51–57 of 57 posts
Earlier quoted context omitted.
YC 2043: Aging as a service. AaaS.
I mean ... they literally talk about the potential ability to force the aging process backward or forward in the abstract, so... haha.
Earlier quoted context omitted.
Sure, but "ageing is a result of increasing entropy" is pretty much the same as saying that ageing is caused by the passage of time. The interesting part here is that they narrow down which loss of information is important.
Increasing entropy in a system can be avoided with an external energy source.
If they manage to slow down aging in the next few years, and 80 becomes the new 70s or whatever, this country will explode.
Earlier quoted context omitted.
Who says you want more robust DNA transfer? I can imagine there was a time before the LUCA where life was a competition between these gene transfer mechanisms. DNA exists for a reason imo, gene mutation is a feature not a bug
For the species yes, for the individual I don't know that the math is that settled.
Also, the number of mutations that are actively beneficial are lowish. Even on the level of a single human, the whole organism prefers its genes stay intact.
Evolution doesn't work on the species level.
Is this applicable in any therapeutic sense?
Randomized clinical trials are not as golden a standard as they seem and methodologically they are designed for human cattle, who do not choose what to consume and do not care to read a Wikipedia page or more about the drug they're taking or its target receptors they have, let alone any research on it. Thus, in an instruction label for an approved drug you'll see dozens of adverse effects, established in randomized clinical trials, yet close to zero information about the probability of you personally being affected by these adverse effects.
Likewise, there are ~thousands of "biohackers" taking the safe metformin off-label, for "anti-aging" purposes. And any interested individual can choose an experimental treatment, taking all the risks etc.
As per Hippocrates Oath [1]: 1) I swear to fulfill, to the best of my ability and judgment, this covenant: 2) I will apply, for the benefit of the sick, all measures [that] are required 3) I will prevent disease whenever I can, for prevention is preferable to cure.
How would you ensure a physician is employing the best of their ability? By their brain oxygenation level? Or dopamine receptors occupancy in prefrontal "executive" cortex? Thus ~90% of physicians regularly violate at least 2) and 3) statements of the oath, by not offering the possible experimental treatments in relevant sets&settings.
Earlier quoted context omitted.
Sure, but "ageing is a result of increasing entropy" is pretty much the same as saying that ageing is caused by the passage of time. The interesting part here is that they narrow down which loss of information is important.
Increasing entropy in a system can be avoided with an external energy source.
There was a study probably cited by Sinclair in his Lifespan book with mice genetically engineered to have 0.5-1 degree less than normal body temperature. And they lived like ~30% or more longer.
Such hypergeneralised physical thought inevitably leads to necrology in the end-point measurements, rather than biology.