 14-day course of metformin was 6.3% (95% confidence interval [CI], 4.2 to 8.2) compared to 10.4% (7.8 to 12.9) in the placebo group, or 39.4% lower. Interestingly, half of the participants in the study (which took place s…

It was also tested only in overweight and obese patients. Pretty much most people are overweight and obese in the US as well, I wouldn't draw any results from this study for people at normal weight.

Re: Metformin shown to prevent long Covid

#57

>Now that we're in 2023, and pretty much everyone is either multiply-vaccinated or has had COVID I'm a facilitator for a men's mental health talking group in my county. Sample size is small and not indicative, but there are a few people who are anti-vaccination, have continued to eschew popular science in favour of their trusted researchers, and are now assigning blame to almost any other person's illnesses as caused…

Well, I developed heart problems just after getting vaccinated so it's pretty hard for me not to agree when people speculate that some sudden death, severe illness or whatever at a young age may be due to the vaccination. I know I am biased, but how can I not be?

Re: Metformin shown to prevent long Covid

#59
post #46

Earlier quoted context omitted.

I think you're misinterpreting it. The full quote: > Long Covid is looking less like a cloudy mass of speculation and shoulder-shrugging, and more like a problem that medical science can start to unravel, using the tools we already have: > When a disease is too poorly defined, it follows that it is almost impossible to modify either the incidence of that disease or the distribution of its outcomes—that is, unless the…

You’re not paying attention if you think this is the first evidence of long covid. There’s been significant strides towards understanding long covid in terms of microclots and viral persistence. https://cardiab.biomedcentral.com/articles/10.1186/s12933-02... For this pathology long covid can be treated with so called triple therapy for instance https://medhelpclinics.com/uploads/files/anticoagulant-tripl...

And, recently discovered too, inflammation-induced neuron mergings.

Re: Metformin shown to prevent long Covid

#60

>Now that we're in 2023, and pretty much everyone is either multiply-vaccinated or has had COVID I'm a facilitator for a men's mental health talking group in my county. Sample size is small and not indicative, but there are a few people who are anti-vaccination, have continued to eschew popular science in favour of their trusted researchers, and are now assigning blame to almost any other person's illnesses as caused…

Well, I developed heart problems just after getting vaccinated so it's pretty hard for me not to agree when people speculate that some sudden death, severe illness or whatever at a young age may be due to the vaccination. I know I am biased, but how can I not be?

Firstly, I'm sorry you've developed heart problems. That sucks. I can't imagine how that feels in real life, but I can fully understand how it changes your perspective on a lot of stuff.

I should further clarify. My original comment was referring to a person who was saying, essentially, that if a person had been vaccinated, then any subsequent illness was a direct cause of the vaccine. His take was that any pre-existing condition was made worse, and the root cause of any kind of ailment was the Covid vaccine. Black & white, no room for discussion.

I can see how my comment could be misinterpreted in a number of ways. I don't subscribe to his stance, but I'm absolutely open to the increasing body of evidence of post-vaccine and post-Covid medical issues that have and continue to arise. I have a friend who was a whip-smart and highly capable gastric surgeon. She was fully vaccinated, then got Covid (positive tests), now has many symptoms of long Covid, and she's medically retired at 34. She has to have 10 minute snoozes every 30 minutes during the day. No diagnosed pre-existing conditions, she was in tip-top health.

I have absolutely no pro- or anti- agenda here, I was merely sharing some anecdotal evidence.

Most importantly, I hope you can find your way with your health stuff.

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