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In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

nature.com

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Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#51

Am I the only one who thinks immortality is a nightmare? I don't understand people who want to live forever.

Altered Carbon, and to a lesser extend Upload! touch on this dystopian part - the great leveller is that every billionaire will one day die - imagine if that wasn't the case, and they could keep hoarding wealth and having undue political influence.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#52

Earlier quoted context omitted.

Anti-aging effects in mice*

We've got to be careful or we're going to end up with super-intelligent immortal mice!

Super intelligent, immortal, and free of cancer, diabetes, Alzheimer, and MS.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#54

Am I the only one who thinks immortality is a nightmare? I don't understand people who want to live forever.

I can't help but feel there is an element of self-justification in that sort of view.

We can't stop death, therefore we tell ourselves its ok and something that we actually want, in order to cope with the terror of death.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#55

Am I the only one who thinks immortality is a nightmare? I don't understand people who want to live forever.

Altered Carbon, and to a lesser extend Upload! touch on this dystopian part - the great leveller is that every billionaire will one day die - imagine if that wasn't the case, and they could keep hoarding wealth and having undue political influence.

Would you really want your parents to die, your loved ones, your family, your children, and yourself, all so you could have the satisfaction that at least rich people, and their loved ones, would suffer and die too?

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#56

Am I the only one who thinks immortality is a nightmare? I don't understand people who want to live forever.

HN is the only place where I’ve seen people purpose immortality as a legit goal. I think it’s because of lack of religion. If you are existentially scared of death and you are a techie, it makes sense

Immortality is literally the carrot that religion holds in front of its followers.

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#57

Quoted post unavailable.

1) There is no "epigenetic clock theory". There is an epigenetic clock though, and it's a well established system[0]. They are talking about measuring a cellular "age" by measuring the methylation/acetylation tags on DNA and histones. These tags are essential for specialized cellular function and a core part of Horvath's/Sinclair's "epigenetic theory of aging".

2) Sinclair is not a quack, and to depict him as such doesn't help whatever opinion you're parroting. The guy has quite the resume, and obviously playing the social media game doesn't mean you should dismiss that.

3) Linking a tweet that essentially says "no you're wrong" is adding to the noise and isn't helpful. Brenner is saying reversing epigenetic age isn't going to make you immortal, which is true. It doesn't mean Sinclair's work is BS.

[0] https://en.wikipedia.org/wiki/Epigenetic_clock

Re: In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’ (2019)

#59

I’m no fan of death, but death (by natural causes - age, sickness , accident) has been how different generations have gotten rid some of the worst despots.

“The hate of men will pass and dictators die. And the power they took from the people will return to the people. And so long as men die, liberty will never perish."
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