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Oxford University breakthrough on global COVID-19 vaccine

ox.ac.uk

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Re: Oxford University breakthrough on global COVID-19 vaccine

#51

Post by bawolff »

camkego wrote: post #16

This statement seems a big deal: "There were no hospitalised or severe cases in anyone who received the vaccine" Is that also true of the Pfizer and Moderna trials? Are the various trials measuring 'effectiveness' in the same way? Is there a standard for 'effectiveness' in these Covid-19 trials? It will take some digging and real effort to compare the risks and benefits of the various vaccines coming to market.

Seems like the sample size is probably too small to draw any conclusions there. 131 got covid in the trial, if 70% effective than 39 should be from the group that got the vaccine (i think. Did i do that right given they're combining the two dosing regime)?

Maybe its chance that none of those 39 got really sick. I'm not sure what the age breakdown of trial participants was- were the people in the oxford trial younger? Did the distribution match the distribution from the mRNA trials? I have no idea.

Re: Oxford University breakthrough on global COVID-19 vaccine

#52

Post by singingfish »

threeseed wrote: post #27
agd wrote: post #10

I think I read (and I may be wrong) that the costs for the vaccines per dose were roughly as follows: Moderna: £45, Pfizer: £20, Oxford: £3, The Oxford one is also easier to store and transport.

Oxford one is also going to be easier to manufacture given that it is based on existing technology. Many countries e.g. Australia are licensing the formula so this is an important aspect.

the mRNA style viruses will probably decrease in cost exponentially the same way that DNA sequencing and computer technology have dropped in price.

Re: Oxford University breakthrough on global COVID-19 vaccine

#53

Post by photon-torpedo »

ksec wrote: post #31

Incoming possible Silly, Stupid and Lazy Questions, 1. Are there any vaccine ( of any Disease ) that are 100% effective? Or do we operate ( as I would assume ) something like 5 Nines effective rate and call it 100%? 2. Across all type of Vaccine, what are the average or median effective rate? i.e Should we expect Vaccine to be 90%+ effective in the first place? Or is that a wrong expectation to make? 3. What happens…

Not an epidemiologist, but I think the goal of mass vaccination if to make R drop to well below 1. If everybody is vaccinated with a 90% effective vaccine, then R drops by a factor of 10 (I think) so that sounds pretty good?

Re: Oxford University breakthrough on global COVID-19 vaccine

#54

Post by SilentBan »

threeseed wrote: post #32
bawolff wrote: post #20

Earlier quoted context omitted.

Google claims that the smallpox vaccine was somewhere between 90-97% effective (they didnt do fully controlled studies back in the day) Keep in mind, that controlling covid is a giant win. We don't need to eradicate it, just get things under control.

> We don't need to eradicate it, just get things under control Based on what we've seen there is no grey area. Either you fully control it which then ends up basically eradicating it e.g. Australia/NZ or you don't and then you end up like EU/US and going in and out of infection waves.

From what I see you are a braindamaged lockdowncel.

Re: Oxford University breakthrough on global COVID-19 vaccine

#56

Post by austhrow743 »

ksec wrote: post #48
dragontamer wrote: post #36

Earlier quoted context omitted.

> 2. Across all type of Vaccine, what are the average or median effective rate? i.e Should we expect Vaccine to be 90%+ effective in the first place? Or is that a wrong expectation to make? Sometimes, vaccines are only 30% or 40% effective, leading to terrible flu seasons. I don't really know the mean/median/mode, but 90% is really high for a vaccine. > 3. What happens in the case of 10% ineffective, do they take a t…

>How do you know if someone is one of those 10%? I would assume everyone have the vaccine and they still get caught COVID afterwards? Or do I misunderstood what effective means?

If they already got Covid then a third dose of vaccine is pointless.

Re: Oxford University breakthrough on global COVID-19 vaccine

#57

Post by bawolff »

jakozaur wrote: post #41

Title is misleading. They tested few configurations, we should use the most optimal one, not the average. Much better source: https://www.astrazeneca.com/media-centre/press-releases/2020... Good: + likely 90% effective if we use optimal dosing + no significant side effective. Looks better than Pfizer or Moderna. + already pre-produced at huge scale, 3 Bln doses in 2021 + easy to store and administer, just regular fri…

Interesting its cheaper than mRNA, i thought that was one of the benefits of using mRNA, was that it was supposed to be cheaper to manufacture.

Re: Oxford University breakthrough on global COVID-19 vaccine

#58

Post by oblio »

threeseed wrote: post #32
bawolff wrote: post #20

Earlier quoted context omitted.

Google claims that the smallpox vaccine was somewhere between 90-97% effective (they didnt do fully controlled studies back in the day) Keep in mind, that controlling covid is a giant win. We don't need to eradicate it, just get things under control.

> We don't need to eradicate it, just get things under control Based on what we've seen there is no grey area. Either you fully control it which then ends up basically eradicating it e.g. Australia/NZ or you don't and then you end up like EU/US and going in and out of infection waves.

Not really. We haven't (yet?) eradicated the cold or the flu, but we manage to live with them. We need to be able to protect the most vulnerable (probably something like 30% of the population) and reduce load on the healthcare system.

Right now if every activity would be fully available (concerts, conferences, airlines, etc.) every healthcare system across the world would probably be overwhelmed within 2 months, max.

Once we reduce the rates to a trickle, things are probably good enough.

I'm not saying that we shouldn't try to eradicate it, but as with everything, unfortunately, things are frequently taken to a point where they're "good enough" and no further.

Re: Oxford University breakthrough on global COVID-19 vaccine

#59

Post by tzs »

afterburner wrote: post #45
jakozaur wrote: post #41

Title is misleading. They tested few configurations, we should use the most optimal one, not the average. Much better source: https://www.astrazeneca.com/media-centre/press-releases/2020... Good: + likely 90% effective if we use optimal dosing + no significant side effective. Looks better than Pfizer or Moderna. + already pre-produced at huge scale, 3 Bln doses in 2021 + easy to store and administer, just regular fri…

The two existing mRNA vaccines touted earlier also require two doses.

I wonder what happens if you get two doses, but not of the same vaccine?

Re: Oxford University breakthrough on global COVID-19 vaccine

#60

Post by [deleted] »

SpaceRaccoon wrote: post #47
threeseed wrote: post #21

Earlier quoted context omitted.

There were no hospitalisations or severe incidents for either the Pfizer and Moderna trials were was related to the vaccine. And it's pretty easy to compare the vaccines. It will mostly come down to price, ease of manufacture and ease of distribution i.e. temperature. Given that for the 3 viruses all have no risks associated with their use.

How do we know there aren't long term side effects?

[deleted]
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