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Breakthrough Cases May Be a Bigger Problem Than You’ve Been Told

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Re: Breakthrough Cases May Be a Bigger Problem Than You’ve Been Told

#51

Earlier quoted context omitted.

> He's right in a way, being vaccinated keeps you out of hospital, but it won't prevent you that much from catching the disease and developing post-covid syndrome This is misinformation. From the data we have available, vaccination prevents at least 80% of symptomatic infections with the Delta variant. To characterize an 80% reduction in risk as “not that much” is simply trying to get people to give up on vaccines.

You see papers claiming an effectiveness against symptomatic infection against Delta of ~ 50 %, and the rise of cases in Israel as well as the Provincetown outbreak should really make us concerned. The vaccine still prevents hospitalization and death, so that's reason enough to take it. But on its own it isn't enough to get R_0 below 1. The way everyone is behaving, they are asking for outbreak after outbreak.

Yes, it’s at 47% now if I’m up to date.

Re: Breakthrough Cases May Be a Bigger Problem Than You’ve Been Told

#52
post #36

Earlier quoted context omitted.

Death, in the case of some younger (mostly women) people and the AZ vaccine. Canada and other countries literally don't use it for the reason, I believe the US hasn't certified it either. The Pfizer vaccine has been linked to some heart issues but mostly minor and with far less frequency. (For the record, I got Pfizer)

You realize that everything is a probability right? There are people who choke and die on Hot Dogs every year. So there is a "risk of death from hot dogs" Yet most reasonable people would not really care.

The same argument can be made for Covid itself too and is also an anti-vaxx argument. Everything we do has risks and we determine whether or not they're reasonable.

With vaccines, enough countries have said some have acceptable risk profiles (Pfizer and Moderna) and some are too risky (AstraZeneca).

Re: Breakthrough Cases May Be a Bigger Problem Than You’ve Been Told

#53
post #49
post #40

Earlier quoted context omitted.

I think he meant to ask about rates. The term risk is slightly ambiguous. Death or long term disability is the risk of Covid. The rates of those outcomes are extremely higher for the actual disease. I Feel like a lot of people are falling into a “Both sides” or “fair and balanced” type trap by over indexing on that in theory the outcome could be the same, while ignoring the elephant in the room that the odds are vast…

> The rates of those outcomes are extremely higher for the actual disease. But the risk of catching the disease is less than 100%. So you need to weigh the risk of the vaccine versus your risk of catching the disease AND dying. Do the probability of negative outcomes of AZ for women 20-40 versus the probability of catching Covid during a given timeframe AND dying for that same age group. There's a reason many countri…

In the long run everyone's risk of catching the virus is close to 100%. It's now endemic (like several other coronaviruses) and no matter what you do you can't expect to avoid exposure forever. Just a question of when.

Re: Breakthrough Cases May Be a Bigger Problem Than You’ve Been Told

#54

Earlier quoted context omitted.

You see papers claiming an effectiveness against symptomatic infection against Delta of ~ 50 %, and the rise of cases in Israel as well as the Provincetown outbreak should really make us concerned. The vaccine still prevents hospitalization and death, so that's reason enough to take it. But on its own it isn't enough to get R_0 below 1. The way everyone is behaving, they are asking for outbreak after outbreak.

Yes, it’s at 47% now if I’m up to date.

Wasn't it up around 75% in Providence RI? Yes, an outlier but it's indicative of the potential.

Re: Breakthrough Cases May Be a Bigger Problem Than You’ve Been Told

#55

Earlier quoted context omitted.

Yes, it’s at 47% now if I’m up to date.

Wasn't it up around 75% in Providence RI? Yes, an outlier but it's indicative of the potential.

Guess it’s 42% for Pfizer according to this preprint.[1] That’s July, so presumably even lower now. I thought I saw 47% somewhere more official but can’t find it now.

[1]https://www.medrxiv.org/content/10.1101/2021.08.06.21261707v...

“ However, in July, the effectiveness against infection was considerably lower for mRNA-1273 (76%, 95% CI: 58-87%) with an even more pronounced reduction in effectiveness for BNT162b2 (42%, 95% CI: 13-62%).”

Re: Breakthrough Cases May Be a Bigger Problem Than You’ve Been Told

#56
post #21
post #19

Earlier quoted context omitted.

The science on this is clear, please update your stance. Natural immunity is not as protective as vaccine induced immunity. It is in fact 2.3x more likely that you will get reinfected while unvaccinated, and a stronger immune response from the vaccine means fewer people end up hospitalized. See: > Reduced Risk of Reinfection with SARS-CoV-2 After COVID-19 Vaccination https://www.cdc.gov/mmwr/volumes/70/wr/mm7032e1.ht…

From your link: > these findings cannot be used to infer causation Do you have more data to support your claims?

Previous time that "Natural immunity vs vaccine induced immunity", and vaccinating after COVID was mentioned on HN:

https://news.ycombinator.com/item?id=28107854

tl;dr get the jab

Re: Breakthrough Cases May Be a Bigger Problem Than You’ve Been Told

#57
post #19

Earlier quoted context omitted.

The science on this is clear, please update your stance. Natural immunity is not as protective as vaccine induced immunity. It is in fact 2.3x more likely that you will get reinfected while unvaccinated, and a stronger immune response from the vaccine means fewer people end up hospitalized. See: > Reduced Risk of Reinfection with SARS-CoV-2 After COVID-19 Vaccination https://www.cdc.gov/mmwr/volumes/70/wr/mm7032e1.ht…

The reason for this global effort was because SARS-CoV2 was overrunning healthcare systems. The CDC also said: > Among the 469 cases in Massachusetts residents, 346 (74%) occurred in persons who were fully vaccinated > Among five COVID-19 patients who were hospitalized, four were fully vaccinated In other words, 80% of infections that require hospitalization are from vaccinated patients. https://www.cdc.gov/mmwr/volu…

> In other words, 80% of infections that require hospitalization are from vaccinated patients.

That means nothing unless you also know what percentage of the population are vaccinated.

Since you're interest in this topic, I'm sure that you have seen this graphic before:

https://twitter.com/jburnmurdoch/status/1418952126244478977

https://i.redd.it/km870p4xn1d71.jpg

Originally from the Financial Times of London, sorry i haven't soured it there, they have a paywall.

Let's not misrepresent incomplete data.

Re: Breakthrough Cases May Be a Bigger Problem Than You’ve Been Told

#58
post #19

Earlier quoted context omitted.

The science on this is clear, please update your stance. Natural immunity is not as protective as vaccine induced immunity. It is in fact 2.3x more likely that you will get reinfected while unvaccinated, and a stronger immune response from the vaccine means fewer people end up hospitalized. See: > Reduced Risk of Reinfection with SARS-CoV-2 After COVID-19 Vaccination https://www.cdc.gov/mmwr/volumes/70/wr/mm7032e1.ht…

> The science on this is clear, please update your stance. You are conflating science with "stats". > Natural immunity is not as protective as vaccine induced immunity. If that is true and if the science is clear, then why is that the case? What is the biological mechanism behind that? Shouldn't natural immunity be better in most cases since your body is actually fighting the real disease? Since you say the "science…

> Shouldn't natural immunity be better in most cases since your body is actually fighting the real disease?

And why should that be? Because natural is always better? See https://en.wikipedia.org/wiki/Naturalistic_fallacy

Vaccines produce a different and sometimes stronger response than the disease that they mimic, as they are literally designed to do.

In answer to your question: no, there is no "should" about it at all. it could go either way. And when it goes the wrong way, people try to redesign the vaccines until it goes the other way.

There is some evidence that COVID vaccines produce stronger responses. Links upthread.

> You literally spread FUD and misinformation

Please check yourself before flinging that accusation.

Re: Breakthrough Cases May Be a Bigger Problem Than You’ve Been Told

#59
post #52

Earlier quoted context omitted.

You realize that everything is a probability right? There are people who choke and die on Hot Dogs every year. So there is a "risk of death from hot dogs" Yet most reasonable people would not really care.

The same argument can be made for Covid itself too and is also an anti-vaxx argument. Everything we do has risks and we determine whether or not they're reasonable. With vaccines, enough countries have said some have acceptable risk profiles (Pfizer and Moderna) and some are too risky (AstraZeneca).

Not at all actually. Since the statistical evidence shows covid "bad-effects" at a rate much much higher than vaccine "bad-effects".

So basically your entire argument is wrong.

Re: Breakthrough Cases May Be a Bigger Problem Than You’ve Been Told

#60
post #52

Earlier quoted context omitted.

The same argument can be made for Covid itself too and is also an anti-vaxx argument. Everything we do has risks and we determine whether or not they're reasonable. With vaccines, enough countries have said some have acceptable risk profiles (Pfizer and Moderna) and some are too risky (AstraZeneca).

Not at all actually. Since the statistical evidence shows covid "bad-effects" at a rate much much higher than vaccine "bad-effects". So basically your entire argument is wrong.

You're missing that the probability of getting Covid is less than 1. And that bad symptoms from Covid are highly age dependent.

The AZ vaccine has been banned or disused in many countries (it's not even approved in the US!). Do you know something multiple world governments don't?

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