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Time-restricted eating reshapes gene expression throughout the body

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51–60 of 97 posts

Re: Time-restricted eating reshapes gene expression throughout the body

#51

I tried this. Ended up thinking about food too much until 1 pm. But I might try it again.

Best trick IMO is to take prebiotic fiber while fasting.

That way your gut bacteria gets fed and doesn’t get desperate to tell your brain you’re starving.

Personally I don’t feel ketogenic state is reached from 16 hours. Feels like I need at least 24 hours, but usually do 36. Only thing I need other than water is electrolytes. I would get bad headaches without my mineral/pink salt.

Re: Time-restricted eating reshapes gene expression throughout the body

#52
post #48

Earlier quoted context omitted.

Your theory is that we don't know anything about the biological similarities and differences between humans and the animal most studied, one picked because it has a lot of biological similarities? That seems like quite a stretch. I mean yes, people should not just assume that it will be the same. But as with a lot of studies in mice, it can inform what we study further in humans.

No, that is not my theory. How similar is 16:8 for mice and humans? That’s all we are discussing here and all I’ve talked about! I’ve reread my comments and I really can’t see where I start talking about all biological similarities or not. I’m talking specifically about 16:8 fasting. Can you tell me how similar humans and mice are in this regard?

Ok, so your theory is that even though we study mice because the are in many ways good proxies for humans, there's some special exception when it comes to fasting?

Yes, we don't yet know precisely how similar humans and mice are in this regard, because studies in mice generally precede doing the matching study in humans. But that doesn't mean we should assume that there's absolutely no correlation.

And yes, the more general biological similarities are relevant here because you claim "we simply do not know how to do that mapping", and that's not the case. We can't do a perfect mapping because mice aren't humans, but we can make a good start. We broadly know quite a bit about the relationship between mice and men and what sorts of correlations are more and less likely. E.g., if the study were about fitting through small holes, we'd know that the study wouldn't tell us much about humans. But we use mice because of "their anatomical, physiological, and genetic similarity to humans". [1]

Does that mean people should take this as gospel about what happens in humans? No. But it gives us a lot of good questions and things to explore in humans.

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987984/

Re: Time-restricted eating reshapes gene expression throughout the body

#53

Earlier quoted context omitted.

Presuming you read the linked study but more or less (and this is argument fuel among The Faithful here ), "time restricted eating" spoken of here is Intermittent Fasting. The "restriction" here is that not a single calorie of anything is consumed outside of an 8 hour window and the 16 remaining hours in the day are nothing but water. Some people even like to do a 18:6 split too. The hacks in this style of eating is…

> EDIT: For extra credit - it's natural to look at Fasted Training in the same context. The hack here is that when you train at near peak low insulin levels ( or near peak anyhow which takes about 14h of fasting ) your body will suffer in terms of absolute performance but if done correctly you can train burning mostly fat. Theres as much on this subject to sort through as the first one. A whole host of hormonal and h…

> I've done quite a bit of fasted training, but can't say I have seen a huge effect myself

I've tried it and haven't seen much of a difference in weight loss either. Also I have only been able to pull it off with cardio - any fasted training involving weight lifting has been a dreadful experience. I've completely abandoned the idea.

Re: Time-restricted eating reshapes gene expression throughout the body

#54
post #14

I’ve been doing intermittent fasting for 2 years. Did a bunch of different protocols and eventually settled on ~18:6. Lost around 15kgs (from 105 to 90) and as a nice “side effect” got rid of all skin problems that I’d had during the previous 10 years or so. Today I don’t preach it anymore cause I got tired of debating whether it was healthy or not but I definitely recommend to everyone that’s truly interested in giv…

I tried it for some time but felt cranky in the morning until I ate at lunch time. How was your experience regarding cravings, hunger and mood changes over time when starting your fasting?

I was a religious breakfast eater. Would often wake up because I was hungry. The first few weeks of IF was rough, but the hunger eventually passed. My energy levels also dipped, but then went way up. I try to do all my deep work and exercise before my first feeding of the day because of how sharp I feel.

3ish years in I feel great, and routinely get comments how 'in shape' I look. I also try to weight train every day and train BJJ a few times/week.

Other things I've learned personally is if I eat poorly the night before (lots of sweets or something), I am more likely to feel a bit of hunger the next morning. Normally I don't really feel hungry though, and if I'm busy I can go right through lunch without noticing.

Re: Time-restricted eating reshapes gene expression throughout the body

#55
post #37

Earlier quoted context omitted.

In my experience, it's exceptional in America. This may be due to constant indoctrination that "breakfast is the most important meal of the day". Also, modern food processing has put all sorts of late-night snacks at our fingertips.

Hard to imagine skipping breakfast, lunch, coffee/tea w/milk & cream, and all snacking during the day, everyday is normal outside America. Isn't burned bread with beans or butter for breakfast a thing in the UK? 16:8 means if your last calories are before 10PM, you wouldn't eat anything at all until after 2 PM. And this would be every day, not every other day. 12:12 might be more common, but not consistently.

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Re: Time-restricted eating reshapes gene expression throughout the body

#56

Earlier quoted context omitted.

In my experience, it's exceptional in America. This may be due to constant indoctrination that "breakfast is the most important meal of the day". Also, modern food processing has put all sorts of late-night snacks at our fingertips.

Agreed. 16:8 is not normal in America in 2023. Most people pay absolutely no attention to when they eat - only what they eat.

Given the amount of disagreement, I'd expect it is common enough but with some multimodal distribution tied to culture, geography or job type, so that the two modes don't notice each other. Happens with lots of stuff. My N=1 is that I probably know fewer people who skip breakfast (to include calories in coffee) than I do people who do 20:4 fasting. I like how I felt on 20:4 but it is easy to fall off of for social reasons, and womce I do, the blood sugar related cravings come back so I need a 48H water fast to get back into effortless 20:4.

Re: Time-restricted eating reshapes gene expression throughout the body

#57
post #14

I’ve been doing intermittent fasting for 2 years. Did a bunch of different protocols and eventually settled on ~18:6. Lost around 15kgs (from 105 to 90) and as a nice “side effect” got rid of all skin problems that I’d had during the previous 10 years or so. Today I don’t preach it anymore cause I got tired of debating whether it was healthy or not but I definitely recommend to everyone that’s truly interested in giv…

I tried it for some time but felt cranky in the morning until I ate at lunch time. How was your experience regarding cravings, hunger and mood changes over time when starting your fasting?

I only had cravings while doing the 36 hours fasting, which I don’t do regularly anymore. It was usually during dinner time (rest of the family was having dinner normally) and what I tried to do was to distract myself with something else (work, book, movie, etc.). I never really had problems during other periods of the day.

What I’d suggest is to experiment a bit, perhaps in your case skipping dinner is easier than skipping breakfast. Or try to start by simply not having snacks and gradually increase the intervals between meals.

Re: Time-restricted eating reshapes gene expression throughout the body

#58
post #12
post #4

Notes: - In mice. - Tested 16:8 pattern. - Sustained consistently for nine weeks. - No exploration in this study of the effects and/or benefits from the gene expression. N=1 but I've been doing ~16:8-ish along with strict keto for the past five years and the net benefits for me have been transformative in fitness (Weight: -100+ lbs, BMI: Obese->Fit), long-term health (A1C, LDL/HDL, Trigs, BP, resting heart rate all f…

I had similar improvements without fasting and without keto. I do 16:8 on some days but it's mostly to help me manage my weight. I strongly believe most of the fasting benefits come from the fact that it makes managing weight easier. Calorie restriction and tracking my macros has helped me tremendously not only loosing weight but also understanding nutrition and what works for me and what doesn't. I am a 40 year old…

For me the benefits seem to be a lack of carb cravings, and my fullness indicator turned on for the first time in my life. That was with 20:4 though, and no keto.

Re: Time-restricted eating reshapes gene expression throughout the body

#59
post #52

Earlier quoted context omitted.

No, that is not my theory. How similar is 16:8 for mice and humans? That’s all we are discussing here and all I’ve talked about! I’ve reread my comments and I really can’t see where I start talking about all biological similarities or not. I’m talking specifically about 16:8 fasting. Can you tell me how similar humans and mice are in this regard?

Ok, so your theory is that even though we study mice because the are in many ways good proxies for humans, there's some special exception when it comes to fasting? Yes, we don't yet know precisely how similar humans and mice are in this regard, because studies in mice generally precede doing the matching study in humans. But that doesn't mean we should assume that there's absolutely no correlation. And yes, the more…

[deleted]

Re: Time-restricted eating reshapes gene expression throughout the body

#60
post #4

Notes: - In mice. - Tested 16:8 pattern. - Sustained consistently for nine weeks. - No exploration in this study of the effects and/or benefits from the gene expression. N=1 but I've been doing ~16:8-ish along with strict keto for the past five years and the net benefits for me have been transformative in fitness (Weight: -100+ lbs, BMI: Obese->Fit), long-term health (A1C, LDL/HDL, Trigs, BP, resting heart rate all f…

16:8 is utterly unremarkable. A huge percent of people skip breakfast and then have dinner before 8pm. This is a normal, bog standard eating pattern.

If you mean a full meal, sure. However, I suspect the majority of people enjoy some calories pretty early in the day. Sugary coffee/tea, cereal bar, bagels or other grab and go snacks.
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