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Fasting boosts stem cells’ regenerative capacity (2018)

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Re: Fasting boosts stem cells’ regenerative capacity (2018)

#51
post #12

Earlier quoted context omitted.

And good for getting rid of lean body mass...

Completely incorrect. Time-restricted eating and concurrent exercise training reduces fat mass and increases lean mass in overweight and obese adults https://pubmed.ncbi.nlm.nih.gov/34042299/

Agree. I notice zero lean body mass loss while fasting.

At least no more than I would just sitting on the couch doing nothing.

Re: Fasting boosts stem cells’ regenerative capacity (2018)

#52
post #39

Earlier quoted context omitted.

Wait what? English is not my native language, are you saying you didn't eat any food for 30 consecutive days??

60 days as I understood - first 30 days just water and then the next 30 days water with electrolytes

Correct. Which, for the record, I would never repeat and wasn't what I now consider safe.

Electrolyte supplementation on an extended fast is important, and I drank way _way_ too much water in the early weeks of that fast, which is also dangerous.

Re: Fasting boosts stem cells’ regenerative capacity (2018)

#53
post #21
post #16

Earlier quoted context omitted.

Fasting is not malnutrition. A typical human even lean one has enough fat to survive without food for 30-40 days without significant loss of lean mass. This sets us quite apart of other animals including apes. One starts to loose lean mass during prolonged calorie deficit which takes months.

But in clinical trials they found that even intermittent fasting leads to LBM loss. > https://www.hawaii.edu/news/2020/10/09/intermittent-fasting-... Considering Body Builders don’t fast, I tend to believe the study.

> The study only included recommendations to the timing of food intake and did not provide recommendations for calorie and macronutrient intake or physical activity.

> 116 overweight and obese participants

Yeah I mean IF isn't magic. If you sit in front of netflix and eat three 800cal bags of chips it doesn't matter much if you're doing IF or not.

I'm doing IF for years and go to the gym every other day, most of the time fasted. I made good progress, lost fat, gained muscles, and most importantly I feel amazing.

Eating schedule is only a part of the equation. You still need to eat proper food and exercise.

Re: Fasting boosts stem cells’ regenerative capacity (2018)

#54

Earlier quoted context omitted.

>Maybe body builders lose lean body mass when they fast Well, highly fit people certainly lose lean body mass when they fast, which you're probably not (even if you're fairly fit) And bodybuilders DON'T lose fat when they fast because they take supraphysiological doses of hormones (steroids) that prevent the body losing muscle - and usually eat protein throughout their fast too. So not a good example.

> eat protein throughout their fast too Aren't these contradictory? If you eat (protein or otherwise) you're not fasting.

I think they misspoke and what they meant to say was that bodybuilders use a zero/low carb diet, in which case their statement holds true.

Re: Fasting boosts stem cells’ regenerative capacity (2018)

#55
post #22

It's such a shame that there isn't more research in this area. There are so many seemingly wondrous effects on human health that would need thourugh testing. Apart from physiological benefits though, the mental aspect of fasting from my own experience can be quite exciting as well. A 7 day fast was the longest I did so far, but 72h really hit the sweet spot for me. It was like a journey through my mind, I got challen…

I really think a 7 day fast should be 'mandatory reading' as far as life experience goes. You learn a lot about yourself. Also echo the mental clarity side of fasting. The weight loss was great, but how I felt was even better. The crazy thing is, if you can get to 7 days, anything past that is just mental and you can go as long as you have the body fat to sustain the fast, provided you're keeping an eye on your elect…

I'm not sure if starting something like a 7-day fast without medical supervision is a good idea, and I'm also not sure if any medical professional would allow you to do that, just thinking out loud.

Don't you think it's too dangerous to name it essential life experience and recommend it to random people on the internet?

I'm really asking, I'm not knowledgeable about this at all, and my questions stem from pure gut feeling.

Re: Fasting boosts stem cells’ regenerative capacity (2018)

#56
post #35
post #16

Earlier quoted context omitted.

Fasting is not malnutrition. A typical human even lean one has enough fat to survive without food for 30-40 days without significant loss of lean mass. This sets us quite apart of other animals including apes. One starts to loose lean mass during prolonged calorie deficit which takes months.

As I understand it, based on books such as Faster[1] by Michael Hutchinson, it depends on the intensity of what you do. At low intensity exercise you can just burn just fat. The body can only get so much energy from fat in a given time, so at higher intensity levels it will try to get energy from both fat and stored carbohydrates. Once you run out of easily available carbs it will try to supplement energy from the ne…

This is actually my understanding of it as well, though I kind of arrived at the conclusion on my own pulling from various sources and experience.

People think about fat as if they have access to it all, but it's a surface area per unit time problem. Like all the chemistry in life, on some level, it's diffusion limited.

What you should be thinking about while fasting is not letting your basal rate/time + exercise expenditure/time exceed your total energy available/time. I got pretty good at estimating this, but I wish there were an easy way to measure it.

Everything is stream processing, not discrete units.

Re: Fasting boosts stem cells’ regenerative capacity (2018)

#57

One more reason to become Muslim.

Imagine not being able to single out fasting and doing it without getting yourself into a religion. What other things can you not single out and need to delegate the thinking to religion for I wonder?

They were just making a joke.

Re: Fasting boosts stem cells’ regenerative capacity (2018)

#58
post #39

Earlier quoted context omitted.

60 days as I understood - first 30 days just water and then the next 30 days water with electrolytes

This guy should be dead, his body should have digested himself. How can someone not eat anything by his own will for more than a few days ? (5-7 max) you should pass out. Also in the case that were true, let me be clear: No food intake for multiple days is extremely dangerous for your health, it will upregulate autophagy, apoptosis and will break your mitochondria bioenegetics which will explode your oxidative stress…

18days here and would carried on but had to break it for other reasons.

Glutathione possibly needs to be included as this will get low and Choline or Carnitine to remove the brain fog that occurred.

Averaged 18kg weight loss over the 18days, never felt so good in my life, like being a teenage male ramped up on Testosterone again, amazingly easy to fall asleep, excellent quality of sleep, vivid dreams which are recalled in the morning, not nightmares or anything like that. Foods which I dont like because of historical reasons smelt appealing and I wanted to eat them, no cravings for anything.

The only water I could really wanted, was the Scottish Highlands water, just didnt like Evian, S. Pellegrino, and the supermarket brands, and I wonder if highly filtered water ie dead water with no contaminants so its almost pure H2O would have been what I wanted, but they dont sell that in supermarkets AFAIK.

Ramadan is one of the fasts where you dont consume fluids during the day, and not consuming fluids will ramp up parts of your immune system which is why its important to drink fluid in order to not get angry. This could be in part because histamine is used by immune cells to move through tissues, but a personality side effect of high amounts is increased aggression. Anyone who supplements with histidine a precursor for histamine may also notice increased aggression. ie explosive rage, so be careful.

Re: Fasting boosts stem cells’ regenerative capacity (2018)

#59

Earlier quoted context omitted.

I really think a 7 day fast should be 'mandatory reading' as far as life experience goes. You learn a lot about yourself. Also echo the mental clarity side of fasting. The weight loss was great, but how I felt was even better. The crazy thing is, if you can get to 7 days, anything past that is just mental and you can go as long as you have the body fat to sustain the fast, provided you're keeping an eye on your elect…

I'm not sure if starting something like a 7-day fast without medical supervision is a good idea, and I'm also not sure if any medical professional would allow you to do that, just thinking out loud. Don't you think it's too dangerous to name it essential life experience and recommend it to random people on the internet? I'm really asking, I'm not knowledgeable about this at all, and my questions stem from pure gut fe…

I also question if 7 days is safe for most. I don't recall exactly when and a quick search now yields a lot of random gimmicky fasting product sales sites with blog posts written to generate traffic that aren't scientific enough, but I do recall that there is a point (after 72 hours?) where your body starts breaking down muscle and that prolonged fasting is dangerous as your organs get hit next?

Perhaps someone here with medical experience can chime in, but I agree 7 days seems a bit extreme for most people.

Re: Fasting boosts stem cells’ regenerative capacity (2018)

#60
post #50

Earlier quoted context omitted.

This guy should be dead, his body should have digested himself. How can someone not eat anything by his own will for more than a few days ? (5-7 max) you should pass out. Also in the case that were true, let me be clear: No food intake for multiple days is extremely dangerous for your health, it will upregulate autophagy, apoptosis and will break your mitochondria bioenegetics which will explode your oxidative stress…

That's not how it works at all. Not drinking water will damage/kill you real fast, not eating food on the other hand is pretty safe for most people. The longest fast was ~380 days [0] If you have some fat (75% of westerners are heavily overweight or obese) you can easily fast on water only for weeks, of course you're not going to be able to exercise heavily every day or run a marathon. But if you're an overweight off…

1) there are tons of substances the body can't make out of nothing/lipids. 2) there are tons of substances the body can't make efficiently with no food, which leads to metabolism/health deficits. and no it's not just vitamins and electrolytes LOL it's much more complex and diverse than that.

3) even if we assume in an ideal world, that the person who fast is able to supplement ALL the useful things and yet not take any external calories/glucose. This person would still reach a huge bioenergetic deficit/stress. Yes he will survive as you say, and might even be asymptomatic but nonetheless I would be very surprised if the biomarkers where doing Okay. Default bloodworks analysises are shit but if you command a proper analysis of your antioxidants ratio and of your bioenergetics biomarkers and apoptotic biomarkers you will see (unless I'm wrong which is very unlikely given my expertise) that the body is having a significantly accelerated aging/damage scheme. Which might not show symptoms before multiple decades later and even might not show symptoms at all in his life but statistically, there is a risk. Now he can mitigate some of those, by taking e.g. ALCAR + NAC daily for a year.

BTW the guy you linked died at 50 years old, which is not a performance.

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